Table 3 Interproximal mean Modified Gingival Index (MGI) at Baseline, Weeks 4, 12

Baseline

n

53

51

52

50

52

Mean

2.74

2.72

2.80

2.74

2.79

(SD)

0.270

0.286

0.226

0.225

0.208

Week 4

N

53

51

52

50

52

LSmean (SE)

2.73 (0.047)

1.94 (0.048)

1.93 (0.048)

2.59 (0.049)

1.88 (0.048)

Treatment groups versus B

p-value

< 0.001

< 0.001

0.041

< 0.001

Difference (SE)

-0.79 (0.068)

-0.80 (0.067)

-0.14 (0.068)

-0.85 (0.067)

95% CI

[-0.93, -0.66]

[-0.93, -0.67]

[-0.27, -0.01]

[-0.98, -0.72]

% reduction

29.0

29.3

5.1

31.2

Brush/Rinse groups versus BF Superiority

p-value

Difference (SE)

95% CI

% reduction

< 0.001

-0.65 (0.069)

[-0.79, -0.52]

25.2

< 0.001

-0.66 (0.068)

[-0.80, -0.53]

25.5

BFZ versus BF Superiority

p-value

Difference (SE)

95% CI

% reduction

< 0.001

-0.71 (0.068)

[-0.85, -0.58]

27.5

BFZ versus BZ

p-value

Difference (SE)

95% CI

% reduction

0.462

-0.05 (0.068)

[-0.18, 0.803]

2.6

Week 12

n

52

50

52

50

50

LSmean (SE)

2.67 (0.052)

1.63 (0.053)

1.68 (0.053)

2.55 (0.053)

1.71 (0.053)

Treatment groups versus B

p-value

< 0.001

< 0.001

0.111

< 0.001

Difference (SE)

-1.04 (0.075)

-0.99 (0.074)

-0.12 (0.074)

-0.96 (0.075)

95% CI

[-1.19, -0.89]

[-1.13, -0.89]

[-0.27, 0.03]

[-1.11, -0.82]

% reduction

39.0

36.9

4.5

36.1

BZ versus BF Non-inferiority

p-value

Difference

< 0.001

BA versus BF Non-inferiority

p-value

< 0.001

BA versus BF Superiority

p-value

Difference (SE)

95% CI

% reduction

< 0.001

-0.92 (0.075)

[-1.07, -0.77]

36.2

BZ versus BF Superiority

p-value

Difference (SE)

95% CI

% reduction

< 0.001

-0.87 (0.075)

[-1.04, -0.70]

34.0

BFZ versus BF Superiority

p-value

Difference (SE)

97.5% CI

% reduction

< 0.001

-0.84 (0.076)

[-1.01, -0.67]

33.1

BFZ versus BZ Superiority

p-value

Difference (SE)

95% CI

% reduction

0.770

0.02 (0.075)

[-0.13, 0.17]

-1.3