Fig. 6

CRS influence mitochondrial metabolism of OSCC by modulating ALDH3A1. a PCA score plot of tumor tissue-based metabolite profiling between the Con and CRS groups. b volcano plot of differentially metabolites (DMs). The threshold set for DMs was fold-changes (FC) > 2 and p < 0.05, 92 metabolites are downregulated (yellow) and 28 metabolites are upregulated (red). c KEGG pathway enrichment analysis of DMs. d mRNA expression of key mitochondrial metabolism factors in mice xenografts with Con and CRS groups. e mRNA expression of key mitochondrial metabolism factors in OSCC cells. f Relative levels of ATP production and OCR in HN6 and HSC4. g mRNA expression of key mitochondrial metabolism factors in mice xenografts with CRS + NC and CRS + Lv-ALDH3A1 groups. Data are expressed as mean ± SD; *, P < 0.05; **, P < 0.01; ***, P < 0.001