Towards microbiome transplant as a therapy for periodontitis: an exploratory study of periodontitis microbial signature contrasted by oral health, caries and edentulism

Table 2 Bacterial species that had significantly different abundances (%) between individuals with the non-periodontitis (NP; e.g., healthy, caries, edentulous) and periodontitis (P) abundances based on Mann–Whitney test (alpha = 0.05)

Phylum/class	Genus/species	NP	P
Actinobacteria	Atopobium vaginae	0.01	0.35*
	Actinomyces georgiae	0.05	0.35**
	Actinomyces meyeri	0.10	0.49**
Bacteroidetes	Porphyromonas endodontalis	0.12	2.91*
	uncultured Porphyromonas sp.	0.04	1.26*
	Porphyromonas gingivicanis	0.00	0.04**
	Tannerella forsythia	0.20	0.83*
	Prevotella intermedia	0.12	3.23*
	Prevotella pallens	0.14	0.85*
	Prevotella pleuritidis	0.00	0.01**
	Prevotella salivae	0.20	0.74**
Firmicutes/Clostridia	Parvimonas micra	0.12	1.19*
	Eubacterium saburreum	0.07	0.28*
	Pseudobutyrivibrio xylanivorans	0.00	0.06*
	Peptostreptococcus anaerobius	0.07	0.50*
Firmicutes/Negativicutes	Megasphaera micronuciformis	0.12	0.92*
Fusobacteria	Leptotrichia wadei	0.10	0.32**
Proteobacteria/Deltaproteobacteria	uncultured Desulfobulbus sp.	0.00	0.02*
Proteobacteria/Epsilonproteobacteria	Campylobacter rectus	0.03	0.14*
	Campylobacter concisus	0.03	0.07**
Spirochaetes/Spirochaetales	Treponema denticola	0.07	1.60*
	Treponema maltophilum	0.01	0.25*
	Treponema medium	0.03	0.29*
	Treponema socranskii	0.05	0.21*
	Treponema sp.	0.03	0.10*
	Treponema vincentii	0.07	0.71*
	Treponema pectinovorum	0.00	0.04**
Synergistetes	Synergistetes bacterium SGP1	0.05	0.23*
	Aminobacterium colombiense	0.01	0.05*

*Significant difference using both normalization methods (i.e., raw species abundances were log2 transformed, normalized to produce relative values ((raw values-average)/std) versus abundances normalized to the total number of reads in a sample)
**Significant difference for abundances using data normalized only to the total number of reads in a sample

ISSN: 1472-6831