Table 2 Interproximal mean Turesky Plaque Index (TPI) at Baseline, Weeks 4, 12

Baseline

n

53

51

52

50

52

Mean

3.20

3.13

3.14

3.28

3.18

(SD)

0.382

0.413

0.329

0.369

0.386

Week 4

N

53

51

52

50

52

LSmean (SE)

3.08 (0.043)

2.23 (0.044)

2.53 (0.043)

3.05 (0.044)

2.56 (0.043)

Treatment groupss versus B

p-value

< 0.001

< 0.001

0.696

< 0.001

Difference (SE)

-0.85 (0.061)

-0.55 (0.061)

-0.02 (0.061)

-0.51 (0.061)

95% CI

[-0.97, -0.73]

[-0.67, -0.43]

[-0.14, 0.10]

[-0.63, -0.39]

% reduction

27.5

17.9

0.8

16.7

Brush/Rinse groups versus BF Superiority

p-value

Difference (SE)

95% CI

% reduction

< 0.001

-0.82 (0.062)

[-0.94, -0.70]

26.9

< 0.001

-0.53 (0.062)

[-0.65, -0.40]

17.2

BFZ group versus BF Superiority

p-value Difference (SE)

95% CI % reduction

< 0.001

-0.49 (0.062)

[-0.61, -0.37]

16.1

BFZ versus BZ

p-value

Difference (SE)

95% CI

% reduction

0.557

0.04 (0.061)

[-0.08, 0.16]

-1.4

Week 12

n

52

50

52

50

50

LSmean (SE)

2.97 (0.042)

2.05 (0.043)

2.43 (0.042)

3.05 (0.043)

2.49 (0.042)

Treatment groups versus B

p-value

< 0.001

< 0.001

0.164

< 0.001

Difference (SE)

-0.91 (0.059)

-0.54 (0.059)

0.08 (0.060)

-0.48 (0.059)

95% CI

[-1.03, -0.80]

[-0.66, -0.42]

[-0.03, 0.20]

[-0.59, -0.36]

% reduction

30.8

18.2

-2.8

16.0

BZ Rinse versus BF Non-inferiority

p-value

< 0.001

BA versus BF Non-inferiority

p-value

< 0.001

BA versus BF Superiority

p-value

Difference (SE)

95% CI

% reduction

< 0.001

-1.00 (0.061)

[-1.11, -0.88]

32.6

BZ versus BF Superiority

p-value

Difference (SE)

95% CI

% reduction

< 0.001

-0.62 (0.060)

[-0.76, -0.49]

20.4

BFZ versus BF Superiority

p-value

Difference (SE)

97.5% CI

% reduction

< 0.001

-0.56 (0.060)

[-0.69, -0.42]

18.3

BFZ versus BZ Superiority

p-value

Difference (SE)

95% CI

% reduction

0.278

0.065 (0.059)

[-0.05, 0.18]

-2.7