Table 2 The relationship between post concurrent chemoradiotherapy tooth extraction, mandibular dose, post concurrent chemoradiotherapy osteoradionecrosis, concurrent chemotherapy cycles and two hemoglobin-to-platelet ratio groups
Characteristics | All patients (N = 193) | HPR ≤ 0.48 (N = 60) | HPR > 0.48 (N = 133) | P-value |
|---|---|---|---|---|
Median MMPD; Gy (range) | 62.6 (52.7–71.8) | 63.7 (53.8–70.7) | 61.1 (52.7–71.8) | 0.89 |
MMD, Gy (range) | 48.6 (17.4–64.1) | 47.3 (17.4–64.1) | 49.9 (19.2–63.4) | 0.37 |
MMD group, N (%) < 50.6 Gy ≥ 50.6 Gy | 132 (68.4) 61 (31.6) | 42 (70.0) 18 (30.0) | 90 (67.7) 43 (32.3) | 0.78 |
V64 Gy group, N (%) < 27% ≥ 27% | 158 (81.9) 35 (18.1) | 50 (83.3) 10 (16.7) | 108 (81.2) 25 (18.8) | 0.86 |
Continued smoking, N (%) Yes No | 64 (33.2) 129 (66.8) | 21 (35.0) 39 (65.0) | 43 (32.3) 90 (67.7%) | 0.67 |
Continued alcohol consumption, N (%) Yes No | 56 (29.0) 137 (71.0) | 17 (28.3) 43 (71.7) | 39 (29.3) 94 (70.7) | 0.90 |
Median post-C-CRT extracted teeth, N (range) | 1 (0–5) | 2 (0–5) | 1 (0–4) | 0.38 |
Post-C-CRT tooth extraction, N (%) Absent Present | 31 (16.1) 162 (83.9) | 11 (18.3) 49 (81.7) | 20 (15.0) 113 (85.0) | 0.87 |
Median time from C-CRT to tooth extraction, mo. (range) | 7 (1–13) | 6 (1–11) | 8 (1–13) | 0.71 |
Time of post-C-CRT tooth extraction, mo. N (%) > 5.5 ≤ 5.5 | 61 (31.6) 132 (68.4) | 18 (30.0) 42 (70.0) | 43 (32.3) 90 (67.7) | 0.82 |
ORN, N (%) Absent Present | 172 (89.1) 21 (10.9) | 42 (70.0) 18 (30.0) | 130 (97.7) 3 (2.3) | < 0.001 |
ORN stage *0 1 2 | 172 (89.1) 16 (8.3) 5 (2.6) | 42 (70.0) 13 (21.7) 5 (8.3) | 130 (97.7) 3 (2.3) 0 (0.0) | < 0.001 |
Median C-CRT to ORN interval, mo. (range) | 20.8 (12.4–27.6) | 22.4 (12.4–27.6) | 19.1 (11.8–26.4) | 0.49 |
Concurrent chemotherapy cycles, N (%) 1 2–3 | 32 (16.6) 161 (83.4) | 10 (16.7) 50 (83.3) | 22 (16.5) 111 (83.5) | 0.92 |