Fig. 3

Principal Coordinate Analysis (PCoA) and beta diversity. a PCoA. PC1 and PC2 dimensions represents 15.8 and 18.7% of the microbiome variation between data. According the PCoA, the sample groups are not significantly different (proven by PERMANOVA test, data not shown). Nevertheless, significant distinction is seen when the PLS Patients-A and -B (A and B, solid lines) are compared to the clinically healthy family member Subjects C-D-E (C, D, E, dashed lines) before and after treatment (T_A and T_B, dotted lines). b. Beta diversity. There were significant differences between the sample groups. Cutpoints are 0-0.001, 0-0.05, 0-1 and the corresponding symbols are “***”, “*”, “ns” (not significant)