Table 1 Baseline characteristics of patients with cN0 OSCC
Disease-Specific Survival | Overall Survival | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
END | No END | END | No END | |||||||||||||
parameters | Alive | Dead | Total | P-value | Alive | Dead | Total | P-value | Alive | Dead | Total | P-value | Alive | Dead | Total | P-value |
Sex | 0.669c | 0.669 | ||||||||||||||
0.930a | 0.096 | 0.123 | 0.488 | |||||||||||||
Female | 1524 | 190 | 1714(42b) | 4454 | 1403 | 5857(45.3) | 1434 | 280 | 1714(42) | 3685 | 2172 | 5857(45.3) | ||||
Male | 2104 | 260 | 2364(58) | 5475 | 1609 | 7084(54.7) | 1934 | 430 | 2364(58) | 4415 | 2669 | 7084(54.7) | ||||
Age (y) | 0.279 | 0.279 | ||||||||||||||
< 0.001 | < 0.001 | < 0.001 | < 0.001 | |||||||||||||
≤ 50 | 522 | 47 | 569(14) | 1061 | 166 | 1227(9.5) | 510 | 59 | 569(14) | 1004 | 223 | 1227(9.5) | ||||
50–59 | 846 | 92 | 938(23) | 1997 | 409 | 2406(18.6) | 797 | 141 | 938(23) | 1827 | 579 | 2406(18.6) | ||||
60–69 | 1109 | 122 | 1231(30.2) | 2711 | 618 | 3329(25.7) | 1036 | 195 | 1231(30.2) | 2361 | 968 | 3329(25.7) | ||||
70–79 | 798 | 91 | 889(21.8) | 2359 | 746 | 3105(24) | 737 | 152 | 889(21.8) | 1862 | 1243 | 3105(24) | ||||
≥ 80 | 353 | 98 | 451(11.1) | 1801 | 1073 | 2874(22.2) | 288 | 163 | 451(11.1) | 1046 | 1828 | 2874(22.2) | ||||
Race | 0.918 | 0.918 | ||||||||||||||
0.015 | < 0.001 | < 0.001 | < 0.001 | |||||||||||||
White | 2959 | 390 | 3349(82.1) | 8616 | 2575 | 11,191(86.5) | 2734 | 615 | 3349(82.1) | 6988 | 4203 | 11,191(86.5) | ||||
Black | 161 | 22 | 183(4.5) | 379 | 200 | 579(4.5) | 152 | 31 | 183(4.5) | 281 | 298 | 579(4.5) | ||||
AI | 23 | 2 | 25(0.6) | 48 | 15 | 63(0.5) | 18 | 7 | 25(0.6) | 38 | 25 | 63(0.5) | ||||
API | 455 | 36 | 491(12) | 786 | 219 | 1005(7.8) | 434 | 57 | 491(12) | 696 | 309 | 1005(7.8) | ||||
Other | 30 | 0 | 30(0.7) | 100 | 3 | 103(0.8) | 30 | 0 | 30(0.7) | 97 | 6 | 103(0.8) | ||||
Marital status | 0.807 | 0.807 | ||||||||||||||
0.025 | < 0.001 | < 0.001 | < 0.001 | |||||||||||||
Single | 628 | 73 | 701(14.5) | 1376 | 453 | 1829(17.1) | 576 | 125 | 701(17.2) | 1135 | 694 | 1829(14.1) | ||||
Married | 2019 | 228 | 2247(53.1) | 5483 | 1329 | 6812(55.3) | 1908 | 339 | 2247(55.1) | 4680 | 2132 | 6812(52.6) | ||||
Other | 981 | 149 | 1130(32.4) | 3070 | 1230 | 4300(27.6) | 884 | 246 | 1130(27.7) | 2285 | 2015 | 4300(33.2) | ||||
T | 0.003 | 0.003 | ||||||||||||||
< 0.001 | < 0.001 | < 0.001 | < 0.001 | |||||||||||||
T1 | 1416 | 118 | 1534(37.6) | 7128 | 1157 | 8285(64) | 1333 | 201 | 1534(37.6) | 6112 | 2173 | 8285(64) | ||||
T2 | 1172 | 131 | 1303(32) | 1885 | 886 | 2771(21.4) | 1093 | 210 | 1303(32) | 1399 | 1372 | 2771(21.4) | ||||
T3 | 332 | 53 | 385(9.4) | 319 | 290 | 609(4.7) | 303 | 82 | 385(9.4) | 197 | 412 | 609(4.7) | ||||
T4 | 708 | 148 | 856(21) | 597 | 679 | 1276(9.9) | 639 | 217 | 856(21) | 392 | 884 | 1276(9.9) | ||||
M | 0.605 | 0.605 | ||||||||||||||
0.003 | < 0.001 | < 0.001 | < 0.001 | |||||||||||||
M0 | 3619 | 445 | 4064(99.7) | 9879 | 2929 | 12,808(99) | 3362 | 702 | 4064 | 8076 | 4732 | 12,808 | ||||
M1 | 7 | 5 | 12(0.3) | 30 | 75 | 105(0.8) | 5 | 7 | 12 | 12 | 93 | 105 | ||||
MX | 2 | 0 | 2(0) | 20 | 8 | 28(0.2) | 1 | 1 | 2 | 12 | 16 | 28 | ||||
Primary sites | 0.910 | 0.910 | ||||||||||||||
0.007 | < 0.001 | < 0.001 | < 0.001 | |||||||||||||
Tongue | 2088 | 216 | 2304(56.5) | 5768 | 1465 | 7233(55.9) | 1977 | 327 | 2304(56.5) | 4905 | 2328 | 7233(55.9) | ||||
Buccal mucosa | 309 | 45 | 354(8.7) | 834 | 322 | 1156(8.9) | 283 | 71 | 354(8.7) | 661 | 495 | 1156(8.9) | ||||
Floor of mouth | 501 | 71 | 572(14) | 1407 | 422 | 1829(14.1) | 442 | 130 | 572(14) | 1046 | 783 | 1829(14.1) | ||||
Gum | 572 | 94 | 666(16.3) | 1405 | 481 | 1886(14.6) | 524 | 142 | 666(16.3) | 1090 | 796 | 1886(14.6) | ||||
Hard palate | 66 | 9 | 75(1.8) | 373 | 225 | 598(4.6) | 57 | 18 | 75(1.8) | 292 | 306 | 598(4.6) | ||||
Others | 92 | 15 | 107(2.6) | 142 | 97 | 239(1.8) | 85 | 22 | 107(2.6) | 106 | 133 | 239(1.8) | ||||
Surgery | < 0.001 | < 0.001 | ||||||||||||||
0.055 | < 0.001 | 0.007 | < 0.001 | |||||||||||||
No | 7 | 3 | 10(0.2) | 982 | 1157 | 2139(16.5) | 5 | 5 | 10(0.2) | 534 | 1605 | 2139(16.5) | ||||
Yes | 3621 | 447 | 4068(99.8) | 8947 | 1855 | 10,802(83.5) | 3363 | 705 | 4068(99.8) | 7566 | 3236 | 10,802(83.5) | ||||
Radiation | 0.027 | 0.027 | ||||||||||||||
0.014 | < 0.001 | 0.396 | < 0.001 | |||||||||||||
No | 2373 | 268 | 2641(64.8) | 8376 | 1873 | 10,249(79.2) | 2191 | 450 | 2641(64.8) | 6979 | 3270 | 10,249(79.2) | ||||
Yes | 1255 | 182 | 1437(35.2) | 1553 | 1139 | 2692(20.8) | 1177 | 260 | 1437(35.2) | 1121 | 1571 | 2692(20.8) | ||||
Chemotherapy | 1.000 | 1.000 | ||||||||||||||
< 0.001 | < 0.001 | < 0.001 | < 0.001 | |||||||||||||
No | 3382 | 386 | 3768(92.4) | 9394 | 2495 | 11,889(91.9) | 3144 | 624 | 3768(92.4) | 7730 | 4159 | 11,889(91.9) | ||||
Yes | 246 | 64 | 310(7.6) | 535 | 517 | 1052(8.1) | 224 | 86 | 310(7.6) | 370 | 682 | 1052(8.1) | ||||