Table 1 Characteristics of the 8 studies included in this meta-analysis
Sample Size | Intervention | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Author (year) | Study design | Country | Experiment group | Control group | Age range (mean) | Female/Male | Type of OLP | Experiment group | Control group | Evaluation methods | Follow-up period | Outcome | Adverse effect |
ElGhareeb 2023 [19] | clinical trail | Egypt | 12 | 12 | 49.55±11.67 | 14/10 | Erosive or Reticular or Mixed | Intralesional PRP every two weeks | Intralesional TA every two weeks | VAS，REU，complete response rate | 3m | Intralesional administration of PRP presents itself as a viable and secure modality for the treatment of OLP in patients. | There were no statistically significant differences between the studied groups in therapeutic response |
Hijazi 2022 [20] | RCT | Egypt | 10 | 10 | 46.45±10.37 | 18/2 | erosive | Intralesional PRP every two weeks | Intralesional TA every two weeks | VAS，Sign score | 3m | PRP injections could be considered as an effective alternative single treatment modality for EOLP. | - |
Al‐Hallak 2021 [15] | RCT | Syria | 12 | 12 | 48±12.7 | 9/3 | Erosive or Reticular or Mixed | Intralesional i-PRF every two weeks | Intralesional TA every two weeks | VAS，REU，Percentage of OLP recurrence | 3m | Intralesional injection with TA showed more effectiveness than i-PRF in the management of OPL lesions. | - |
Saglam 2021 [14] | RCT | Turkey | 24 | 24 | 24-76 | 14/10 | erosive | Intralesional i-PRF every 15-day | Intralesional methylprednisolone acetate every 15-day | VAS，lesion size，OHIP-14 | 6m | In patients with EOLP, both methods decreased pain and lesion size similarly, and both increased satisfaction. | no systemic side effects |
Bennardo 2021 [21] | RCT | Italy | 9 | 9 | 59.56±3.57 | 6/3 | Erosive or Reticular or Mixed | Intralesional i-PRF every week | Intralesional TA every week | VAS，lesion size | 2m | i-PRF seems to be as effective as TA | no side effects were observed |
LH Zheng 2021 [22] | RCT | China | 19 | 19 | 32-81 | 25/13 | Erosive or Reticular or Mixed | Intralesional i-PRF every week | Intralesional TA every week | VAS，Sign score, lesion size， effective rate, recurrence rate | 3m | i-PRF seems to be as effective as TA. | the incidence of adverse reactions in i-PRF group is lower than that of TA group |
Ahuja 2020 [23] | RCT | India | 10 | 10 | 28-60 | 18/2 | erosive | Intralesional PRP every week | Intralesional TA every week | VAS, erythema scores, Mean Lesion size | 4m | Comparison of the pain reduction, size of lesion and erythema scores between the two groups, the difference was found to be statistically insignificant | no side effects were observed. |
Tunalı 2018 [24] | RCT | Turkey | 13 | 13 | - | - | Erosive or Reticular or Mixed | Intralesional i-PRF | Intralesional corticosteroids | VAS, OHQoL, Sign | - | I-PRF injection may be effective in the symptomatic treatment of OLP | - |