MicroRNA expression as a prognostic biomarker of tongue squamous cell carcinoma (TSCC): a systematic review and meta-analysis

Table 3 Evaluation of GRADE pro-GDT

Certainty assessment							№ of patients		Effect	Certainty	Importance
№ of studies	Study design	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations	Intervention	Control	Relative (95% CI)	Certainty	Importance
13	Observational studies	not serious	not serious	not serious	not serious	all plausible residual confounding would suggest spurious effect, while no effect was observed dose response gradient	495/891 (55.6%)	396/891 (44.4%)	HR 1.34 (1.25 to 1.44)	⨁⨁⨁⨁¹ High	CRITICAL

¹Certainty: ⨁⨁⨁⨁ High
The HR of OS-1.34 (1.25 to 1.44) indicated higher levels of different miRNAs expressions in TSCC patients, demonstrating great statistical significance in prognosis of TSCC patients

ISSN: 1472-6831