The association between Dental Fluorosis and COL1A2 gene polymorphism among a Tunisian Population

BMC Oral Health

Table 2 Allelic frequencies of rs412777 of COL1A2 gene in the studied population

	All subjects		Control group (44)		Case group (51)		P value	OR (95% CI)
Allele	N	Frequency	N	Frequency	N	Frequency
C	98	0.52	34	0.39	64	0.63	0.001	0.37 (0.21–0.67)
A	92	0.48	54	0.61	38	0.37	0.001	0.37 (0.21–0.67)

The distribution of various genotypes exhibited statistically significant differences between the control and case groups (Table 3). Upon conducting Odds Ratio analysis, it was determined that the AA genotype may be considered protective against DF in both codominant and dominant genetic models ((P = 0.002; OR = 0.18 (0.06–0.55) and P < 0.001; OR = 0.19 (0.07–0.52) respectively)

ISSN: 1472-6831