Table 11 Marginal mean Turesky Plaque Index (TPI), Modified Gingival Index (MGI) and Expanded Bleeding Index (EBI) at Baseline, Week 4 and Week 12

Marginal Mean Turesky Plaque Index (TPI)

Baseline

n

53

51

52

50

52

Mean

2.80

2.68

2.73

2.85

2.74

(SD)

0.473

0.610

0.462

0.508

0.553

Week 4

N

53

51

52

50

52

LSmean (SE)

2.59 (0.060)

1.48 (0.062)

1.73 (0.061)

2.49 (0.062)

1.74 (0.061)

Treatment groups versus B

p-value

< 0.001

< 0.001

0.225

< 0.001

Difference (SE)

-1.11 (0.086)

-0.86 (0.086)

-0.11 (0.086)

-0.85 (0.086)

95% CI

[-1.28, -0.94]

[-1.03, -0.69]

[-0.28, 0.07]

[-1.02, -0.68]

% reduction

42.8

33.2

4.1

32.9

Brush/Rinse groups versus BF Superiority

p-value

< 0.001

< 0.001

Difference (SE)

-1.01 (0.088)

-0.75 (0.087)

95% CI

[-1.18, -0.83]

[-0.93, -0.58]

% reduction

40.4

30.3

BFZ versus BF Superiority

p-value

< 0.001

Difference (SE)

-0.75 (0.087)

95% CI

[-0.92, -0.58]

% reduction

30.0

BFZ versus BZ

p-value

0.934

Difference (SE)

0.01 (0.086)

95% CI

[-0.16, 0.18]

% reduction

-0.4

Week 12

N

52

50

52

50

50

LSmean (SE)

2.51 (0.060)

1.31 (0.061)

1.58 (0.060)

2.58 (0.061)

1.64 (0.061)

Treatment groups versus B

p-value

< 0.001

< 0.001

0.447

< 0.001

Difference (SE)

-1.21 (0.085)

-0.94 (0.085)

0.07 (0.085)

-0.87 (0.085)

95% CI

[-1.38, -1.04]

[-1.10, -0.77]

[-0.10, 0.23]

[-1.04, -0.71]

% reduction

48.1

37.2

-2.6

34.8

Brush/Rinse groups versus BF Superiority

p-value

< 0.001

< 0.001

Difference (SE)

-1.27 (0.087)

-1.00 (0.086)

95% CI

[-1.44, -1.10]

[-1.17, -0.83]

% reduction

49.4

38.8

BFZ versus BF Superiority

p-value

< 0.001

Difference (SE)

-0.94 (0.086)

95% CI

[-1.11, -0.77]

% reduction

36.4

BFZ versus BZ Superiority

p-value

0.470

Difference (SE)

0.06 (0.085)

95% CI

[-0.11, 0.23]

% reduction

-3.9

Marginal Mean Modified Gingival Index (MGI)

Baseline

n

53

51

52

50

52

Mean

2.40

2.42

2.52

2.43

2.50

(SD)

0.366

0.375

0.366

0.332

0.332

Week 4

N

53

51

52

50

52

LSmean

2.44 (0.054)

1.47 (0.055)

1.46 (0.055)

2.24 (0.056)

1.43 (0.055)

Treatment groups versus B

p-value

< 0.001

< 0.001

0.011

< 0.001

Difference (SE)

-0.97 (0.077)

-0.98 (0.077)

-0.20 (0.078)

-1.00 (0.077)

95% CI

[-1.12, -0.81]

[-1.13, -0.83]

[-0.35, -0.05]

[-1.16, -0.85]

% reduction

39.6

40.2

8.1

41.2

Brush/Rinse groups versus BF Superiority

p-value

< 0.001

< 0.001

Difference (SE)

-0.77 (0.078)

-0.78 (0.078)

95% CI

[-0.92, -0.61]

[-0.94, -0.63]

% reduction

34.3

34.9

BFZ versus BF Superiority

p-value

< 0.001

Difference (SE)

-0.81 (0.078)

95% CI

[-0.96, -0.65]

% reduction

36.0

BFZ versus BZ

p-value

0.766

Difference (SE)

-0.02 (0.077)

95% CI

[-0.18, 0.13]

% reduction

1.6

Week 12

N

52

50

52

50

50

LSmean (SE)

2.38 (0.057)

1.14 (0.058)

1.20 (0.057)

2.23 (0.058)

1.27 (0.058)

Treatment groups versus B

p-value

< 0.001

< 0.001

0.072

< 0.001

Difference (SE)

-1.24 (0.082)

-1.17 (0.081)

-0.15 (0.082)

-1.11 (0.082)

95% CI

[-1.40, -1.08]

[-1.33, -1.01]

[-0.31, 0.01]

[-1.27, -0.94]

% reduction

52.2

49.3

6.2

46.5

Brush/Rinse groups versus BF Superiority

p-value

< 0.001

< 0.001

Difference (SE)

-1.09 (0.082)

-1.03 (0.082)

95% CI

[-1.26, -0.93]

[-1.19, -0.86]

% reduction

49.0

46.0

BFZ versus BF Superiority

p-value

< 0.001

Difference

-0.96 (0.082)

95% CI

[-1.12, -0.80]

% reduction

43.0

BFZ versus BZ Superiority

p-value

0.413

Difference (SE)

0.07 (0.082)

95% CI

[-0.09, 0.23]

% reduction

-5.5

Marginal Mean Expanded Bleeding Index (EBI)

Baseline

n

53

51

52

50

52

Mean

0.312

0.319

0.364

0.344

0.335

(SD)

0.1929

0.1762

0.1928

0.1897

0.2029

Week 4

N

53

51

52

50

52

LSmean

0.260 (0.0123)

0.107 (0.0125)

0.104 (0.0124)

0.225 (0.0126)

0.106 (0.0124)

Treatment groups versus B

p-value

< 0.001

< 0.001

0.045

< 0.001

Difference (SE)

-0.153 (0.0175)

-0.156 (0.0175)

-0.035 (0.0176)

-0.155 (0.0175)

95% CI

[-0.187, -0.118]

[-0.191, -0.122]

[-0.070, -0.001]

[-0.189, -0.120]

% reduction

58.7

60.1

13.6

59.4

Brush/Rinse groups versus BF Superiority

p-value

< 0.001

< 0.001

Difference (SE)

-0.117 (0.0178)

-0.121 (0.0177)

95% CI

[-0.152, -0.082]

[-0.156, -0.086]

% reduction

52.2

53.8

BFZ versus BF Superiority

p-value

< 0.001

Difference (SE)

-0.119 (0.0177)

95% CI

[-0.154, -0.084]

% reduction

53.0

BFZ versus BZ

p-value

0.918

Difference

0.002 (0.0175)

95% CI

[-0.033, 0.036]

% reduction

-1.8

Week 12

N

52

50

52

50

50

LSmean (SE)

0.288 (0.0142)

0.102 (0.0144)

0.117 (0.0142)

0.226 (0.0145)

0.103 (0.0144)

Treatment groups versus B

p-value

< 0.001

< 0.001

0.003

< 0.001

Difference (SE)

-0.186 (0.0202)

-0.171 (0.0201)

-0.062 (0.0203)

-0.185 (0.0202)

95% CI

[-0.226, -0.146]

[-0.211, -0.132]

[-0.102, -0.022]

[-0.225, -0.146]

% reduction

64.5

59.4

21.4

64.4

Brush/Rinse groups versus BF Superiority

p-value

< 0.001

< 0.001

Difference (SE)

-0.124 (0.0205)

-0.110 (0.0203)

95% CI

[-0.164, -0.084]

[-0.150, -0.070]

% reduction

54.8

48.4

BFZ versus BF Superiority

p-value

< 0.001

Difference (SE)

-0.124 (0.0204)

95% CI

[-0.164, -0.084]

% reduction

54.6

BFZ versus BZ Superiority

p-value

0.483

Difference (SE)

-0.014 (0.0203)

95% CI

[-0.054, 0.026]

% reduction

12.2