Table 4 Sensitivity analysis of the causal association between PD and the risk of Lipid metabolism traits
Exposure | Outcome | Cochrane Q test | MR-Egger | MR-PRESSO P value | ||
|---|---|---|---|---|---|---|
Q value | P | Intercept | P | |||
HDL | PD(GLIDE) | 70.33 | 0.85 | -0.001 | 0.77 | 0.88 |
LDL | PD(GLIDE) | 67.97 | 0.54 | -0.002 | 0.53 | 0.62 |
TC | PD(GLIDE) | 53.55 | 0.98 | 0.002 | 0.61 | 0.99 |
TG | PD(GLIDE) | 50.90 | 0.63 | -0.007 | 0.11 | 0.69 |
HDL | CP(FinnGen) | 60.67 | 0.96 | 0.007 | 0.22 | 0.97 |
LDL | CP(FinnGen) | 64.65 | 0.62 | -0.002 | 0.69 | 0.67 |
TC | CP(FinnGen) | 73.09 | 0.69 | 0.002 | 0.005 | 0.74 |
TG | CP(FinnGen) | 56.40 | 0.34 | -0.003 | 0.60 | 0.33 |
HDL | PD(GCST90018897) | 87.72 | 0.36 | -0.007 | 0.07 | 0.40 |
LDL | PD(GCST90018897) | 75.47 | 0.30 | 0.004 | 0.22 | 0.14 |
TC | PD(GCST90018897) | 104.47 | 0.06 | -0.001 | 0.88 | 0.06 |
TG | PD(GCST90018897) | 56.03 | 0.43 | 0.002 | 0.60 | 0.44 |
PD(GLIDE) | HDL | NA | NA | NA | NA | NA |
PD(GLIDE) | LDL | NA | NA | NA | NA | NA |
PD(GLIDE) | TC | NA | NA | NA | NA | NA |
PD(GLIDE) | TG | NA | NA | NA | NA | NA |
CP(FinnGen) | HDL | NA | NA | NA | NA | NA |
CP(FinnGen) | LDL | NA | NA | NA | NA | NA |
CP(FinnGen) | TC | NA | NA | NA | NA | NA |
CP(FinnGen) | TG | NA | NA | NA | NA | NA |
PD(GCST90018897) | HDL | 0.07 | 0.96 | -0.001 | 0.90 | 0.98 |
PD(GCST90018897) | LDL | 0.22 | 0.89 | -0.001 | 0.92 | 0.97 |
PD(GCST90018897) | TC | 0.59 | 0.74 | 0.006 | 0.58 | 0.69 |
PD(GCST90018897) | TG | 5.88 | 0.05 | 0.016 | 0.25 | 0.12 |