Table 9 Whole mouth mean Expanded Bleeding Index (EBI) at Baseline, Weeks 4, 12

Baseline

n

53

51

52

50

52

Mean

0.307

0.304

0.366

0.343

0.319

(SD)

0.1868

0.1695

0.1946

0.1741

0.1856

Week 4

N

53

51

52

50

52

LSmean (SE)

0.229 (0.0097)

0.079 (0.0099)

0.076 (0.0099)

0.168 (0.0100)

0.067 (0.0098)

Treatment groups versus B

p-value

< 0.001

< 0.001

< 0.001

< 0.001

Difference (SE)

-0.150 (0.0139)

-0.153 (0.0139)

-0.061 (0.0140)

-0.162 (0.0138)

95% CI

[-0.177, -0.123]

[-0.180, -0.126]

[-0.089, -0.034]

[-0.189, -0.134]

% reduction

65.6

66.9

26.7

70.7

Brush/Rinse groups versus BF Superiority

p-value

< 0.001

< 0.001

Difference (SE)

-0.089 (0.0141)

-0.092 (0.0140)

95% CI

[-0.117, -0.061]

[-0.120, -0.064]

% reduction

53.1

54.9

BFZ versus BF Superiority

p-value

< 0.001

Difference (SE)

-0.100 (0.0140)

95% CI

[-0.128, -0.073]

% reduction

60.0

BFZ versus BZ

p-value

0.539

Difference (SE)

-0.009 (0.0139)

95% CI

[-0.036, 0.019]

% reduction

11.3

Week 12

N

52

50

52

50

50

LSmean (SE)

0.257 (0.0121)

0.086 (0.0123)

0.081 (0.0121)

0.185 (0.0123)

0.067 (0.0123)

Treatment group versus B

p-value

< 0.001

< 0.001

< 0.001

< 0.001

Difference

-0.170 (0.0172)

-0.176 (0.0172)

-0.071 (0.0173)

-0.190 (0.0172)

95% CI

[-0.204, -0.137]

[-0.210, -0.142]

[-0.105, -0.037]

[-0.224, -0.156]

% reduction

66.4

68.5

27.8

73.9

Brush/Rinse groups versus BF Superiority

p-value

< 0.001

< 0.001

Difference (SE)

-0.099 (0.0174)

-0.104 (0.0173)

95% CI

[-0.134, -0.065]

[-0.139, -0.070]

% reduction

53.5

56.4

BFZ versus BF Superiority

p-value

< 0.001

Difference (SE)

-0.118 (0.0174)

95% CI

[-0.153, -0.084]

% reduction

63.8

BFZ versus BZ Superiority

p-value

0.426

Difference (SE)

-0.014 (0.0173)

95% CI

[-0.048, 0.020]

% reduction

17.1