Table 2 Clinical characteristics of the included literature
Study | Periodontitis diagnostic criteria | Periodontitis severity | Interventions Control Treatment | Influence/confounding factor | Follow-up time | Outcome | ||
|---|---|---|---|---|---|---|---|---|
Olszewska-Czyz, I 2022 [17] | 2017 Classification of Periodontal Disease | I to IV | NM | Age, Sex, BMI | NM | Vitamin D3 and Clinical Parameters | ||
Costantini, E 2020 [22] | 2017 World Workshop on the basis of clinical data | II to IV | NA | NM | NM | PD, CAL, 25(OH)D | ||
Abreu, O 2016 [30] | PD and AL at 6 sites on all teeth | Moderate to severe | NA NM | Socio-economic status and Physical activity | NM | 25 (OH)D, PD, AL | ||
Alzahrani, A 2021 [31] | HANES/AAP/CDC | Severe or moderate | NM | Age, Gender, and BMI | NM | 25(OH)D, Odds of periodontitis | ||
Anbarcioglu, E 2019 [32] | PPD > 4 mm, AL of > 3 mm | NM | NM | PTH and ALP | NM | PD, CAL, BOP, PI, GI, 1,25(OH)2D | ||
Gao, W 2020 [33] | At least six sites with PD ≥ 6 mm, AL ≥ 4 mm | Moderate to severe | SRP | SRP + 2000 IU/d VD SRP + 1000 IU/d VD | NM | 3 months | PD,CAL,BI,25(OH)D | |
Ketharanathan, V 2019 [34] | CAL ≥ 6 mm in 2 or more teeth and one or more sites PPD ≥ 5 mm | NM | NM | Smoking, Age | NM | Vitamin D | ||
Laky, M 2017 [35] | A minimum of five teeth with a PPD ≥ 5 mm | NM | NM | NM | NM | 25(OH)D, Vitamin D,PPD, CAL | ||
Liu, K 2010 [36] | 1999 Classification of Periodontal Diseases | NM | Before SRP | After SRP | NM | 6Â months | 25(OH)D3, PD, AL, BI | |
Miley, D 2009 [37] | At least two interproximal sites with 3Â mm CAL | Moderate to severe | NM | Race,Smoking, Gender, and Sun exposure | NM | PD, AL, GI | ||
Miricescu, D 2014 [38] | Six sites PD ≥ 4 mm; bone loss higher than 30% | NM | NA | Smoke, Age | NM | PD,PI,GI,25(OH)D | ||
Pai, S 2021 [39] | Involvement of (> 30% sites) CAL (3–4 mm) | Moderate to severe | Before SRP | After SRP | NM | 3 months | GI, PI, CAL, PD, Vitamin D | |
Perayil, J 2015 [40] | One or more with chronic periodontitis, AL of 3-4 mm | Moderate | SRP | SRP + VD | NM | 3 months | Vitamin D, GI, PPD, CAL | |
Perić, M 2020 [41] | AAP | NM | SRP | SRP + VD | Age,Gender,Smoking | 6 months | Vitamin D, PPD | |
Pradhan, S 2021 [42] | 1999 classification of periodontal disease | NM | NM | NM | NM | Vitamin D | ||
Rafique, S 2019 [43] | CAL ≥ 1 mm at two or more nonadjacent sites | Mild to severe | NM | Age and Gender | NM | GI, PI, CAL, PPD,25(OH)D | ||