Towards microbiome transplant as a therapy for periodontitis: an exploratory study of periodontitis microbial signature contrasted by oral health, caries and edentulism

Table 3 Microbial species that had significantly different abundances (%) between individuals with the non-healthy (NH; periodontitis, caries, edentulous) and healthy (H) abundances based on Mann–Whitney test (alpha = 0.05)

Phylum/class	Genus/species	NH	H
Actinobacteria	Micrococcus lylae	0.00	0.03**
Bacteroidetes	Prevotella marshii	0.01	0.09**
Firmicutes/Bacilli	Abiotrophia para-adiacens	0.22	0.60**
	Granulicatella elegans	0.20	0.66*
	Granulicatella adiacens	0.60	1.27**
	Streptococcus iniae	0.04	0.15*
Firmicutes/Negativicutes	Selenomonas ruminantium	0.00	0.10*
Proteobacteria/Betaproteobacteria	Neisseria polysaccharea	0.00	0.02*
Proteobacteria/Gammaproteobacteria	Aggregatibacter segnis	0.01	0.21**
	Haemophilus parainfluenzae	0.17	0.46*

*Significant difference determined using both normalization methods (i.e., raw species abundances were log2 transformed, normalized to produce relative values ((raw values-average)/std) versus abundances normalized to the total number of reads in a sample)
**Significant difference for abundances using data that was normalized to only the total number of reads in a sample

ISSN: 1472-6831