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Table 4 Logistic regression analysis for severe COVID-19

From: Association between the severity of periodontitis, COVID-19, C-reactive protein and interleukin-6 levels in hospitalized patients: a case‒control study

Outcome

Parameter

Group

Crude Analysis

Adjusted Combined Analysisa

P Value

Odds Ratio (95% CIb)

P Value

Odds Ratio (95% CI)

Severe to Critical COVID-19

Periodontitis Severity

HPc

-

1.0

-

1.0

MP

0.544

1.350 (0.513 – 3.556)

0.528

1.551 (0.397 – 6.052)

SP

 < 0.001*

7.855 (2.896 – 21.305)

0.047*

4.247 (1.020 – 17.683)

Serum IL-6

-

0.002*

1.049 (1.017 – 1.082)

0.033*

1.075 (1.006 – 1.148)

Saliva IL-6

-

0.009*

1.147 (1.035 – 1.272)

-

-

Serum CRP

-

0.097

1.014 (0.998 – 1.030)

0.495

0.991 (0.966 – 1.017)

Saliva CRP

-

0.333

1.084 (0.920 – 1.277)

-

-

Mean CAL

-

 < 0.001*

1.857 (1.424 – 2.423)

-

-

Mean GI

-

0.003*

1.907 (1.242 – 2.926)

-

-

Mean MSBI

-

0.003*

2.059 (1.277 – 3.322)

-

-

Remaining Teeth

-

 < 0.001*

0.807 (0.728 – 0.894)

-

-

Age

-

0.006*

1.042 (1.012 – 1.073)

0.109

1.042 (0.991 – 1.095)

Sex

Femalec

-

1.0

-

1.0

Male

0.694

1.154 (0.565 – 2.354)

0.466

0.646 (0.2 – 2.088)

Comorbidity

Noc

-

1.0

-

1.0

Yes

0.045*

2.211 (1.016 – 4.809)

0.370

1.732 (0.521 – 5.755)

  1. *Statistically significant
  2. aVariables in the combined model: COVID-19, Periodontitis, Serum IL-6, Serum CRP, Age, Sex, Comorbidity
  3. bConfidence Interval
  4. cReference Group