Pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases: systematic review and meta-analysis

Oliveira, Jovânia Alves; de Oliveira Alves, Roberta; Nascimento, Isabella Mazarelo; Hidalgo, Marco Antonio Rimachi; Scarel-Caminaga, Raquel Mantuaneli; Cristina Pigossi, Suzane

doi:10.1186/s12903-023-03072-1

Table 4 Summarized findings of qualitative analysis (systematic review) for IL-1 versus IL-10, IL-6 versus IL-10, IL-1 versus IL-1Ra, and RANKL versus OPG

From: Pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases: systematic review and meta-analysis

IL-1 versus IL-10
Cytokine	Sample type	Peri-implant mucositis/peri-implantitis versus control	Studies
IL-1β	PICF	Higher in disease	Guncu et al. 2012 [41], Casado et al. 2013 [27], Kandaswamy et al. 2022 [21]
IL-10	PICF	Higher in disease	Guncu, Akman et al. 2012 [41], Kandaswamy et al. 2022 [21]
IL-10	PICF	Lower in disease	Casado et al. 2013 [27]
Cytokine	Sample type	Peri-implant mucositis versus peri-implantitis	Studies
IL-1β	PICF	Higher in peri-implantitis	Casado et al. 2013 [27], Fonseca et al. 2014 [39], Kandaswamy et al. 2022 [21]
IL-1β	PICF	Lower in peri-implantitis	Teixeira et al. 2017 [33]
IL-10	PICF	Lower in peri-implantitis	Casado et al. 2013 [27], Fonseca, Moraes et al. 2014 [39], Teixeira et al. 2017 [33], Kandaswamy et al. 2022 [21]
*IL-1 versus IL-1Ra*
Cytokine	Sample type	Peri-implantitis versus control	Studies
IL-1β	PICF	Higher in disease	Song et al. 2022 [47]
IL-Ra	PICF	Lower in disease	Song et al. 2022 [47]
*IL-6 versus IL-10*
Cytokine	Sample type	Peri-implant mucositis/peri-implantitis versus control	Studies
IL-6	PICF	Higher in disease	Severino et al. 2011 [48], Fonseca et al. 2014 [39], Ata-Ali et al. 2015 [8], Severino et al. 2016 [4], Kandaswamy et al. 2022 [21]
IL-6	Saliva	Higher in disease	Severino et al. 2016 [48]
IL-10	PICF	Higher in disease	Ata-Ali et al. 2015 [8], Severino et al. 2016 [4], Kandaswamy et al. 2022 [21]
IL-10	PICF	Lower in disease	Severino et al. 2011 [48], Fonseca et al. 2014 [39]
IL-10	Saliva	Lower in disease	Severino et al. 2016 [4]
Cytokine	Sample type	Peri-implant mucositis versus peri-implantitis	Studies
IL-10	PICF	Lower in peri-implantitis	Severino et al. 2016 [4], Teixeira et al. 2017 [33], Kandaswamy et al. 2022 [21]
*RANKL versus OPG*
Cytokine	Sample type	Peri-implant mucositis/peri-implantitis versus control	Studies
RANKL	PICF	Higher in disease	Guncu et al. 2012 [41], Rakic et al. 2013 [43], Rakic et al. 2014 [44], Rakic et al. 2015 [45], Yakar et al. 2019 [49], Chaparro et al. 2020 [36], Rakic et al. 2020 [46], Milinkovic et al. 2021 [42], Chaparro et al. 2022 [37]
RANKL	Tissue sample	Higher in disease	Duarte, De Mendonça et al. 2009 [28] Ghighi, Llorens et al. 2018 [53]
OPG	PICF	Higher in disease	Guncu et al. 2012 [41], Rakic et al. 2013 [43], Rakic et al. 2014 [44], Rakic et al. 2015 [45], Yakar et al. 2019 [49], Chaparro et al. 2020 [36], Rakic et al. 2020 [46], Milinkovic et al. 2021 [42], Chaparro et al. 2022 [37]
OPG	Tissue sample	Lower in disease	Duarte et al. 2009 [28], Ghighi et al. 2018 [53]
Cytokine	Sample type	Peri-implant mucositis versus peri-implantitis	Studies
RANKL	PICF	Higher in peri-implantitis	Arıkan et al. 2008 [34], Duarte et al. 2009 [38] Rakic et al. 2014 [44], Milinkovic et al. 2021 [42]
RANKL	PICF	Lower in peri-implantitis	Rakic, Monje et al. 2020 [46]
RANKL	Tissue sample	Higher in peri-implantitis	Duarte et al. 2009 [38]
OPG	PICF	Higher in peri-implantitis	Arıkan et al. 2008 [34], Rakic et al. 2014 [44]
OPG	PICF	Lower in peri-implantitis	Duarte et al. 2009 [38], Chaparro et al. 2020 [36], Rakic et al. 2020 [46], Milinkovic et al. 2021 [42], Chaparro et al. 2022 [37]
OPG	Tissue sample	Higher in peri-implantitis	Duarte et al. 2009 [28]

PICF peri-implant crevicular fluid

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