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Fig. 3 | BMC Oral Health

Fig. 3

From: Low-dose arecoline regulates distinct core signaling pathways in oral submucous fibrosis and oral squamous cell carcinoma

Fig. 3

KEGG and GSEA enrichment analysis of DEGs in NFs and CAL27 cells after low-dose arecoline treatment. A, B For the scatter diagram of KEGG enrichment analysis, KEGG enrichment is measured by gene ratio, p-value, and the number of enriched genes in the pathway. Gene ratio refers to the ratio of the number of DEGs enriched in the pathway to the total number of DEGs. A larger GeneRatio indicates a greater degree of enrichment, and the value range of the p-value is [0,1]. The closer it is to zero, the more significant the enrichment is. C GSEA of key pathways in CAL27 cells by induction of low-dose arecoline. p-value < 0.05 and normalized enrichment score |NES|> 1 were considered statistically significant. NES, normalized enrichment score. FDR, false discovery rate. Positive and negative NES indicate higher and lower expression after low-dose arecoline treatment. GSEA, gene set enrichment analysis

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BMC Oral Health

ISSN: 1472-6831

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