Table 2 The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) assessment for the outcomes
Quality assessment | No of patients | Effect | Quality | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
No of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Periodontitis | Periodontal healthy | Relative (95% CI) | Absolute | |
Blood UA levels (Better indicated by lower values) | |||||||||||
8 | observational studies | serious1 | serious2 | no serious indirectness | no serious imprecision | none | 725 | 1201 | - | WMD 0.50 mg/dL higher (0.06 to 0.93 higher) | ⊕ΟΟΟ VERY LOW |
Saliva UA levels (Better indicated by lower values) | |||||||||||
9 | observational studies | serious1 | no serious inconsistency | no serious indirectness | no serious imprecision | reporting bias | 233 | 174 | - | SMD -0.95 lower (-1.23 to -0.68 lower) | ⊕ΟΟΟ VERY LOW |