Table 3 Primary characteristics of the 14 studies included in this systematic review
From: Unlocking the potential of probiotic administration in caries management: a systematic review
Entry | Study | Study Desing | Participant number | Participant age (years) | Probiotic/Prebiotic | Administration vehicle | Frequency of administration | Intervention time |
|---|---|---|---|---|---|---|---|---|
1 | Campus et al., 2014 | RCT | 181 | 6–8 | Lactobacillus brevis CD2 | Lozenges | Two doses daily | 6 weeks of use + 2 weeks follow-up |
2 | Rungsri et al., 2017 | RCT | 41 | 20–25 | Lacticaseibacillus rhamnosus SD11 | Milk | One dose daily | 4 weeks of use + 8 weeks follow-up |
3 | Villavicencio et al., 2018 | RCT | 363 | 3–4 | Lacticaseibacillus rhamnosus, Bifidobacterium longum | Milk | One dose 5 times per week | 9 months |
4 | Angarita-DÃaz et al., 2019 | Quasi-experimental pilot study | 63 | 3–5 | Lacticaseibacillus rhamnosus, Bifidobacterium longum | Milk | One dose 5 times per week | 3 months |
5 | Zare Javid et al., 2019 | RCT | 66 | 18–30 | Bifidobacterium lactis Bb12 | Yogurt | One dose daily | 2 weeks |
6 | Manmontri et al., 2019 | RCT | 286 | 1–5 | Lactobacillus paracasei SD1 | Milk | One dose daily or three times per week | 6 months of use + 6 months follow-up |
7 | Ferrer et al., 2019 | RCT | 59 | 18–65 | Streptococcus dentisani | Bucco-adhesive gel | Every 48 h | 4 weeks of used + 2 weeks follow-up |
8 | Gedam et al., 2019 | RCT | 51 | 8–12 | Lacticaseibacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium longum, Saccharomyces boulardii | Mouth rinse | One dose daily | 2 weeks of use + 4 weeks follow-up |
9 | Shaalan et al., 2021 | RCT | 96 | > 65 | Bifidobacterium, Xylitol | Yogurt/chewing gum | One dose daily (for Yogurt) or three doses daily (for chewing gum) | 3 months |
10 | Wattanarat et al., 2021 | RCT | 286 | 1–5 | Lactobacillus paracasei SD1 | Milk | One dose daily or 3 times per week | 6 months of use + 6 months follow-up |
11 | Piwat et al., 2020 | RCT | 469 | 1–5 | Lactobacillus paracasei SD1 | Milk | One dose daily or 3 times per week | 6 months of use + 6 months follow-up |
12 | Ratna Sudna et al., 2020 | RCT | 48 | 5–15 | Bacillus coagulans Unique IS2 | Oral tablets | One dose daily | 2 weeks |
13 | Gandhi et al., 2020 | RCT | 60 | 7–10 | Cinnamon Bark Oil, Lacticaseibacillus rhamnosus, Lactobacillus plantarum | Mucoadhesive pacth | Two times per day | 2 weeks |
14 | Sandovalet et al., 2021 | RCT | 42 | 2–3 | Lactobobacillus rhamnosus SP1 | Milk | One dose daily | 10 months |