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Fig. 4 | BMC Oral Health

Fig. 4

From: BML-111 inhibit H2O2-induced pyroptosis and osteogenic dysfunction of human periodontal ligament fibroblasts by activating the Nrf2/HO-1 pathway

Fig. 4

ML385 inhibit the effect of BML-111 on H2O2-induced pyroptosis in hPDLFs. Grouped as control, H2O2, H2O2 + BML-111, H2O2 + BML-111 + ML385

(A) Detection of intracellular ROS in hPDLFs by fluorescence staining. (B) The relative intracellular ROS in hPDLFs. (C) The pyroptosis rate of hPDLFs. (D) Flow cytometry detection of propidium iodide and annexin V fluorescein isothiocyanate (FITC) double-positive cells in hPDLFs. (E) The release of IL-1β, IL-18 and LDH from hPDLFs. **P < 0.01 compared with control group. ##P < 0.01 compared with H2O2 group. &&P < 0.01 compared with H2O2 + BML-111 group. *P < 0.05 compared with control group. #P < 0.05 compared with H2O2 group. &P < 0.05 compared with H2O2 + BML-111 group

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BMC Oral Health

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