Table 2 Characteristics of the included studies
Author and year | Type | Cell type | Case number(TEST/CTRL) | Age | Clinical intervention | Follow-up period | Primary outcome | |
|---|---|---|---|---|---|---|---|---|
Test | Control | |||||||
Apatzidou 2021 | RCT | Autologous alveolar bone marrow mesenchymal stem cells (aABMMSCs) | 19 patients(9/10) | 20–68 | A biocomplex comprising aABMMSCs, prepared under clinical-grade, current Good Manufacturing Practice(cGMP) conditions suspended into autologous fibrin/platelet lysate (aFPL), and loaded into a collagen fleece was transplanted into the osseous defect. | Collagen fleece enriched with aFPL devoid of stem cells filled the osseous defect or the defects were treated by the Minimal Access Flap | 12 months | CAL; PPD; REC; CEJ-BD; BC-BD; WD. |
Sánchez 2020 | RCT | Autologous periodontal ligament-derived mesenchymal stem cells (aPDLSCs) | 20 patients(9/10)a | 25–70 | The experimental treatment consisted of 1 × 107 aPDLSCs incubated for 1 h (37ºC, 5% CO2 and 95% humidity) in 100 mg of a xenogeneic bone substitute. | The control treatment comprised the use of the same xenogeneic bone substitute seeded in 200 μm of physiological saline solution. | 12 months | FMPI; CAL; PPD; REC. |
Abdal-Wahab 2020 | RCT | Autologous gingival fibroblasts and their associated mesenchymal stem cells (aGF-GSCs) | 20 patients(10/10) | 32–50 | Ten intrabony periodontal defects received their cultured aGF-GSCs on a beta-tricalcium phosphate scaffold (β- TCP) followed non-perforated collagen membrane coverage | Ten intrabony periodontal defects received β-TCP followed by non-perforated collagen membrane. | 6 months | CAL; VPD(PPD); RBG. |
Ferrarotti 2018 | RCT | Autologous dental pulp stem cells (aDPSCs) | 29 patient(15/14) | 39–69 | The obtained micro-grafts enriched in aDPSCs were endorsed onto a collagen sponge scaffold. The collagen sponge was provided to the masked surgeon who filled the intrabony defect. The flaps were repositioned and tension-free primary flap closure was obtained using horizontal internal mattress and interrupted sutures | The collagen sponge was provided to the masked surgeon who filled the intrabony defect. The flaps were repositioned and tension-free primary flap closure was obtained using horizontal internal mattress and interrupted sutures | 12 months | FMPS; FMBS; PPD; CAL; REC; IBD(BC-BD). |
Chen 2016 | RCT | Autologous periodontal ligament-derived mesenchymal stem cells (aABMMSCs) | 30patients, 41 teeth (20/21) | 18–65 | A standard initial preparation, including oral hygiene instruction, full-mouth scaling, and root planning before surgical treatment. Bio-oss®/cell sheets were administered only to the bony defect region | A standard initial preparation, including oral hygiene instruction, full-mouth scaling, and root planning before surgical treatment. Bio-oss® only were administered only to the bony defect region. | 12 months | BDP(CEJ-BD); CAL; PD; GR(REC). |