Efficacy of an experimental toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride on gingivitis

Axe, Alyson; Patel, Nisha; Qaqish, Jimmy; Ling, Martin R.; Araga, Mako; Parkinson, Charlie; Goyal, Chaju Ram

doi:10.1186/s12903-024-03981-9

Table 3 Summary of statistical analysis for NBS, BI, MGI and TPI endpoints

From: Efficacy of an experimental toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride on gingivitis

Comparison between groups^a	Parameter	Visit	Adjusted mean difference (SE)^b	95% CI^b	Percentage difference^c	p-value^d
Experimental toothpaste (n = 36) versus negative control toothpaste (n = 38)	NBS	Day 3 Week 1 Week 2 Week 6	-2.0 (0.48) -5.2 (0.75) -8.9 (1.07) -11.0 (1.12)	-3.0, -1.1 -6.7, -3.8 -11.1, -6.8 -13.3, -8.8	-7.1 -19.9 -38.8 -53.8	0.6284 0.0029 < 0.0001 < 0.0001
	BI	Day 3 Week 1 Week 2 Week 6	-0.023 (0.0049) -0.043 (0.0061) -0.059 (0.0075) -0.070 (0.0066)	-0.032, -0.013 -0.055, -0.030 -0.074, -0.044 -0.083, -0.057	-11.59 -24.35 -39.96 -54.57	0.9769 0.0105 < 0.0001 < 0.0001
	MGI	Day 3 Week 1 Week 2 Week 6	-0.048 (0.0095) -0.117 (0.0141) -0.205 (0.0201) -0.305 (0.0286)	-0.067, -0.030 -0.145, -0.089 -0.245, -0.165 -0.362, -0.248	-2.36 -5.77 -10.61 -16.58	0.0720 < 0.0001 < 0.0001 < 0.0001
	TPI (overall)	Day 3 Week 1 Week 2 Week 6	-0.042 (0.0321) -0.068 (0.0410) -0.161 (0.0466) -0.252 (0.0386)	-0.106, 0.022 -0.150, 0.014 -0.254, -0.068 -0.329, -0.175	-1.8 -3.0 -7.5 -11.9	0.7516 0.4290 0.0876 0.0008
	TPI (interproximal)	Day 3 Week 1 Week 2 Week 6	-0.048 (0.0348) -0.057 (0.0431) -0.131 (0.0463) -0.248 (0.0373)	-0.117, 0.022 -0.143, 0.029 -0.224, -0.039 -0.322, -0.174	-2.0 -2.5 -6.0 -11.4	0.7355 0.8315 0.2724 0.0006
Experimental toothpaste (n = 36) versus positive control toothpaste (n = 36)	NBS	Day 3 Week 1 Week 2 Week 6	0.4 (0.63) 0.8 (0.89) 1.0 (1.02) 0.4 (1.01)	-0.8, 1.7 -1.0, 2.6 -1.0, 3.0 -1.6, 2.4	1.5 3.8 7.2 4.2	0.5579 0.2009 0.5139 0.4488
	BI	Day 3 Week 1 Week 2 Week 6	-0.002 (0.0048) -0.001 (0.0067) 0.007 (0.0068) 0.003 (0.0063)	-0.012, 0.008 -0.014, 0.013 -0.007, 0.020 -0.009, 0.016	-1.10 -0.64 7.70 5.64	0.6531 0.8321 0.3952 0.3639
	MGI	Day 3 Week 1 Week 2 Week 6	0.021 (0.0109) 0.009 (0.0185) 0.066 (0.0295) -0.032 (0.0337)	-0.001, 0.042 -0.028, 0.046 0.007, 0.125 -0.100, 0.035	1.03 0.48 3.93 -2.03	0.7858 0.3416 0.1355 0.2630
	TPI (overall)	Day 3 Week 1 Week 2 Week 6	0.006 (0.0301) 0.026 (0.0343) 0.059 (0.0355) 0.045 (0.0361)	-0.055, 0.066 -0.043, 0.094 -0.012, 0.130 -0.027, 0.117	0.2 1.2 3.0 2.5	0.4707 0.0986 0.0299 0.1615
	TPI (interproximal)	Day 3 Week 1 Week 2 Week 6	0.008 (0.0337) 0.023 (0.0383) 0.063 (0.0352) 0.023 (0.0360)	-0.060, 0.075 -0.053, 0.100 -0.008, 0.133 -0.048, 0.095	0.3 1.0 3.1 1.2	0.3712 0.0729 0.0141 0.2069
Positive control toothpaste (n = 36) versus negative control toothpaste (n = 38)	NBS	Day 3 Week 1 Week 2 Week 6	-2.4 (0.57) -6.1 (0.86) -9.8 (1.29) -11.5 (1.18)	-3.5, -1.3 -7.8, -4.4 -12.4, -7.2 -13.8, -9.1	-8.3 -23.0 -42.6 -55.8	0.5544 0.0008 < 0.0001 < 0.0001
	BI	Day 3 Week 1 Week 2 Week 6	-0.022 (0.0050) -0.044 (0.0067) -0.067 (0.0093) -0.074 (0.0077)	-0.032, -0.012 -0.057, -0.030 -0.086, -0.049 -0.090, -0.059	-11.19 -24.57 -45.42 -57.27	0.8981 0.0104 < 0.0001 < 0.0001
	MGI	Day 3 Week 1 Week 2 Week 6	-0.065 (0.0091) -0.125 (0.0156) -0.262 (0.0265) -0.281 (0.0306)	-0.083, -0.046 -0.156, -0.093 -0.315, -0.209 -0.342, -0.220	-3.13 -6.12 -13.53 -15.18	0.0124 < 0.0001 < 0.0001 < 0.0001
	TPI (overall)	Day 3 Week 1 Week 2 Week 6	-0.048 (0.0333) -0.110 (0.0333) -0.220 (0.0340) -0.295 (0.0342)	-0.114, 0.019 -0.176, -0.044 -0.288, -0.152 -0.363, -0.227	-2.0 -4.8 -10.3 -14.0	0.6576 0.0390 < 0.0001 < 0.0001
	TPI (interproximal)	Day 3 Week 1 Week 2 Week 6	-0.053 (0.0367) -0.095 (0.0354) -0.192 (0.0359) -0.269 (0.0334)	-0.126, 0.021 -0.166, -0.025 -0.264, -0.120 -0.335, -0.202	-2.2 -4.2 -8.8 -12.5	0.7204 0.1379 < 0.0001 < 0.0001

^a Difference is mean NBS, BI, MGI and TPI for first product minus second product (experimental minus negative control; experimental minus positive control; and positive control minus negative control), such that a negative difference favors the first product (experimental or positive control). ^b Analysis was performed using ANCOVA model with the following factors: For NBS: study product group and gender as factors and baseline NBS as covariate; for BI: study product group, gender and NBS strata as factors, and baseline BI score as covariate; for MGI: study product group, gender and NBS strata as factors, and baseline MGI score as covariate; for TPI (overall): study product group, gender and NBS strata as factors and baseline overall TPI score as covariate; for TPI (interproximal): study product group, gender and NBS strata as factors and baseline interproximal TPI score as covariate
^c Percentage difference calculated as (adjusted mean difference/adjusted mean of comparison toothpaste)*100. ^dp-value from Van Elteren test (non-parametric)
ANCOVA, analysis of covariance; BI, Bleeding Index; CI, confidence interval; MGI, Modified Gingival Index, NBS, number of bleeding sites; SE, standard error; TPI, Turesky Plaque Index

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ISSN: 1472-6831

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