Table 1 Literature search conducted to identify studies. (Last search date March 29^th, 2023)

MEDLINE (via PubMed)

#1

"shear strength"[MeSH Terms] OR "shear strength"[Title/Abstract] OR "bond strength"[Title/Abstract] OR "shear bond strength"[Title/Abstract]

21,679

#2

caseins[MeSH Terms] OR "casein phosphopeptide amorphous calcium phosphate nanocomplex"[Supplementary Concept] OR "casein phosphopeptide amorphous calcium phosphate"[Title/Abstract] OR "cpp acp"[Title/Abstract]

17,173

#3

"orthodontic brackets"[MeSH Terms] OR "orthodontic bracket*"[Title/Abstract] OR "orthodontic brace*"[Title/Abstract] OR "metal bracket*"[Title/Abstract] OR "metal brace*"[Title/Abstract] OR "metallic bracket*"[Title/Abstract]

5,521

#4

#1 AND #2 AND #3

24

Scopus

#1

TITLE-ABS-KEY (“shear strength” OR “shear bond strength” OR “bond strength”)

130,011

#2

TITLE-ABS-KEY (“casein phosphopeptide-amorphous calcium phosphate” OR “CPP-ACP”)

820

#3

TITLE-ABS-KEY ("orthodontic brackets" OR “orthodontic braces” OR “metal* bracket*” OR “metal* brace*”)

6,117

#4

#1 AND #2 AND #3

22

Cochrane

#1

[mh "Shear Strength"] OR “shear strength”:ti,ab,kw OR “bond strength”:ti,ab,kw OR “shear bond strength”:ti,ab,kw

1,149

#2

[mh "caseins"] OR “casein phosphopeptide-amorphous calcium phosphate”:ti,ab,kw OR “CPP-ACP”:ti,ab,kw

623

#3

[mh "Orthodontic Brackets"] OR orthodontic NEXT bracket*:ti,ab,kw OR orthodontic NEXT brace*:ti,ab,kw OR metal* NEXT bracket*:ti,ab,kw OR metal* NEXT brace*:ti,ab,kw

981

#4

#1 AND #2 AND #3

1

Web Of Science

#1

(((((TI=("shear strength")) OR TI=("shear bond strength")) OR AB=("shear strength")) OR AB=("shear bond strength")) OR AK=("shear strength")) OR AK=("shear bond strength")

47,946

#2

(((((TI=("casein phosphopeptide-amorphous calcium phosphate")) OR TI=("CPP-ACP")) OR AB=("casein phosphopeptide-amorphous calcium phosphate ")) OR AB=("CPP-ACP")) OR AK=("casein phosphopeptide-amorphous calcium phosphate")) OR AK=("CPP-ACP")

549

#3

(((((((((((TI=("orthodontic bracket*")) OR TI=("orthodontic brace*")) OR AB=(" orthodontic bracket*")) OR AB=("orthodontic brace*")) OR AK=(" orthodontic bracket*”)) OR AK=("orthodontic brace*")) OR TI=("metal* bracket*")) OR TI=("metal* brace*")) OR AB=("metal* bracket*")) OR AB=("metal* brace*")) OR AK=("metal* bracket*")) OR AK=("metal* brace*")

2,433

#4

#1 AND #2 AND #3

22

Google scholar

https://scholar.google.com.eg/

allintitle: ("shear strength" OR "shear bond strength") AND ("casein phosphopeptide-amorphous calcium phosphate" OR "CPP-ACP") AND ("orthodontic bracket" OR "metal bracket" OR "orthodontic brackets" OR "metal brackets")

7