Table 3 Clinical characteristics of included studies at 6 months follow up

[20]

Group(I)

Group (II)

1.87 ± 0.74

2.60 ± 0.83

1.20 ± 1.47

1.20 ± 1.21

4.20 ± 0.77

4.33 ± 0.62

2.73 ± 1.44

2.60 ± 1.99

3.67 ± 0.98

3.60 ± 1.12

4.60 ± 1.59

4.80 ± 1.66

1.93 ± 0.70

1.93 ± 1.10

1.67 ± 0.82

1.93 ± 0.80

3.67 ± 1.11

4.33 ± 1.63

2.47 ± 1.36

2.87 ± 1.88

[21]

Group(I)

Group (II)

NR

NR

0.87 ± 0.35

0.93 ± 0.26

NR

NR

1.60 ± 0.63

1.33 ± 0.49

NR

NR

0.20 ± 0.41

0.33 ± 0.49

NR

1.07 ± 0.59

1.27 ± 0.59

[22]

Group(I)

Group (II)

3 ± 0.84

2.5 ± 0.84

0.4 ± 1.713

0.7 ± 1.713

NR

1.5 ± 0.388

2 ± 0.388

2.3 ± 1.466

3 ± 1.466

NR

NR

[16]

Group(I)

Group (II)

7.33 ± 1.44

7.00 ± 1.86

5.75 ± 1.14

5.00 ± 1.54

9.00 ± 1.71

9.08 ± 1.78

6.50 ± 1.51

6.92 ± 1.51

3.42 ± 0.51

3.33 ± 0.49

4.42 ± 0.51

4.75 ± 0.45

NR

NR

NR

NR

9.00 + 1.86

9.331 + 1.44

6.83 + 1.53

7.75 + 1.22

[23]

Group(I)

Group (II)

3.00 ± 0.667

3.20 ± 0.919

(at 3 months)1.10 ± 0.738

(at 3 months)0.70 ± 0.823

3.20 ± 0.789

2.40 ± 0.516

(at 3 months)1.40 ± 0.667

(at 3 months)0.50 ± 0.527

2.5 ± 0.632

2.82 ± 0.487

(at 3 months)3.53 ± 0.749

(at 3 months)3.6 ± 0.612

NR

11.10 ± 0.876

9.90 ± 3.28

(at 3 months)8.70 ± 1.252

(at 3 months)7.30 ± 2.452

[24]

Group(I)

Group (II)

NR

NR

NR

NR

NR

[25]

Group(I)

Group (II)

2.53 ± 0.83

2.60 ± 0.83

1.90 ± 1.54

1.67 ± 1.18

NR

NR

NR

NR

[15]

Group(I)

Group (II)

2.17–0.61

2.10–0.58

0.12–0.21

0.23–0.27

NR

NR

NR

NR

[26]

Group(I)

Group (II)

2.87 ± 0.9

2.63 ± 0.765

1.00 ± 0.00

1.43 ± 0.568

2.13 ± 0.776

2.47 ± 0.681

1.00 ± 0.000

1.20 ± 0.484

1.50 ± 0.731

1.73 ± 0.785

3.80 ± 0.551

2.43 ± 0.971

1.90 ± 0.803

1.87 ± 1.042

1.20 ± 0.407

1.40 ± 0.498

4.93 ± 1.143

4.50 ± 1.408

2.20 ± 0.407

2.83 ± 0.791

[14]

Group(I)

Group (II)

3.43 ± 1.741

4.12 ± 1.986

1.13 ± 1.452

1.88 ± 1.467

3.89 ± 1.192

4.38 ± 0.852

1.25 ± 0.496

2.93 ± 1.801

2.76 ± 1.664

2.39 ± 1.277

3.44 ± 1.298

3.34 ± 1.610

NR

4.99 ± 1.403

5.98 ± 2.055

2.64 ± 1.474

3.82 ± 1.593

[27]

Group(I)

Group (II)

8.00 ± 1.56

7.90 ± 1.52

7.00 ± 1.69

7.10 ± 1.37

NR

NR

NR

9.60 ± 2.22

9.50 ± 1.50

8.50 ± 2.01

8.40 ± 1.34

[28]

Group(I)

Group (II)

2.9 ± 0.87

2.5 ± 0.90

0.4 ± 0.51

0.3 ± 0.48

3.2 ± 0.42

3 ± 0.81

0.5 ± 0.52

0.40 ± 0.51

2.9 ± 0.73

3.0 ± 0.66

4.7 ± 0.67

4.3 ± 0.67

1.3 ± 0.48

1.2 ± 0.42

1.0 ± 0.0

1.1 ± 0.31

4.3 ± 1.15

3.6 ± 0.84

1.4 ± 0.51

1.3 ± 0.48

[29]

Group(I)

Group (II)

2.800 ± 0.862

2.733 ± 0.799

1.000 ± 1.000

1.400 ± 0.633

NR

NR

3.000 ± 0.535

2.733 ± 0.704

3.667 ± 0.488

3.267 ± 0.594

NR

NR

NR

NR

[30]

Group(I)

Group (II)

2.95 ± 0.89

2.70 ± 0.85

0.43 ± 0.45

0.50 ± 0.45

3.10 ± 0.41

3.20 ± 0.79

0.49 ± 0.50

0.55 ± 0.47

3.00 ± 0.75

3.10 ± 0.71

4.62 ± 0.22

4.62 ± 0.25

1.20 ± 0.49

1.20 ± 0.45

1.05 ± 0.12 1.13

± 0.39

4.40 ± 1.16

4.10 ± 0.89

1.53 ± 0.52 1.64

± 0.50

[31]

Group(I)

Group (II)

3.13 ± 0.4

3.43 ± 0.63

1.13 ± 1.26

0.8 ± 0.8

4.33 ± 0.84

4.5 ± 0.5

1.66 ± 1.67

2.1 ± 1.04

3.13 ± 0.3

3.53 ± 1.2

3.23 ± 0.32

3.53 ± 0.83

1.17 ± 0.56

1 ± 0.33

1.03 ± 0.3

0.86 ± 0.3

4.3 ± 0.62

4.43 ± 0.9

2.16 ± 1.31

1.66 ± 0.86

[32]

Group(I)

Group (II)

3.75 ± 0.62

3.91 ± 0.79

1.0 ± 0.60

1.50 ± 0.52

NR

NR

NR

NR

NR

NR

NR

NR

2.0 ± 0.42

1.66 ± 0.49

1.0 ± 0.00

1.3 ± 0.49

5.75 ± 0.86

5.58 ± 0.90

2.0 ± 0.60

2.83 ± 0.57

[33]

Group(I)

Group (II)

3.17 ± 0.83

3.08 ± 0.79

0.83 ± 0.80

1.25 ± 0.83

NR

NR

NR

NR

NR

NR

NR

NR

1.00 ± 0.00

1.04 ± 0.14

0.79 ± 0.33

0.79 ± 0.54

4.16 ± 0.83

4.12 ± 0.80

1.70 ± 0.86

1.90 ± 0.94

[34]

Group(I)

Group (II)

Mean (2.5)

Mean (2.5)

Mean (0.54)

Mean (1.5)

Mean (4)

Mean (4.83)

Mean (1.33)

Mean (3.5)

Mean (2.67)

Mean (2.54)

Mean (3.42)

Mean (2.83)

Mean (2.58)

Mean (2.25)

Mean (2.08)

Mean (2.17)

Mean (5.01)

Mean (4.42)

Mean (2.92)

Mean (3.83)

[17]

Group(I)

Group (II)

NR

NR

NR

NR

NR

NR

NR

NR

NR

1.33 ± 0.50

NR

2.22 ± 0.67

NR

NR

NR

NR

4.89 ± 0.78

4.56 ± 0.73

2.44 ± 0.88

3.67 ± 0.71

[35]

Group(I)

Group (II)

NR

NR

NR

1.400 ± 0.548

1.600 ± 0.548

(at 3 months)1.000 ± 0.000

(at 3 months)1.000 ± 0.000

4.110 ± 0.037

3.888 ± 0.425

(at 3 months)1.434 ± 0.408

(at 3 months)1.258 ± 0.375

[18]

Group(I)

Group (II)

(0-6 M)

1.80 ± 0.92

(0-6 M)

1.50 ± 1.53

(0-18 M)

1.90 ± 1.88

(0-18 M)

1.50 ± 1.53

(0-6 M)

0.30 ± 0.48

(0-6 M)

0.20 ± 0.42

(0-18 M)

1.30 ± 0.48

(0-18 M)

0.30 ± 0.48

(0-6 M)

1.10 ± 1.10

(0-6 M)

0.80 ± 1.03

(0-18 M)

0.90 ± 1.37

(0-18 M)

0.80 ± 1.03

(0–6 M)

0.20 ± 0.63

(0-6 M)

0.30 ± 1.34

(0–18 M)

0.20 ± 0.63

(0-18 M)

0.30 ± 1.34

(0-6 M)

1.50 ± 1.35

(0-6 M)

1.00 ± 1.05

(0–18 M)

1.60 ± 1.26

(0-18 M)

0.90 ± 1.20

[36]

Group(I)

Group (II)

Median = 4.00 (2.00–4.00)

Median =

3.00 (2.00–4.00)

Median = 1.00 (0.00–2.000

Median = 1.00 (0.00–2.00)

NR

NR

NR

NR

Median = 3.00 (2.00–4.00)

Median = 3.00 (2.00–4.00)

Median = 4.00 (3.00–5.00)

Median = 3.00(3.00–4.00)

Median = 2.00 (1.00–2.00)

Median = 1.00(1.00–2.00)

Median = 2.00 (2.00–3.00)

Median = 2.00 (1.00–3.00)

Median = 5.00 (4.00–6.00)

Median = 5.00 (4.00–6.00

Median = 3.00 (1.00–5.00)

Median = 3.00 (1.00–5.00)