Table 1 Demographics, Gingival crevicular fluid biomarker cytokine levels, Periodontal and X -ray and CBCT Variables for the Full cohort of post-menopausal women with and without HIV. Biomarkers were performed for Interferon Gamma (IFNγ), Tumor Necrosis Factor Alpha (TNFα), Interleukin (IL) 1 alpha, 2, 5, 6, 7, 8, 10, 12p70, 13, and 17 alpha, Osteoprotegrin (OPG) and Receptor Activator of Nuclear Factor Kappa Beta (RANKL). Abbreviations used are Trabecular (Trab.), Bone Volume (BV), Total Volume (TV), Cortical (Cort.) and Alveolar Crestal Height (ACH)

Age

0

57.04 (6.25)

57.15 (7.56)

56.95 (5.06)

0.8507

Race/Ethn

0

< 0.0001

Black

66 (48.89%)

14 (23.73%)

52 (68.42%)

Hispanic

57 (42.22%)

33 (55.93%)

24 (31.58%)

White

12 (8.89%)

12 (20.34%)

0 (0%)

Smoking

7

0.3730

No

90 (70.31%)

42 (72.41%)

48 (63.16%)

Yes

38 (29.69%)

14 (24.14%)

24 (31.58%)

Diabetes

5

0.1014

No

104 (80.0%)

49 (83.05%)

55 (72.37%)

Yes

26 (20.00%)

7 (11.86%)

19 (25%)

Biomarkers

pg/ml

# Not Detectable

Estadiol

20

38.29 (38.05)

43.0 (51.85)

35.16 (24.97)

0.2809

IFN g

23

1.42 (0.93)

1.44 (1.03)

1.4 (0.85)

0.8079

TNF a

20

1.32 (1.24)

1.35 (1.44)

1.3 (1.07)

0.8044

IL1 b

17

60.56 (65.58)

48.57 (56.31)

70 (71.05)

0.0780

IL2

20

0.56 (0.54)

0.5 (0.6)

0.6 (0.5)

0.3075

IL5

114

0.04 (0.03)

0.05 (0.05)

0.03 (0.01)

0.1627

IL6

21

0.71 (1.1)

0.54 (0.57)

0.85 (1.38)

0.1347

IL7

123

0.07 (0.05)

0.09 (0.05)

0.04 (0.02)

0.0749

IL8

17

586.87 (667.96)

514.26 (656.93)

644.07 (675.98)

0.2966

IL10

19

0.28 (0.25)

0.26 (0.24)

0.29 (0.25)

0.5288

IL12p70

75

0.26 (0.22)

0.31 (0.26)

0.23 (0.19)

0.2332

IL13

23

5.28 (3.35)

4.99 (3.58)

5.5 (3.18)

0.4245

IL17 a

56

0.58 (0.7)

0.6 (0.91)

0.57 (0.58)

0.8630

OPG

43

31.21 (28.55)

37.58 (42.88)

27.64 (15.12)

0.1099

RANKL

61

2.65 (3.02)

1.29 (2.14)

3.8 (3.19)

0.0002

Periodontal Variables

# Missing

Periodontitis

8

0.9966

Mild

7 (5.51%)

3 (5.08%)

4 (5.26%)

Moderate

45 (35.43%)

20 (33.90%)

25 (32.89%)

Severe

75 (59.06%)

33 (55.93%)

42 (55.26%)

Mean AL (mm)

10

3.49 (1.13)

3.58 (1.17)

3.41 (1.1)

0.3913

Mean PD (mm)

10

3.12 (0.92)

3.25 (1.01)

3.02 (0.83)

0.1657

% BOP

9

0.29 (0.26)

0.25 (0.23)

0.32 (0.28)

0.1680

# Teeth present

2

19.91 (7.28)

22.79 (5.7)

17.75 (7.62)

< 0.0001

X-ray and CBCT Variables

# Missing

Trab BV/TV %

25

54.26 (15.74)

52.22 (16.32)

55.68 (15.29)

0.2596

Thickness (Pixels)

25

6.85 (1.57)

6.24 (1.78)

7.27 (1.25)

0.0006

Number (1/Pixels)

25

0.08 (0.02)

0.09 (0.02)

0.08 (0.01)

0.0042

Separation (Pixels)

25

8.73 (3.21)

7.99 (3.23)

9.23 (3.11)

0.0450

Cort BV/TV %

25

98.91 (1.59)

98.53 (1.8)

99.18 (1.38)

0.0350

Cort % Porosity

25

1.09 (1.59)

1.47 (1.8)

0.82 (1.38)

0.0350

Mean ACH (mm)

7

3.03 (1.12)

2.72 (1.01)

3.26 (1.28)

0.0112