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Management of Dentin Hypersensitivity by National Dental Practice-Based Research Network practitioners: results from a questionnaire administered prior to initiation of a clinical study on this topic

  • Dorota T. Kopycka-Kedzierawski1Email author,
  • Cyril Meyerowitz1,
  • Mark S. Litaker2,
  • Sidney Chonowski3,
  • Marc W. Heft4,
  • Valeria V. Gordan4,
  • Robin L. Yardic5,
  • Theresa E. Madden6,
  • Stephanie C. Reyes7,
  • Gregg H. Gilbert2 and
  • National Dental PBRN Collaborative Group
BMC Oral HealthBMC series – open, inclusive and trusted201717:41

Received: 26 July 2016

Accepted: 6 January 2017

Published: 13 January 2017



Dentin hypersensitivity (DH) is a common problem encountered in clinical practice. The purpose of this study was to identify the management approaches for DH among United States dentists.


One hundred eighty five National Dental Practice-Based Research Network clinicians completed a questionnaire regarding their preferred methods to diagnose and manage DH in the practice setting, and their beliefs about DH predisposing factors.


Almost all dentists (99%) reported using more than one method to diagnose DH. Most frequently, they reported using spontaneous patient reports coupled with excluding other causes of oral pain by direct clinical examination (48%); followed by applying an air blast (26%), applying cold water (12%), and obtaining patient reports after dentist’s query (6%). In managing DH, the most frequent first choice was desensitizing, over-the-counter (OTC), potassium nitrate toothpaste (48%), followed by fluorides (38%), and glutaraldehyde/HEMA (3%). A total of 86% of respondents reported using a combination of products when treating DH, most frequently using fluoride varnish and desensitizing OTC potassium nitrate toothpaste (70%). The most frequent predisposing factor leading to DH, as reported by the practitioners, was recessed gingiva (66%), followed by abrasion, erosion, abfraction/attrition lesions (59%) and bruxism (32%).


The majority of network practitioners use multiple methods to diagnose and manage DH. Desensitizing OTC potassium nitrate toothpaste and fluoride formulations are the most widely used products to manage DH in dental practice setting.


Dentin hypersensitivityNational Dental Practice-Based Research Network


Dentin hypersensitivity (DH) has been defined as a “short, sharp pain arising from exposed dentin in response to stimuli, typically thermal, evaporative, tactile, osmotic or chemical, and that cannot be ascribed to any other form of dental defect or pathology” [1]. One of the most frequent patient complaints is related to cold stimuli, although pain may also occur when consuming acidic foods (mainly fruit), sweets and salty foods. Tactile stimulus provocation frequently occurs when patients brush their teeth or rub the sensitive area with a finger nail [2].

DH is a relatively common problem encountered in clinical practice. It may disturb patients during eating, drinking and brushing. The prevalence of DH has been reported to be in the range of 8 to 57% [1, 311]. The wide range could be related to different methods used to diagnose this condition and whether prevalence was assessed by clinical examination and/or questionnaires [12].

For example, among 780 patients from the Health Examination Center of National Taiwan University Hospital, the prevalence of DH was 32% [9]. The self-reported prevalence of DH among regular attenders in three general dental practices in the United Kingdom was 52%; DH was most prevalent among 30–40 year old patients and it was more common among female patients [10]. A cross-sectional study conducted by 19 dental practitioners in the United Kingdom examined 4841 patients in one calendar month and found that 4.1% of patients were diagnosed with DH based on the dentist examination. Upper premolars were the most commonly affected, and cold drinks initiated DH most often. More sensitive teeth were found in patients with periodontal disease who also smoked [13].

Based on a cross-sectional survey of 787 adult patients from 37 general dental practices within the Northwest PRECEDENT Practice Based-Research Network (PBRN), the prevalence of DH was 12.3% [11]. Patients with hypersensitivity had, on average, 3.5 hypersensitive teeth. The prevalence was highest among patients who were 18–44 years of age and lowest among patients who were 65 years of age or older. The prevalence was higher among women, patients with gingival recession and patients who used at home tooth whitening products [11].

No clear consensus among Northwest PRECEDENT dentists existed for successfully treating DH, but fluoride varnishes and gels apparently were most widely employed. Dentists also expressed high levels of interest in testing fluoride varnishes and gels, as well as glutaraldehyde/HEMA and restorative treatments, in future studies [14].

DH affects patients of any age with its peak occurrence in middle-aged adults. It may affect any tooth, but most often affects canines and first premolars, probably because they are prominent in the arch and they are exposed to higher pressure during tooth brushing. It may present clinically on any tooth surface, but most often occurs on the buccal cervical margins of teeth. Several theories of DH have been proposed. These include hydrodynamic, odontoblast transduced mechanism and direct innervation theories [7]. None of these mechanisms fully explain this phenomenon. Although dentin sensitivity appears to be prevalent, no universally used or highly reliable desensitizing agents or treatment modalities have been identified [15, 16].

Recently the Practitioners Engaged in Applied Research and Learning Network (PEARL Network) conducted a randomized clinical trial in the practice setting to assess the outcomes of noncarious cervical lesion treatment choices [17]. The overall objective was to determine the efficacy of three randomly assigned treatments for hypersensitive noncarious lesions: chemoactive dentifrice use, dentin bonding agent with sealing and flowable resin-based composite restoration. The secondary outcomes were tubule occlusion, retention of resin coating, retention of restoration and change in lesion size. Results suggest that placement of the sealant or resin restoration was effective in reducing hypersensitive noncarious cervical lesions over the 6-month study period.

According to a survey of dental practitioners conducted by the Canadian Advisory Board on Dentin Hypersensitivity, approximately 50% of the respondents reported lack of confidence in managing patients’ pain due to DH [1]. The Canadian Advisory Board on Dentin Hypersensitivity suggested that providers initiate management of this condition by applying desensitizing treatment that is noninvasive; i.e., desensitizing toothpaste and/or topical agents. Some dental providers use a stepped approach to treatment with multiple visits; others apply and prescribe multiple treatments at one time. Invasive treatments of DH are also performed by placing a restoration on an otherwise healthy tooth [1].

Although DH has been studied previously in the practice-based research setting, there have been wide differences among clinicians as to the methods used to diagnose and manage DH; furthermore the prior data were constrained to one region of the US. Therefore, the purpose of this study was to identify in a broader national context the preferred methods to diagnose and manage DH in the practice setting and to assess practitioners’ beliefs about DH predisposing factors. In addition, we assessed whether practitioner and practice characteristics were associated with practitioners’ selected treatments and approaches to care.


As an initial phase of a prospective, multicenter cohort study of patients with DH, 185 National Dental Practice-Based Research Network (National Dental PBRN) clinicians answered an online questionnaire related to the diagnostic methods, treatment modalities and predisposing factors of DH. The questionnaire is publicly available and it is enclosed in a supplementary file with the manuscript [18]. The current paper reports the results of the online questionnaire that was administered prior to initiation of a cohort study on this topic. The network is a consortium of dental practices and organizations that participate in clinical research studies and comprises six regions across the US [18, 19].

Initially, the study investigators pilot tested the questionnaire with six practitioners to assess its length, acceptability, and internet browser compatibility. Based on practitioner feedback, the study investigators administered a revised questionnaire to 24 additional practitioners to quantify test-retest reliability for 94 items (text items were not evaluated). Agreement between responses was calculated for each of 24 practitioners. For each practitioner, if there was no response for an item at both test and retest, this item was not included in the evaluation. Percentage agreement was calculated as the number of items for which the test and retest responses were the same, divided by the number of items for which the practitioner provided responses, multiplied by 100. Descriptive statistics were calculated for the practitioner-level agreement values. The mean number of items for which responses were provided was 37.63, minimum 19, maximum 48. The mean number of items showing agreement was 24.33, minimum 13, maximum 33. The mean agreement across the 24 practitioners was 65.01%. The minimum and maximum agreement for individual practitioners was 45.65 and 100%. The questionnaire was not modified after testing. The test-retest questionnaires were completed in February 2015. Practitioners also complete an enrollment questionnaire that describes characteristics about themselves and their practice(s). Selected questions from the enrollment questionnaire were used to explore which characteristics were associated with practitioners’ treatments and approaches to DH care. Practitioner variables included: age, gender, race/ethnicity and dental specialty. Practice variables included: practice size, location and practice type.

The study participants were invited to enroll in the study in March 2015. Any National Dental PBRN practitioner (i.e., general dentist and specialist) who was enrolled in the network at the full participation level was eligible to participate in the study. One hundred eighty five practitioners were study-ready by the end of July 2015, having completed all necessary human subjects and conflict of interest training as required by the National Dental PBRN procedures.

Statistical Analysis

Sample size considerations were based on precision of estimation of percentages, represented by the widths of 95% confidence intervals adjusted for the effect of clustered sampling due to enrolment of multiple patients per dental practice. Adjustment for clustering used variance inflation factors calculated for a range of likely values of intracluster correlation (ICC). Power to detect a difference between proportions of dentists using each of the treatment modalities was estimated based on cluster-adjusted chi-square tests to approximate the power of the proposed GEE analysis. Based on this analysis, the target sample size of the study was set at 180 practitioners.

Descriptive statistics including frequencies, means, medians, standard deviations and quartiles were calculated. The chi-square and Fisher’s exact tests were used to compare distributions of categorical variables. Analysis of variance and the Kruskal-Wallis test were used for the analysis of continuous variables. The Tukey and Wilcoxon rank sums tests were used for post-hoc comparisons. The analysis was conducted using SAS® Release 9.4 statistical software. P-values less than 0.05 were considered statistically significant.


Practitioners’ characteristics, practice location and practice type

Among the 185 practitioners who completed the questionnaire, 34 represented the Western region, 29 represented the Midwest region, 30 represented the Southwest region, 30 represented the South Central region and 31 practitioners each represented the South Atlantic and Northeast regions of the National Dental PBRN. Table 1 summarizes practitioners’ characteristics, practice location and type. One hundred nineteen practitioners were male (64%) and 66 (36%) were female. The majority (79%) identified themselves as White, 4% as African-American, 10% as Asian and 7% as other racial category. Practitioners’ ages differed significantly by network region (p = 0.02). Practitioners in the Northeast and the South Central regions were the oldest (mean (SD) age of 56.1 (11.15) years) and practitioners from the South Atlantic region were the youngest (mean (SD) age of 48.7 (12.17) years; p = 0.02, ANOVA).
Table 1

Characteristics of participating practitioners and their practice(s) (N = 185)

Practitioner and practice characteristics



N (%)


119 (64)


66 (36)


N (%)


146 (79)




18 (10)


12 (7)


Years (SD)


52 (11.4)





Practice location


 Inner City of Urban Area


 Urban Area






Practice type


 Owner of a private practice


 Associate/employee of a private practice


 Health Partners Dental Group


 Permanente Dental Associates


 Other managed care/preferred provider


 Public health practice


 Dental School/academic institution



N (%)

 General Dentist

173 (94)


12 (6)

Diagnosis of Dentin Hypersensitivity

Table 2 summarizes the most frequent methods practitioners reported using when diagnosing DH. Spontaneous patient report confirmed by the dental examination, was chosen most frequently as the first choice (48%). This was followed by applying air blast (26%), scratching dentin with a dental explorer (12%), patient report after dentist’s query (6%), using other methods, most likely applying endo-ice (4%), and applying cold water (2%).
Table 2

Most frequent choices used when diagnosing DH (N = 182)

Most frequent methods used when diagnosing DH

N (%)

Spontaneous patient report confirmed by the dental exam

88 (48)

Applying air blast

47 (26)

Scratching dentin with dental explorer

22 (12)

Obtaining patient report after dentist’s query

11 (6

Other (most likely using endo ice)

8 (4)

Applying cold water

4 (2)

Requesting numeric rating of pain

2 (1)

Treatment Modalities

As shown in Table 3, the practitioners reported using multiple products when managing DH. Almost all practitioners (97%) reported routine use of fluoride formulations, followed by desensitizing over-the-counter (OTC) potassium nitrate toothpaste (94%). Glutaraldehyde/HEMA products were reported as being used routinely by 42% participating in the survey. Interestingly, bonding agents and restorative treatments were reported to be used routinely respectively by 52 and 64% of the practitioners when treating DH.
Table 3

Treatment modalities routinely used when treating Dentin Hypersensitivity (Practitioners had options to check multiple answers)

Treatment modality

N (%)

Fluoride formulations (gels, varnishes, pasted and rinses)

180 (97)

Desensitizing over-the counter (OTC) potassium nitrate toothpastes

173 (94)

Glutaraldehyde/HEMA products

78 (42)

Bonding agents

97 (52)


30 (16)

Restorative treatments

119 (64)


6 (3)


21 (11)


41 (22)


35 (19)

As shown in Table 4, practitioners reported that the most frequent, practitioner reported, first choice of products used when managing DH was: OTC potassium nitrate toothpaste (48%), followed by fluoride formulations (38%) and glutaraldehyde/HEMA products (3%). Four percent of the practitioners reported giving advice (i.e., related to diet and dental habits) to their patients as their first choice of treatment modality. A total of 86% of the respondents reported using a combination of products when treating DH, most frequently fluoride varnish and desensitizing OTC potassium nitrate toothpaste (70%).
Table 4

Most frequent products used when managing DH (these were first choices of products indicated by the practitioners)

Most frequent products used when managing DH

N (%)

OTC potassium nitrate toothpaste

88 (48)

Fluoride formulations

70 (38)

Giving advice (related to diet and dental habits)

7 (4)


7 (4)


6 (3)

No treatment

2 (1)

Restorative treatments

1 (2)

Bonding agents

1 (.5)


1 (.5)


1 (.5)

Predisposing Factors

As summarized in Table 5, practitioners indicated their first choice of potential factors that may be related to dentin hypersensitivity. Recessed gingiva was chosen by 66% of the practitioners, followed by abrasion, erosion, abfraction and/or attrition lesions (59%). Thirty two percent indicated that bruxism contributes to DH and that it was their first choice of predisposing factors. Excessive tooth whitening and frequent consumption of citric juices and/or carbonated drinks were chosen by 17 and 15% of practitioners, respectively, as first choices for predisposing factors of DH.
Table 5

Most frequent predisposing factors of DH as indicated by the practitioners (Practitioners indicated their first choice of predisposing factors)

Predisposing factor

N (%)

Recessed gingiva

122 (66)

Abrasion, erosion, abfraction and/or attrition lesions

109 (59)


59 (32)

Excessive tooth whitening

31 (17)

Frequent consumption of citrus juices and/or carbonated drinks

28 (15)

Diagnosis, management and predisposing factors, by network region and practitioners’ characteristics

Practitioners’ diagnostic and management methods did not differ significantly across the six network regions. There were no age differences in diagnostic methods, except for using “other methods” to diagnose DH (p < 0.0001, Fisher’s exact test). Only 2% of practitioners in the younger age category (younger than 55 years) indicated using “other methods”, compared to 20% in the older age category (55 years of age and older). Most of the responses in the “other” category suggested using soft bristle toothbrushes, recommending gingival grafting, occlusal adjustments, and fabricating occlusal guards.

There were no practitioner gender differences in diagnostic methods, except when using an explorer (p = 0.015, Fisher’s exact test). More male dentists than female dentists use a dental explorer to diagnose DH (84 versus 68%).

There were no regional differences in dentists’ beliefs regarding predisposing factors to DH, except for bruxism (p = 0.047, chi-square test). The highest percentage of practitioners from the South Atlantic region (87%) had chosen bruxism as one of the predisposing factors of DH; the lowest percentage was chosen by practitioners from the Western region (53%).

The practice locations did not differ significantly across the 6 regions, however the practice type did differ significantly by region (p < 0.0001, chi-square test). Almost 87% of practitioners from the Southwest and the South Central regions identified themselves as owners of a private practice, 83% practitioners from the South Atlantic region, 74% practitioners from the Northeast region, 59% practitioners from the Western region and 52% of practitioners from the Midwest region.


These results suggest that when diagnosing DH practitioners most frequently rely on spontaneous patient report, confirmed by the dental examination, followed by applying an air blast and scratching dentin with a dental explorer. Our finding is consistent with the 2008–2009 study by Northwest PRECEDENT practitioners, which suggested that the most frequently reported diagnostic method was spontaneous patient report [14]. Patient reports, prompted by a query from the dentist, were also common, but used less frequently. Additionally, dentists employed a dental explorer or air blast to assess DH [14]. Our findings indicate that practitioners confirm their patients’ reports with a dental examination to diagnose DH. The diagnosis of DH is thus made by excluding other oral conditions that may explain pain and discomfort in the oral cavity.

These findings also suggest that fluoride formulations and OTC potassium nitrate toothpastes were the most frequent products used to treat DH. Almost 97% of practitioners reported routinely using fluoride formulations and 94% reported routinely using OTC potassium nitrate toothpastes. Almost half (48%) used OTC potassium nitrate toothpaste and 38% used fluoride formulations as their first choice when treating DH. This finding is consistent with the PRECEDENT study, wherein dentists reported using fluoride formulations most commonly and it was the only treatment modality used by more than 50% of respondents. Almost half the PRECEDENT dentists (47%) reported using OTC potassium nitrate toothpastes when managing DH [14]. Our findings also suggest that 86% of respondents used a combination of products when treating DH, most frequently using fluoride varnish and desensitizing OTC potassium nitrate toothpaste (70%); suggesting that most practitioners combine in-office treatment with at-home treatment.

When reporting predisposing factors of DH, 66% of practitioners reported that recessed gingiva was their first choice, followed by abrasion, erosion, abfraction and/or attrition lesions (59%) and bruxism (32%). This finding is supported by the most accepted theory related to DH, the hydrodynamic theory, which proposes that stimuli (thermal, physical or osmotic changes) cause displacement of the fluid that exists within the dentinal tubules and this mechanical disturbance activates the nerve endings in the pulp [20]. This requires that the dentin must be exposed to the oral cavity. In addition to using fluoride varnish and desensitizing OTC potassium nitrate toothpaste, the majority of practitioners indicated restorative treatments when managing DH, most likely restoring abfraction lesions. Older practitioners were more likely than younger practitioners to report occlusal adjustments and fabricating occlusal guards as “other” treatment when managing DH.

Regarding practitioner and practice characteristics that are associated with managing DH, our results suggest that younger and older dentists use similar methods when diagnosing DH. More male practitioners than female practitioners reported using a dental explorer when diagnosing DH. Practitioners 55 years of age or older more often suggested gingival grafting, occlusal adjustments and fabrication of occlusal guards when indicating treatment options used for DH. One of the possible explanations that older practitioners suggested more options when managing DH could be that they had more experience in managing DH than younger practitioners. There are regional differences in beliefs regarding predisposing factors for DH. Most practitioners from the South Atlantic region (87%) indicated bruxism as one of the predisposing factors, while only 53% dentists from the Western region reported this.

Practitioners reported using similar methods when diagnosing and managing DH in their offices, regardless of their practice location, practice type, and network region. As mentioned above, there were a few differences in diagnostic methods and treatment options offered when comparing younger to older practitioners and male to female practitioners; however, the differences were not significantly different between the six network regions.

This study does have some limitations; and interpretation of its conclusions should take these into account. This study relied on questionnaire data rather than direct observation of clinical procedures. Although network practitioners have much in common with dentists at large, it is possible that their reports on diagnosis and treatment of DH and their beliefs about DH predisposing factors are not representative of dentists at large [21, 22]. Additionally, network members are not recruited randomly; their participation in the network (e.g., an interest in participating in clinical research studies) may make them unrepresentative of dentists at large. While we cannot assert that network dentists are entirely representative of US dentists, we can state that they have much in common with dentists at large, while also offering substantial diversity in these characteristics. This assertion is warranted because: 1) substantial percentages of network dentists are represented in the various response categories of the characteristics in the Enrollment Questionnaire; 2) findings from several network studies document that network dentists report patterns of diagnosis and treatment that are similar to patterns determined from non-network dentists [2325] and 3) the similarity of network dentists to non-network dentists using the best available national source, the 2010 ADA Survey of Dental Practice [26].


The majority of network practitioners use multiple methods to diagnose and manage DH. Desensitizing OTC potassium nitrate toothpaste and fluoride formulations are the most widely reported products used to manage DH in the practice setting. The majority reported that recessed gingiva, followed by the abrasion/erosion; abfraction/attrition lesions and bruxism most likely contribute to DH.



Management of dentin hypersensitivity

National Dental PBRN: 

National Dental Practice-Based Research Network



An Internet site devoted to details about the nation’s network is located at We are very grateful to the network’s Regional Coordinators who worked with network practitioners to conduct the study:

Kimberly Johnson, RDH, MDH; Midwest Region

Stephanie Hodge, MA; Western Region

Rita Cacciato, RHD, MS; Northeast Region

Deborah McEdward, RDH, BS, CCRP; South Atlantic Region

Claudia Carcelén, MPH, Shermetria Massengale, MPH, CHES, Ellen Sowell, BA; South Central Region

Meredith Buchberg, MPH, Colleen Steward MPH; Southwest Region

Camille Baltuck, RDH; Western Region

Opinions and assertions contained herein are those of the authors and are not to be construed as necessarily representing the views of the respective organizations or the National Institutes of Health.

National Dental PBRN Collaborative Group:

The National Dental PBRN Collaborative Group comprises practitioner, faculty, and staff investigators who contributed to this network activity. A list of these persons is at; University of Alabama at Birmingham, Birmingham, AL.


This work was supported by NIH/NIDCR grant U-19-DE-22516.

Availability of data and materials

The study questionnaire is available as a supplementary file and also it is available on a public webpage:

The National Dental PBRN makes publicly available data from its studies after the grant’s funding period has ended, in fully de-identified form.

Authors’ contributions

DKK-drafted the manuscript. DKK, CM, MWH, SC, GHG, VVG, SCR, RLY, TEM have made substantial contributions to conception and design, and/or acquisition of data, and interpretation of data. MSL- has made substantial contributions to data analysis and interpretation of data. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication


Ethics approval and consent to participate

The study was approved by the University of Rochester Research Subject Review Board (approval number RSRB 00053321) and also by the IRBs of the remaining five study sites. The informed consent of all human subjects who participated in this investigation was obtained after the nature of the procedures had been explained fully. As per regional IRB requirements written informed consents were used in the Midwest, South Atlantic and Northeast regions of the network and verbal informed consents were used in South Central, Western and Southwestern regions of the network.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

Eastman Institute for Oral Health, University of Rochester, Rochester, USA
University of Alabama at Birmingham, Birmingham, USA
Private practice of general dentistry, Morristown, USA
University of Florida, Gainesville, USA
Health Partners, Minneapolis, USA
Private practice of periodontics, Olympia, USA
University of Texas Health Science Center at San Antonio, San Antonio, USA


  1. Canadian Advisory Board on Dentin Hypersensitivity. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. J Can Dent Assoc. 2003;69:221–6.Google Scholar
  2. Porto IC, Andrade AK, Montes MA. Diagnosis and treatment of dentinal hypersensitivity. J Oral Sci. 2009;51:323–32.View ArticlePubMedGoogle Scholar
  3. Amarasena N, Spencer J, Ou Y, Brennan D. Dentine hypersensitivity - Australian dentists’ perspective. Aust Dent J. 2010;55:181–7.View ArticlePubMedGoogle Scholar
  4. Amarasena N, Spencer J, Ou Y, Brennan D. Dentine hypersensitivity in a private practice subject population in Australia. J Oral Rehabil. 2011;38:52–60.View ArticlePubMedGoogle Scholar
  5. Chu CH, Lam A, Lo EC. Dentin hypersensitivity and its management. Gen Dent. 2011;59:115–22. quiz 123–4.PubMedGoogle Scholar
  6. Cummins D. Advances in the clinical management of dentin hypersensitivity: A review of recent evidence for the efficacy of dentifrices in providing instant and lasting relief. J Clin Dent. 2011;22:100–7.PubMedGoogle Scholar
  7. Parolia A, Kundabala M, Mohan M. Management of dentinal hypersensitivity: A review. J Calif Dent Assoc. 2011;39:167–79.PubMedGoogle Scholar
  8. Poulsen S, Errboe M, Lescay Mevil Y, Glenny AM. Potassium containing toothpastes for dentine hypersensitivity. Cochrane Database Syst Rev. 2006;3:CD001476.Google Scholar
  9. Liu HC, Lan WH, Hsieh CC. Prevalence and distribution of cervical dentin hypersensitivity in a population in Taipei, Taiwan. J Endod. 1998;24:45–7.View ArticlePubMedGoogle Scholar
  10. Gillam DG, Seo HS, Bulman JS, Newman HN. Perceptions of dentine hypersensitivity in a general practice population. J Oral Rehabil. 1999;26:710–4.View ArticlePubMedGoogle Scholar
  11. Cunha-Cruz J, Wataha JC, Heaton LJ, Rothen M, Sobieraj M, Scott J, Berg J. The prevalence of dentin hypersensitivity in general dental practices in the Northwest United States. J Am Dent Assoc. 2013;144:288–96.View ArticlePubMedPubMed CentralGoogle Scholar
  12. Dababneh RH, Khouri AT, Addy M. Dentine hypersensitivity - an enigma? A review of terminology, mechanisms, aetiology and management. Br Dent J. 1999;187:606–11. discussion 603.PubMedGoogle Scholar
  13. Rees JS, Addy M. A cross-sectional study of dentine hypersensitivity. J Clin Periodontol. 2002;29:997–1003.View ArticlePubMedGoogle Scholar
  14. Cunha-Cruz J, Wataha JC, Zhou L, Manning W, Trantow M, Bettendorf MM, Heaton LJ, Berg J. Treating dentin hypersensitivity: Therapeutic choices made by dentists of the northwest PRECEDENT network. J Am Dent Assoc. 2010;141:1097–105.View ArticlePubMedPubMed CentralGoogle Scholar
  15. Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. J Clin Periodontol. 1997;24:808–13.View ArticlePubMedGoogle Scholar
  16. Orchardson R, Gillam DG. Managing dentin hypersensitivity. J Am Dent Assoc. 2006;137:990–8. quiz 1028–9.View ArticlePubMedGoogle Scholar
  17. Veitz-Keenan A, Barna JA, Strober B, Matthews AG, Collie D, Vena D, Curro FA, Thompson VP. Treatments for hypersensitive noncarious cervical lesions: a Practitioners Engaged in Applied Research and Learning (PEARL) Network randomized clinical effectiveness study. J Am Dent Assoc. 2013;144:495–506.View ArticlePubMedPubMed CentralGoogle Scholar
  18. The National Dental Practice-Based Research Network, the nation’s network. Accessed 30 June 2016.
  19. Gilbert GH, Williams OD, Korelitz JJ, Fellows JL, Gordan VV, Makhija SK, Meyerowitz C, Oates TW, Rindal DB, Benjamin PL, Foy PL, National Dental PBRN Collaborative Group. Purpose, structure and function of the United States National Dental Practice-Based Research network. J Dent. 2013;41:1051–9.View ArticlePubMedGoogle Scholar
  20. Brannstrom A, Astrom A. The hydrodynamics of dentin and its possible relationship to dentinal pain. Int Dent J. 1972;22:219–27.PubMedGoogle Scholar
  21. Makhija SK, Gilbert GH, Rindal DB, Benjamin P, Richman JS, Pihlstrom DJ, Qvist V, DPBRN Collaborative Group. Practices participating in a dental PBRN have substantial and advantageous diversity even though as a group they have much in common with dentists at large. BMC Oral Health. 2009;9:26.View ArticlePubMedPubMed CentralGoogle Scholar
  22. Makhija SK, Gilbert GH, Rindal DB, Benjamin PL, Richman JS, Pilhstrom DJ, DPBRN Collaborative Group. Dentists in practice-based research networks have much in common with dentists at large: evidence from the Dental Practice-Based Research Network. Gen Dent. 2009;57:270–5.PubMedPubMed CentralGoogle Scholar
  23. Gordan VV, Garvan CV, Heft MW, Fellows JL, Qvist V, Rindal DB, Gilbert GH, DPBRN Collaborative Group. Restorative treatment thresholds for interproximal primary caries based on radiographic images: findings from the Dental Practice-Based Research Network. Gen Dent. 2009;57:654–63. quiz 64–6, 595, 680.PubMedPubMed CentralGoogle Scholar
  24. Gordan VV, Garvan CW, Richman JS, Fellows JL, Rindal DB, Qvist V, Heft MW, Williams OD, Gilbert GH, DPBRN Collaborative Group. How dentists diagnose and treat defective restorations: evidence from the dental practice-based research network. Oper Dent. 2009;34:664–73.View ArticlePubMedPubMed CentralGoogle Scholar
  25. Norton WE, Funkhouser E, Makhija SK, Gordan VV, Bader JD, Rindal DB, Philstrom DJ, Hilton TJ, Frantsve-Hawley J, Gilbert GH, NDPBRN Collaborative Group. Concordance between clinical practice and published evidence: findings from The National Dental Practice-Based Research Network. J Am Dent Assoc. 2014;145:22–31.View ArticlePubMedGoogle Scholar
  26. American Dental Association Survey Center. The 2010 Survey of Dental Practice. Chicago: American Dental Association; 2012.Google Scholar


© The Author(s). 2017