Fig. 5
From: Characterization and application of in situ curcumin/ZNP hydrogels for periodontitis treatment
Effect of the Cur/ZNP hydrogel on bone metabolism in rats with experimental periodontitis. (A). The effect of the Cur/ZNP hydrogel on OCN in the alveolar bone of rats was determined by immunohistochemical staining. (B). The effect of the Cur/ZNP hydrogel on OPG in the alveolar bone of rats was determined by immunohistochemical staining. The black arrows indicate the staining of positive cells. Quantitative analysis of OCN+ cells (C) and OPG+ cells (D) in each group. (E). Serum OCN levels were detected by an enzyme-linked immunosorbent assay. The data are presented as the mean ± standard deviation (n = 5 rats per group). a, Compared with the sham group; *P < 0.05; b, compared with the EP group, *P < 0.05; c, compared with the Cur gel group, *P < 0.05; d, compared with the ZNP gel group, *P < 0.05. Cur, curcumin; ZNP, zinc oxide nanoparticle; EP, experimental periodontitis; OCN, osteocalcin; OPG, osteoprotegerin