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Fig. 5 | BMC Oral Health

Fig. 5

From: BML-111 inhibit H2O2-induced pyroptosis and osteogenic dysfunction of human periodontal ligament fibroblasts by activating the Nrf2/HO-1 pathway

Fig. 5

BML-111 reduced the expression of pyroptosis-related genes and proteins, and increased the expression of Nrf2 and HO-1 proteins in hPDLFs

(A) The NLRP3, ASC, Caspase-1, HO-1 mRNA relative expression was shown. (B) The NLRP3, ASC, Caspase-1, GSDMD-N, Total Nrf2, Nuclear Nrf2, HO-1 protein relative expression was shown. (C) Representative Western blots for NLRP3, ASC, Caspase-1, GSDMD-N, Total Nrf2, Nuclear Nrf2, HO-1 protein. **P < 0.01 compared with control group. ##P < 0.01 compared with H2O2 group. &&P < 0.01 compared with H2O2 + BML-111 group. nsP>0.05 compared with control group

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BMC Oral Health

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