Pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases: systematic review and meta-analysis

Oliveira, Jovânia Alves; de Oliveira Alves, Roberta; Nascimento, Isabella Mazarelo; Hidalgo, Marco Antonio Rimachi; Scarel-Caminaga, Raquel Mantuaneli; Cristina Pigossi, Suzane

doi:10.1186/s12903-023-03072-1

Table 5 RANKL: OPG and OPG: RANKL ratio in peri-implant crevicular fluid and tissue samples from mucositis, peri-implantitis, and health patients

From: Pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases: systematic review and meta-analysis

RANKL: OPG
Control versus Mucositis Peri-implant crevicular fluid
Author, Year	Evaluation Method	Control	Disease
Chaparro, Sanz et al. (2020) [36]	MULTIPLEX	0.29 (0.26 – 0.43)	0.37 (0.24 – 0.58)
Guncu, Akman et al. (2012) [41]	ELISA	2,65 ± 1,64	1,71 ± 0,89
Rakic, Struillou et al. (2014) [44]	ELISA	0,72 ± 0,63	0,92 ± 1,32
Rakic, Monje et al. (2020) [46]	ELISA		HIDS***
Control versus Peri-implantitis Peri-implant crevicular fluid
Author, Year	Evaluation Method	Control	Disease
Arikan, Buduneli et al. (2011) [35]	ELISA	0,4 ± 0,2	0,8 ± 0,9
Chaparro, Sanz et al. (2020) [36]	MULTIPLEX	0.29 (0.26 – 0.43)	0.31 (0.21 – 0.56)
Ghighi, Llorens et al. (2018) [40]	MULTIPLEX		HIDS**
Rakic, Lekovic et al. (2013) [43]	ELISA	0,81 ± 0,61	1,01 ± 1,17
Rakic, Struillou et al. (2014) [44]	ELISA	0,72 ± 0,63	1,01 ± 1,23
Rakic, Petkovic-Curcin et al. (2015) [45]	ELISA	0,40 ± 0,33	1,51 ± 1,14
Rakic, Monje et al. (2020) [46]	ELISA		HIDS***
Yakar, Guncu et al. (2019) [49]	ELISA	0,0153 ± 0,0171	0,0234 ± 0,0244
Mucositis versus Peri-implantitis Peri-implant crevicular fluid
Author, Year	Evaluation Method	Mucositis	Peri-implantitis
Chaparro, Sanz et al. (2020) [36]	MULTIPLEX	0.37 (0.24 – 0.58)	0.31 (0.21 – 0.56)
Rakic, Struillou et al. (2014) [44]	ELISA	0,92 ± 1,32	1,01 ± 1,23
Rakic, Monje et al. (2020) [46]	ELISA		HIPS^**
OPG: RANKL
Control versus Mucositis Peri-implant crevicular fluid
Author Year	Evaluation Method	Control	Disease
Duarte, de Mendonça et al. (2009) [38]	ELISA	2,79 ± 2,08	1,56 ± 0,96
Control versus Peri-implantitis Peri-implant crevicular fluid
Author Year	Evaluation Method	Control	Disease
Duarte, de Mendonça et al. (2009) [38]	ELISA	2,79 ± 2,08	1,04 ± 0,76
Tissue sample
Author Year	Evaluation Method	Control	Disease
Duarte, De Mendonça et al. (2009) [28]	PCR	20 ± 11,6	1,2 ± 0,7
Mucositis versus Peri-implantitis Peri-implant crevicular fluid
Author Year	Evaluation Method	Mucositis	Peri-implantitis
Duarte, de Mendonça et al. (2009) [38]	ELISA	1,56 ± 0,96	1,04 ± 0,76

HIDS Higher in Diseased Subjects, HIPS Higher in Peri-implantitis Subjects
^**p < 0.01
^***p˂0.00,1

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