Table 1 The similarities and differences of dentine disorders that form a differential diagnosis to molar-root incisor malformation
From: Molar-root incisor malformation — a systematic review of case reports and case series
Differential Diagnosis | Similarities to MRIM | Differences to MRIM |
|---|---|---|
Dentine dysplasia type 1 OMIM #125,400 | Clinically normal crown Missing or altered, thin, short root formation† Pulp chamber stenosis Both primary and permanent dentitions affected | Autosomal recessive inheritance Expressed in the entire dentition |
Dentine dysplasia type II OMIM #125,420 | Thistle-tube deformity of pulp chambers and root canals Pulp stones Normal root length† | Clinical crown opalescent or translucent Autosomal dominant inheritance Unaffected permanent dentition |
Dentinogenesis imperfecta type I (OMIM #125,490) | Cervical constriction with short or tapered roots Pulp chamber stenosis or obliteration[36] | Clinical crown opalescent or translucent Autosomal dominant inheritance Concurrent diagnosis of osteogenesis imperfecta |
Dentinogenesis imperfecta type II (OMIM #125,490) | Cervical constriction with short or tapered roots Pulp chamber stenosis or obliteration[36] | Clinical crown opalescent or translucent Autosomal dominant inheritance |
Dentinogenesis imperfecta type III (OMIM #125,500) | Primary teeth experience spontaneous pulp exposures[36] | Crowns wear rapidly Permanent teeth have large pulp chambers Amber coloured dentine A “shell” radiographic appearance due to hypotrophy of dentine Autosomal dominant inheritance |
Hypophosphatemic rickets (OMIM #307,800) | Clinically normal crown Short and blunted roots[37]† | Enlarged pulp chambers with extension of pulp to the dentinoenamel junction and hypomineralised dentine X-linked dominant inheritance |
Schimke immunoosseous dysplasia (OMIM #242,900) | Cervical constriction with short or tapered roots Obliteration or stenosis of the pulp chambers Can affect primary and/or permanent dentition[38] | Systemic conditions of spondyloepiphyseal dysplasia, renal dysfunction, T-cell immunodeficiency, and facial dysmorphism Autosomal recessive inheritance |
Regional odontodysplasia | Can affect primary and/or permanent dentition Reduced thickness of dentine and irregular globular dentine Clefts between dentine tubules[35] | Typically localised to one quadrant Tooth crowns are significantly affected |
Segmental odontomaxillary dysplasia | Short roots† Dentine defects in coronal dentine[39] | Atypical form of fibrous dysplasia Agenesis of other teeth Enamel Defects Bone and soft tissue changes |
Hypoparathyroidism and pseudohypoparathyroidism (OMIM #103,580) | Blunting of the root apices† Pulp calcifications[40] | Systemic problems of end-organ resistance to parathyroid hormone Generally found to affect premolars |