Fig. 2
From: Characterization and application of in situ curcumin/ZNP hydrogels for periodontitis treatment
Transcriptional response pattern of the gingiva of rats after treatment with Cur/ZNP hydrogels. (A). Transcriptional patterns of the gingiva of rats treated with different hydrogels showing clear divergence as determined by principal component analysis. (B) Cluster and (C) heatmap of differentially expressed genes (DEGs) obtained by pairwise comparison. The scaled counts of the transcripts are marked on the right. (D) Changes in GO terms (adjusted P < 0.05) between the sham and EP groups. The colors of the circles correspond to the functional terms on the right. The DEGs are significantly enriched in the immune effector process GO terms, as shown in the box. Cur, curcumin; ZNP, zinc oxide nanoparticle; GO, Gene Ontology; EP, experimental periodontitis