Fig. 3

FOS, CXCL1, CXCL8, and IL1B were filtered out as candidate targets in inflammatory immunity and bacterial resistance in the treatment of periodontitis with curcumin. A Primary PPI network of the overlapping genes selected from the last step. Nodes in black color represented the protein-encoding genes we input into the GeneMANIA system, while those in grey color represented the protein-encoding genes derived from the input by the system. Nodes in the yellow color were categorized into the same cluster with a score of 10.2 by the MCODE algorithm. Similarly, nodes in the blue color were also categorized into a cluster with a score of 3. B The first MCODE-defined cluster mentioned in the text. C The second MCODE-defined cluster mentioned in the text. D Functional enrichment analysis of the GO terms and KEGG pathways for the members in the first cluster