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Fig. 4 | BMC Oral Health

Fig. 4

From: Physical, mechanical, and biological properties of collagen membranes for guided bone regeneration: a comparative in vitro study

Fig. 4

Effects of collagen membranes degradation products on the proliferation and differentiation of MC3T3-E1 cells. CCK-8 proliferation assay performed with and without collagen membranes degradation products after 1, 3, and 5 days. b Alkaline phosphatase (ALP) activity of MC3T3-E1 cells incubated with or without collagen membranes degradation products for 1, 7, and 14 days. ALP activity was normalized by total cellular protein amounts. qPCR analysis of osteoblastic marker (c) runt-related transcription factor 2 (Runx2), (d) osteocalcin (OC), and (e) collagen type I (Col-1) relative expression in MC3T3-E1 cells incubated with or without collagen membranes degradation products for 7 and 14 days. The error bars represent ± SD. Two-way analysis of variance analysis. ns: not significant, *P < 0.05, **P < 0.01, ***P < 0.05, ****P < 0.0001. n = 3 for all samples

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BMC Oral Health

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