Fig. 4
From: Oral cancer cell to endothelial cell communication via exosomal miR-21/RMND5A pathway
OSCC cell-derived exosomal miR-21 inhibits RMND5A gene expression of HUVECs. (a) Real-time PCR proves that miR-21 expression in HUVECs is upregulated after transfection with miR-21 mimic. (b) RMND5A gene expression is significantly decreased after overexpression of miR-21 using miR-21 mimic in HUVECs. (c, d) The condition media of miR-21 inhibitor transfected CAL27 (c) and SCC25 (d) cells cannot inhibit RMND5A expression of HUVECs. (e, f) The exosomes derived from miR-21 inhibitor transfected CAL27 (e) and SCC25 (f) had no significant effects on RMND5A gene expression of HUVECs. Data is expressed as mean ± SD. ns, not significant; *P < 0.05; **P < 0.01; ***P < 0.001