Table 2 Subgroup analysis outcomes of PR in PDT treatment for leukoplakia

Light source

LED

6

87.7%

< 0.001

0.43 (0.26,0.59)

Laser

7

97.1%

< 0.001

0.38 (0.12,0.65)

Other

2

0%

0.593

0.50 (0.27,0.73)

Medium

10% ALA

2

61.3%

0.108

0.16 (-0.17,0.48)

20% ALA

8

94.7%

< 0.001

0.44 (0.23,0.65)

Other

5

88.8%

< 0.001

0.45 (0.23,0.68)

Wavelength

≤ 640 nm

13

94.7%

< 0.001

0.43 (0.26,0.60)

＞640 nm

2

93.7%

< 0.001

0.32 (-0.02,0.66)

Duration of application

≤ 2 h

10

85.3%

< 0.001

0.53 (0.38,0.67)

> 2 h

5

63.6%

0.027

0.15 (0.08,0.23)

Pathologic diagnosis

No

dysplasia

4

0%

0.432

0.08 (0.04,0.13)

Mild dysplasia

2

21.2%

0.260

0.15 (0.04,0.26)

Moderate dysplasia

2

0%

0.573

0.04 (-0.02,0.10)

Clinical classification

Homogeneous

2

12.4%

0.285

0.13 (0.03,0.23)

Non-homogeneous

2

21.2%

0.260

0.15 (0.04,0.26)