Table 1 Subgroup analysis outcomes of CR in PDT treatment for leukoplakia

Light source

LED

7

98%

< 0.001

0.44 (0.16,0.71)

Laser

7

87.7%

< 0.001

0.63 (0.47,0.79)

Other

2

48.8%

0.162

0.17 (-0.12,0.46)

Medium

10% ALA

3

45.4%

0.160

0.78 (0.62,0.94)

20% ALA

8

96.7%

< 0.001

0.47 (0.22,0.71)

Other

6

96.6%

< 0.001

0.44 (0.18,0.70)

Wavelength

≤ 640 nm

13

95.8%

< 0.001

0.46 (0.28,0.64)

＞640 nm

3

96.7%

< 0.001

0.66 (0.36,0.95)

Duration of application

≤ 2 h

11

96%

< 0.001

0.41 (0.22,0.61)

> 2 h

5

62.7%

0.03

0.76 (0.67,0.85)

Pathologic diagnosis

No

dysplasia

4

89.6%

< 0.001

0.51 (0.28,0.73)

Mild dysplasia

6

0%

0.986

0.12 (0.08,0.16)

Moderate dysplasia

3

0%

0.984

0.18 (0.13,0.24)

Severe dysplasia

2

88.6%

0.003

0.22 (-0.03,0.48)

Clinical classification

Homogeneous

2

0%

0.364

0.44 (0.29,0.59)

Non-homogeneous

2

0%

0.877

0.07 (-0.01,0.15)