Table 3 Differences in mean changes over time for levels of serum biomarkers in smokers (n = 30) compared with non-smokers (n = 30)

IL-6

unadjusted

T1 – T0 =

0.008 (-0.042;0.059)

0.952

T2 – T0 =

-0.003 (-0.064;0.059)

0.997

T2 – T1 =

-0.011 (-0.078;0.056)

0.952

adjusted^a

T1 – T0 =

0.009 (-0.042;0.059)

0.947

T2 – T0 =

-0.002 (-0.063;0.059)

0.998

T2 – T1 =

-0.011 (-0.078;0.057)

0.953

adjusted^b

T1 – T0 =

0.009 (-0.043;0.061)

0.947

T2 – T0 =

-0.008 (-0.070;0.054)

0.965

T2 – T1 =

-0.017 (-0.085;0.051)

0.884

IL-8

unadjusted

T1 – T0 =

0.005 (-0.776;0.786)

0.999

T2 – T0 =

-0.331 (-1.126;0.464)

0.718

T2 – T1 =

-0.336 (-1.018;0.346)

0.630

adjusted^a

T1 – T0 =

0.011 (-0.775;0.797)

0.999

T2 – T0 =

-0.320 (-1.117;0.477)

0.735

T2 – T1 =

-0.331 (-1.015;0.353)

0.640

adjusted^b

T1 – T0 =

0.046 (-0.749;0.840)

0.994

T2 – T0 =

-0.301 (-1.116;0.515)

0.771

T2 – T1 =

-0.346 (-1.042;0.349)

0.624

IL-10

unadjusted

T1 – T0 =

0.180 (-0.009;0.369)

0.183

T2 – T0 =

-0.108 (-0.310;0.095)

0.586

T2 – T1 =

-0.288 (-0.494;-0.081)

0.030

adjusted^a

T1 – T0 =

0.180 (-0.010;0.370)

0.186

T2 – T0 =

-0.106 (-0.315;0.104)

0.617

T2 – T1 =

-0.286 (-0.497;-0.075)

0.036

adjusted^b

T1 – T0 =

0.182 (-0.008;0.372)

0.180

T2 – T0 =

-0.126 (-0.333;0.082)

0.501

T2 – T1 =

-0.308 (-0.517;-0.099)

0.021

TNF-α

unadjusted

T1 – T0 =

0.512 (-0.057;1.082)

0.220

T2 – T0 =

-0.518 (-1.103;0.068)

0.232

T2 – T1 =

-1.030 (-1.713;-0.347)

0.017

adjusted^a

T1 – T0 =

0.512 (-0.061;1.085)

0.224

T2 – T0 =

-0.518 (-1.107;0.072)

0.236

T2 – T1 =

-1.030 (-1.718;-0.342)

0.018

adjusted^b

T1 – T0 =

0.514 (-0.067;1.096)

0.232

T2 – T0 =

-0.413 (-0.974;0.149)

0.361

T2 – T1 =

-0.927 (-1.598;-0.256)

0.032

IP-10

unadjusted

T1 – T0 =

24.958 (-54.441;104.358)

0.828

T2 – T0 =

30.324 (-58.002;118.651)

0.798

T2 – T1 =

5.366 (-67.843;78.575)

0.990

adjusted^a

T1 – T0 =

26.282 (-55.058;107.621)

0.819

T2 – T0 =

33.339 (-57.683;124.361)

0.774

T2 – T1 =

7.057 (-66.007;80.121)

0.982

adjusted^b

T1 – T0 =

14.221 (-64.400;92.841)

0.939

T2 – T0 =

20.729 (-66.204;107.663)

0.897

T2 – T1 =

6.509 (-67.839;80.857)

0.985

CRP

unadjusted

T1 – T0 =

0.594 (-0.273;1.460)

0.412

T2 – T0 =

0.425 (-0.546;1.396)

0.694

T2 – T1 =

-0.169 (-0.891;0.553)

0.901

adjusted^a

T1 – T0 =

0.590 (-0.281;1.462)

0.420

T2 – T0 =

0.426 (-0.551;1.402)

0.696

T2 – T1 =

-0.165 (-0.893;0.564)

0.907

adjusted^b

T1 – T0 =

0.547 (-0.338;1.432)

0.484

T2 – T0 =

0.364 (-0.629;1.358)

0.774

T2 – T1 =

-0.183 (-0.917;0.551)

0.888