Table 2 Maternal exposure to medication, supplementation and illnesses during the pregestation and 1st trimester period
Variables | NSOFC (%) | Control (%) | P value | |
|---|---|---|---|---|
Maternal exposure to medication, supplementation and illnesses | ||||
Suplementation 3-months pregestation | Yes | 68 (17.6) | 124 (16.6) | 0.651 |
No | 318 (82.4) | 625 (83.4) | ||
Supplementations 1st trimester | Yes | 313 (81.1) | 616 (82.2) | 0.632 |
No | 73 (18.9) | 133 (17.8) | ||
Medications 3-months pregestation | Yes | 90 (23.3) | 113 (15.1) | < 0.001 |
No | 296 (76.7) | 636 (84.9) | ||
Medications 1st trimester | Yes | 41 (10.6) | 72 (9.6) | 0.591 |
No | 345 (89.4) | 677 (90.4) | ||
Illness 3-months pregestation | Yes | 96 (24.9) | 166 (22.2) | 0.304 |
No | 290 (75.1) | 583 (77.8) | ||
Illness 1st trimester | Yes | 95 (24.9) | 163 (21.8) | 0.230 |
No | 286 (75.1) | 586 (78.2) | ||
Parental nicotine exposure | ||||
Mother smoking during pregestation | Yes | 13 (3.4) | 11 (1.5) | 0.072 |
No | 373 (96.6) | 738 (98.5) | ||
Father smoking during pregestation | Yes | 167 (43.3) | 273 (36.4) | 0.026* |
No | 219 (56.7) | 476 (63.6) | ||
Mother smoking during 1st trimester | Yes | 8 (2.1) | 5 (0.7) | 0.039*,b |
No | 378 (97.9) | 744 (99.3) | ||
Father smoking 1st trimester | Yes | 148 (38.3) | 253 (33.8) | 0.128 |
No | 238 (61.7) | 496 (66.2) | ||
Family factor | ||||
Family history of birth defects | Yes | 132 (34.2) | 35 (4.7) | < 0.001* |
No | 254 (65.8) | 714 (95.3) | ||
Consanguinity | Yes | 173 (44.8) | 270 (36.0) | 0.005* |
No | 213 (55.2) | 479 (64.0) | ||