Fig. 5
From: M2 macrophages-derived exosomes regulate osteoclast differentiation by the CSF2/TNF-α axis
M2-exos suppress osteoclast differentiation by regulating TNF-α. (A) The osteoclasts were treated with M2-exos and ADA, and the osteoclast-like cells were stained using the TRAP assay. The mRNA expression of (B) TRAP, (C) NFATC1, and (D) Cathepsin K was examined by qPCR. **P < 0.01 vs. the control group. ##P < 0.01 vs. the RANKL group. &&P < 0.01 vs. the RANKL + M2-exos group