Fig. 2From: Dental arch spatial changes after premature loss of first primary molars: a systematic review and meta-analysis of split-mouth studiesForest plot of space differences (D/D + E) between the extraction and control sides (A) D + E space differences in the maxilla. (B) D space differences in the mandible. (C) D + E space differences in the mandible. Space was significantly reduced compared with the control side (P < 0.05 each)Back to article page