Fig. 2

Result of single-cell analysis and its use in determining the key targets of Curcumin in the treatment of periodontitis. A Clusters of specific cell types in healthy individuals and periodontitis samples. B Bar chart demonstrating the distribution of each cell type appeared in individuals and periodontitis samples. Distinct differences between the two are observed. C) Venn diagram that showcases the intersection of the DEGs curated from bulk RNAseq and the marker genes in the single-cell analysis as well as the verified targets of the curcumin molecule. D An interactive network exhibiting the enriched GO terms and KEGG pathways that are statistically significant. Nodes in blue color represented the genes, while those in red color represented the enriched GO terms and KEGG pathways