Table 1 Pathway enrichment analysis in increased, decreased and variable expression groups

Increased Expression Groups

Gene Amount in Pathway

Differentially Expressed Genes Counts in Pathway

P value

Rap1 signaling pathway

207

50

1.6333E-08

Axon guidance

178

45

1.9548E-08

Proteoglycans BR

55

21

7.3175E-08

Focal adhesion

209

46

1.0866E-06

ECM-receptor interaction

92

26

2.066E-06

Dilated cardiomyopathy (DCM)

85

24

5.1477E-06

Adherens junction

70

21

7.0027E-06

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

68

20

1.599E-05

PI3K-Akt signaling pathway

372

66

1.8009E-05

Pathways in cancer

533

86

4.3892E-05

Hippo signaling pathway

155

33

7.019E-05

Hypertrophic cardiomyopathy (HCM)

82

21

9.5678E-05

Ras signaling pathway

230

43

1.55E-04

Phospholipase D signaling pathway

147

30

3.21E-04

Glycosaminoglycan binding proteins BR

214

39

5.22E-04

Parathyroid hormone synthesis, secretion and action

106

23

6.34E-04

Fluid shear stress and atherosclerosis

146

29

6.39E-04

Vascular smooth muscle contraction

140

28

7.02E-04

Ribosome

248

43

8.18E-04

cGMP-PKG signaling pathway

170

32

9.11E-04

Decreased Expression Groups

Gene Amount in Pathway

Differentially Expressed Genes Counts in Pathway

P value

Measles

134

53

1.63E-15

Toll-like receptor signaling pathway

104

45

4.32E-15

Osteoclast differentiation

125

50

6.06E-15

Influenza A

183

63

8.96E-15

Chemokine signaling pathway

179

60

1.52E-13

NF-kappa B signaling pathway

93

40

1.84E-13

B cell receptor signaling pathway

67

33

2.17E-13

Epstein-Barr virus infection

226

69

3.98E-13

NOD-like receptor signaling pathway

175

58

6.68E-13

Hepatitis B

145

51

1.27E-12

C-type lectin receptor signaling pathway

103

40

9.61E-12

Acute myeloid leukemia

66

30

3.57E-11

Leishmaniasis

86

35

4.01E-11

Chronic myeloid leukemia

79

33

6.27E-11

Tuberculosis

200

59

9.60E-11

FoxO signaling pathway

133

45

1.19E-10

T cell receptor signaling pathway

100

37

2.97E-10

Kaposi sarcoma-associated herpesvirus infection

194

56

7.13E-10

Apoptosis

145

46

8.37E-10

Non-small cell lung cancer

64

27

2.64E-09

Variable Expression Groups

Gene Amount in Pathway

Differentially Expressed Genes Counts in Pathway

P value

DNA replication proteins BR

130

22

2.58E-08

Chromosome and associated proteins BR

1207

86

8.85E-07

DNA repair and recombination proteins BR

316

32

4.66E-06

Cellular senescence

169

21

9.75E-06

Homologous recombination

45

10

1.47E-05

Cell cycle

130

17

3.52E-05

Prostate cancer

93

13

1.46E-04

Wnt signaling pathway

147

17

1.67E-04

Breast cancer

151

17

2.31E-04

Fanconi anemia pathway

53

9

3.53E-04

Basal cell carcinoma

65

10

3.85E-04

Gastric cancer

156

16

9.81E-04

DNA replication

39

7

1.13E-03

Glycosaminoglycan binding proteins BR

214

19

1.95E-03

Endometrial cancer

58

8

2.98E-03

Pancreatic cancer

76

9

4.78E-03

Hepatocellular carcinoma

174

15

7.32E-03

Bladder cancer

42

6

8.19E-03

Hepatitis B

145

13

8.83E-03

PI3K-Akt signaling pathway

372

26

8.90E-03