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Fig. 4 | BMC Oral Health

Fig. 4

From: Low-dose arecoline regulates distinct core signaling pathways in oral submucous fibrosis and oral squamous cell carcinoma

Fig. 4

PPI network of DEGs in low-dose arecoline-treated NFs and CAL27 cells. A PPI network of arecoline-treated NFs. B, C The top two most significant modules screened with the Cytoscape plugin MCODE of treated NFs. D PPI network of arecoline-treated CAL27 cells. E, F. The top two most significant modules screened with the Cytoscape plugin MCODE of treated CAL27 cells. The degrees of all nodes were calculated by cytohubba. Color shades were used to indicate degrees. Nodes with a higher degree will have a darker color. C1E, CAL27 cells with low-dose arecoline treatment; C1C, CAL27 cells without low-dose arecoline treatment; NF1E, NFs with low-dose arecoline treatment; NF1C, NFs without low-dose arecoline treatment

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