Table 3 Characteristics of the biomarkers assessed
Author/Year | GCF Sampling | Biomarker Assessment | Type of Assay/ Kit | Biomarkers Mean Value/(SD) | Main Findings |
|---|---|---|---|---|---|
Nair et al., 2022 [28] | Volumetric microcapillary pipette extracrevicular | IL-17 | ELISA (RayBiotech) | IL-17 (pg/mL) HC: 11.56(0.99)* G: 19.27(2.78)* CP: 99.67(18.85)** | ↑ Subjects with CP, and G In CP, IL-17 was + correlated with CAL (*p < 0.05) |
Wankhede, and Dhadse, 2022 [29] | Volumetric microcapillary pipette extracrevicular | IL-17 | ELISA (Diaclone) | IL-17 (pg/mL) HC: 0.64(0.23)* CP: 1.96(1.71)** | ↑ Subjects with CP In CP, IL-17 was + correlated with CAL (*p < 0.05) |
Nainee et al., 2020 [30] | Paper points | IL-17 | ELISA | IL-17 (pg/mL) HC: 8.19(7.61)* G: 122.35(172.11)* CP: 178.71(199.32)** | ↑ Subjects with CP, and G In G, and CP, IL-17 was + correlated with GI, PD, and CAL (*p < 0.001) |
Sadeghi et al., 2018 [31] | Paper strips | IL-17, IL-23 | ELISA (Bender Med Systems) | IL-17 (pg/mL) HC: 22.81(23.63)** CP: 1.46(1.20)* IL-23 (pg/mL) HC: 186.55(183.51)** CP: 91.21(1.0)* | ↓ Subjects with CP Also, a + correlation was found between the levels of both cytokines, (*p < 0.001), but there were no significant correlations with periodontal clinical parameters (*p > 0.001) |
Kalate et al., 2018 [32] | Paper strips | IL-17 | ELISA | IL-17 (pg/mL) HC: 38.18(11.23)* CP: 53.46(45)** | ↑ Subjects with CP (*p < 0.001) |
Althebeti et al., 2018 [33] | Paper strips | IL-23 | ELISA | IL-23 (pg/mL) HC: 27.26(19.74)* G: 42.57(4.47)* CP: 107.01(53.50)** | ↑ Subjects with P, and G IL-23 was + correlated with PI in CP (*p < 0.001) |
Mitani et al., 2015 [34] | Paper strips | IL-17 | ELISA | IL-17 (pg/mL) HC: 6.51(4.71)* CP: 23.37(6.62)** | ↑ Subjects with CP In CP, IL-17 was + correlated with PD, and CAL (*p < 0.05) |
Himani et al., 2014 [35] | Paper strips | IL-23 | ELISA (eBioscince) | IL-23 (pg/mL) HC: 0.66(0.32)* G: 4.01(1.3)* CP: 10.19(4.8)** | ↑ Subjects with CP, and G (*p < 0.05) |
Nagireddy et al., 2013 [36] | Volumetric microcapillary pipette extracrevicular | IL-17 | ELISA (Quantikine® R&D systems) | IL-17 (pg/mL) HC: 36.87(10.50)* CP: 54.75(12.35)** | ↑ Subjects with CP In CP, IL-17 was + correlated with PD (*p < 0.001) |
Shaker et al., 2012 [37] | Paper strips | IL-17 | ELISA (BioSource) | IL-17 (pg) HC: 30.5(3.8)* CP: 37.4(8.8)** | ↑ Subjects with CP (*p < 0.001) |
Ay et al., 2009 [38] | Paper strips | IL-17 | ELISA (BioSource) | IL-17 (pg) HC: 14.05(1.0) CP: 11.62(1.0) | No significan differences were found among the groups in the total amount of IL-17 |
Vernal et al., 2005 [39] | Paper strips | IL-17 | ELISA (Quantikine® R&D Systems) | IL-17 (pg) HC: 35.6(2.4)* CP: 45.9(17.4)** | ↑ Subjects with CP (*p < 0.001) |