Fig. 8

Comparison of PLS family microbiota and subgingival bacteria of periodontitis patients. The positions of subgingival microbiomes from PLS Patients-A/B and their healthy family members (Subjects-C-D-E) are shown, relative to a population of chronic periodontitis patients) [37, 38]. Numbers marking the anonymous individual patients and sampled tooth positions are highlighted in dark grey (=severe periodontitis), light grey (=periodontitis), and light blue (=healthy) backgrounds, according to their position on the major branches of the UPGMA tree (innermost ring #1). The microbiomes (orange) of the clinically healthy PLS family members map in the light grey area of Ring #2. The microbiomes of PLS Patients-A/B form a distinct branch (purple in Ring #1. Composition of microbial communities according to the Socransky complexes are indicated by the columns (outmost ring #3)