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Table 3 Bleeding scores according to the different sites and treatment group. C: Group control, CHX 0.12% MW; CX: Group test, CHX 0.09% + HA, polylysine, xylitol, and Citrox®; P: Group test, MW containing natural extracts

From: Use of over-the-counter mouthwashes as an additional measure in individual oral prophylaxis on adults with plaque-induced gingivitis: a double-blind, parallel, randomized controlled trial

Time

C

CX

P

Paired Comparisons

(p-Value)

 

n

% ± se

n

% ± se

n

% ± se

C-CX

C-P

CX-P

Total bleeding sites

T0(Baseline)

1818

39.31 ± 1.15

2628

36.87 ± 0.94

2016

39.04 ± 1.09

0.10

0.86

0.13

T1(2 weeks)

 

30.13 ± 1.08

 

27.09 ± 0.87

 

24.9 ± 0.96

0.03

0.00

0.09

p-value

 

0.00

 

0.00

 

0.00

   

Effect. T1, % (95%-CI)

 

23.36 ± 3.08

 

26.52 ± 2.51

 

36.21 ± 2.85

   

Anterior sites bleeding

T0(Baseline)

594

23.91 ± 1.75

864

24.07 ± 1.46

648

26.08 ± 1.73

0.94

0.38

0.37

T1(2 weeks)

 

18.69 ± 1.6

 

17.13 ± 1.28

 

14.66 ± 1.39

0.44

0.06

0.20

p-value

 

0.03

 

0.00

 

0.00

   

Effect. T1, % (95%-CI)

 

21.83 ± 4.66

 

28.85 ± 3.80

 

43.79 ± 4.35

   

Posterior sites bleeding

T0(Baseline)

1225

46.78 ± 1.43

1764

43.14 ± 1.18

1368

45.18 ± 1.35

0.06

0.41

0.25

T1(2 weeks)

 

35.67 ± 1.37

 

31.97 ± 1.11

 

29.75 ± 1.24

0.03

0.00

0.18

p-value

 

0.00

 

0.00

 

0.00

   

Effect. T1, % (95%-CI)

 

23.73 ± 3.88

 

25.89 ± 3.18

 

34.14 ± 3.58

   

Vestibular sites bleeding

T0(Baseline)

909

36.74 ± 1.6

1314

34.47 ± 1.13

1008

38.59 ± 1.53

0.27

0.40

0.04

T1(2 weeks)

 

32.12 ± 1.55

 

26.71 ± 1.22

 

20.34 ± 1.27

0.00

0.00

0.00

p-value

 

0.04

 

0.00

 

0.00

   

Effect. T1, % (95%-CI)

 

12.57 ± 4.37

 

22.52 ± 3.51

 

47.3 ± 3.90

   

Lingual sites bleeding

T0(Baseline)

910

41.87 ± 1.64

1314

39.27 ± 1.35

1008

39.48 ± 1.54

0.22

0.29

0.92

T1(2 weeks)

 

28.13 ± 1.49

 

27.47 ± 1.23

 

29.46 ± 1.44

0.73

0.52

0.30

p-value

 

0.00

 

0.00

 

0.00

   

Effect. T1, % (95%-CI)

 

32.81 ± 4.34

 

30.04 ± 3.58

 

25.38 ± 4.13

   

Maxillary sites bleeding

T0(Baseline)

906

36.42 ± 1.6

1320

32.2 ± 1.29

1008

38.89 ± 1.54

0.04

0.27

0.00

T1(2 weeks)

 

25.06 ± 1.44

 

20.53 ± 1.11

 

19.64 ± 1.25

0.01

0.00

0.60

p-value

 

0.00

 

0.00

 

0.00

   

Effect. T1, % (95%-CI)

 

31.21 ± 4.22

 

36.24 ± 3.33

 

49.49 ± 3.89

   

Mandibular sites bleeding

T0(Baseline)

913

42.17 ± 1.64

1308

41.59 ± 1.36

1008

39.19 ± 1.54

0.78

0.18

0.24

T1(2 weeks)

 

35.16 ± 1.58

 

33.72 ± 1.31

 

30.16 ± 1.45

0.48

0.02

0.07

p-value

 

0.00

 

0.00

 

0.00

   

Effect. T1, % (95%-CI)

 

16.62 ± 4.46

 

18.93 ± 3.70

 

23.04 ± 4.14

   
  1. *Effective size of the sample for each estimation. For instance, the first number value (n = 1818) is generated by the following calculation: 11 control subjects X 28 sites/patient X 6 sites/teeth = 1848 sites, minus sites with lack of tooth (n = 5), giving effective sample = 118 sites (= 1848 minus 30).