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Table 2 Principal elements of the studies which formed part of the present systematic analysis;

From: The effectiveness of chitosan as a hemostatic in dentistry in patients with antiplatelet/anticoagulant therapy: systematic review with meta-analysis

Author

Year

Nationality

Type of study

Number of teeth extracted

Complications with bruxism and no bruxism

Clinical significance

Pippi

2013

Italy

Split mouth randomized controlled trial

20 with HDD

20 control

Time Hemostasis:

Control:7.58 min

Study: 4.7 min

Chitosan has statistically significant effect on bleeding

Schmitter

2023

Germany

Split mouth randomized controlled trial

74 HDD

52 control

Time Hemostasis:

Control: 9.53 min

Study: 0.50 min

Chitosan has statistically significant effect on bleeding

Kumar

2016

India

Split mouth randomized controlled trial

33 HDD

33 control

Time Hemostasis:

Control: 4.06 min

Study: 1.49 min

Chitosan has statistically significant effect on bleeding

Sharma

2017

India

Split mouth randomized controlled trial

40 HDD

40 Control

Time Hemostasis:

Control: 14.1 min

Study: 1.13 min

Chitosan has statistically significant effect on bleeding

Kale

2012

Saudi Arabia

Split mouth randomized controlled trial

40 HDD

40 Control

Time Hemostasis:

Control: 153 s min

Study: 918 s

Chitosan has statistically significant effect on bleeding

Radhakrishna

2022

India

Split mouth randomized controlled trial

54 HDD

54 Control

Time Hemostasis:

Control: 796 s

Study: 96 s

Chitosan has statistically significant effect on bleeding

Sarkar

2022

India

Split mouth randomized controlled trial

30 HDD

30 Control

Time Hemostasis:

Control: 158 s

Study: 70 s

Chitosan has statistically significant effect on bleeding