Skip to main content

Kikuchi-Fujimoto disease: a case report and the evaluation of diagnostic procedures



Kikuchi-Fujimoto disease, known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting and systemic disorder involving lymph nodes with unknown aetiology. First reported in Japan, there has been an increase in its incidence globally. Because of its non-specific clinical features, the disease can be easily mistaken for other forms of lymphadenitis with a high rate of misdiagnosis and mistreatment, posing a considerable challenge.

Case presentation

A case of young Chinese woman with fever and cervical lymphadenopathy is presented. Physical examinations and imaging techniques were used to rule out common forms of lymphadenitis (e.g. cat-scratch disease and tuberculous lymphadenitis). Laboratory tests were then conducted to exclude others such as systemic lupus erythematosus and non-Hodgkin lymphoma. After Kikuchi-Fujimoto disease was identified, the patient was managed with symptomatic treatments. Our case was compared with relevant cases in the literature. A diagnostic flow chart was proposed to facilitate the diagnosis and treatment.


With its shared clinical features, Kikuchi-Fujimoto disease can be mistaken for other forms of lymphadenitis. A combined use of medical imaging and laboratory tests is the effective way to avoid misdiagnosis.

Peer Review reports


Histiocytic necrotizing lymphadenitis (HNL) is a benign and self-limiting systemic disorder, involving lymph nodes with clinical manifestations of mild fever, superficial lymphadenopathy and rash among others. It is commonly known as Kikuchi-Fujimoto disease (KFD) as first reported in Japan by Kikuchi [1] and Fujimoto [2] in 1972. Due to its low incidence rate and non-specific clinical features, KFD has not been well understood. Although unidentified infectious agents and an autoimmune response have been considered as the prime causes, the KFD pathogenesis remains unclear [3]. Because of its shared clinical features, the disease can be easily mistaken for other forms of lymphadenitis with a misdiagnosis rate up to 40% [4]. Near half a century has passed, the difficulties remain in distinguishing KFD from other lymph node diseases and continue to pose significant risks to misdiagnosis and unnecessary treatment [5]. This is particularly so in the diagnosis and treatment of oral diseases as the posterior cervical chain is the most common location for KFD. Therefore, it become imperative to evaluate existing diagnostic procedures and to avoid misdiagnosis and mistreatment. This paper reports the case of a young Chinese woman with fever and painful cervical lymphadenopathy and presents a critical comparison with relevant cases in the literature. The paper also identifies and assesses practical steps for diagnosing and managing KFD.

Case presentation

A 23-year-old female patient had mild fever and multiple swellings in the left neck and felt pain upon touch. She was generally healthy and fit. When asked, the patient denied the following abnormalities: headache, insomnia, anorexia and weight loss. Her condition had been previously considered as “lymphadenitis” in a local clinic, however it failed to abate even after 2 months’ treatment with anti-inflammatory drugs.

On physical examination, the face of the patient was found generally symmetrical, and the mouth could open normally. Several swelling masses were observed in the left neck with the diameter being about 1.5 cm, and were soft and tender to palpation. No obvious lesions were found in the oral cavity, except the left and right third molars were impacted. Magnetic resonance imaging (MRI) scans revealed multiple swollen lymph nodes in both sides of the neck, but most noticeably in the left. An ultrasound of her neck confirmed lymph node enlargements. Thus, she was admitted to the hospital for further diagnosis.

With the patient’s consent, additional medical examinations and pathological analyses were carried out to determine the nature of the lesion. The results from chest X-ray filming, tuberculin test and nasopharyngeal biopsy were all negative, ruling out tuberculous lymphadenitis (TbL) and nasopharyngeal carcinoma. A cervical lymph node biopsy was conducted, revealing multifocal coagulative necrosis in the paracortical area, plentiful nuclear debris and large mononuclear cells in the periphery, as shown in Fig. 1. Immunohistochemical analysis showed the histocytes in the biopsy were both MPO (myeloperoxidase)-positive and CD68-positive, further pointing to histiocytic necrotizing lymphadenitis. Thus, the patient was kept at the hematology department in our hospital for further monitoring. During her stay in the hospital, she was reviewed daily and managed with symptomatic treatments to reduce her temperature and swellings. The patient was finally discharged in a month after a full recovery. There has been no sign of recurrence at 18-month follow-up.

Fig. 1

a Photomicrograph (magnified × 40) of paracortical area of the lymph node from the patient’s left neck; b an enlarged part, showing the characteristic features of HNL with multifocal coagulative necrosis: plentiful nuclear debris (arrowed in Blue), large mononuclear cells in the periphery (arrowed in RED), and no visible neutrophil in the necrotic area

Discussion and conclusion

Kikuchi-Fujimoto disease (KFD) was first reported in 1972, however, its cause remains unknown. It is generally accepted that KFD is a non-neoplastic lymph node enlargement disease, a type of lymphoid reactive hyperplasia [3]. KFD was found mostly in young people [6] and with a very low recurrence rate (about 3%) [7]. Previously KFD was thought to be prevalent in women, but some studies indicate the disease could affect both sexes [8]. In the past, the disease was mostly noted in East Asia (e.g. Japan). However there has been a gradual increase in publication of KFD cases beyond East Asia.

To understand the disease and improve its diagnosis, it is crucial to have a comparative review of various aspects relating to the disease. We surveyed the literature on KFD and compared our case with some of those reported recently (see Table 1) on the key aspects, including sex, age, ethnic origin, symptom and treatment.

Table 1 A comparison with some cases reported in the literature

Table 1 clearly shows that these KFD cases have been reported from various continents, including other Asian countries (Turkey [9], Bangladesh [11] and Sri Lankan [14]), Europe (UK [10] and France [15]), Africa (Senegal [12]) and the USA [13], although the very first case out of East Asia was documented before 1982 [16]. Together with the fact that KFD has non-specific clinical features and that it can be easily confused with other diseases [13], the spread of KFD into other continents and other ethnic groups will certainly urge medical professionals to better understand and treat the disease.

To diagnose the disease promptly and accurately, it is essential to conduct an analysis of any abnormalities in the patient caused by the disease. The two of the most relevant aspects are clinical manifestations and pathological features.

Clinical manifestations of KFD are primarily fever and lymphadenopathy. The common symptoms can be summarized as follows: (a) fever with a body temperature fluctuated at 38 ~ 41 °C (some patients with mild chills), lasting about 4 to 6 weeks; (b) superficial lymph nodes, mainly in the neck, with a diameter of 0.5 to 3 cm; (c) congestive maculopapular rash, commonly in the trunk, limbs and cheeks with the skin being mildly edematous and itchy; (d) mild hepatosplenomegaly with around 0.5 to 2 cm enlargement of the liver. As these symptoms are not limited to this disease, KFD could be mistaken for others, e.g. malignant lymphoma. Thus more specific analyses must be carried out to avoid misdiagnosis and mistreatment.

Pathological analysis of the lymph node biopsy is frequently performed. The diseased tissues generally show extensive coagulative necrosis and histiocytosis in the cortical and paracortical regions of the lymph nodes (see Fig. 1). The histological features, such as clusters of plasma-like mononuclear cells with scattered nuclear debris and crescent-shaped tissue cells, are indistinguishable from those of lymphoma. So additional diagnostic procedures are required. For example, as immunohistochemical staining can reveal the presence of MPO-positive and CD68-positive cells [7], such a pathological tool would be useful for both diagnostic and differential diagnosis.

Medical imaging

In comparison with pathological analysis such as biopsy, medical imaging is much quicker and less invasive. Magnetic resonance image and ultrasound scan have been used in our case to confirm lymph node enlargement. Other imaging technologies such as positron emission tomography/computed tomography have also been exploited [17], however they can provide useful evidence, but not a definitive diagnosis.

Diagnosis and differential diagnosis

As discussed above, the main symptoms for KFD are un-explained fever and lymphadenopathy. Thus, the following observations are particularly worth noting: (a) long-term fever even after antibiotic treatment; (b) large superficial lymph nodes, but little or no sign of hepatosplenomegaly and (c) negative results from blood test and bone marrow culture. Due to non-specific clinical manifestations, the disease can be misdiagnosed as other disorders, such as tumors (e.g. Non-Hodgkin’s lymphoma) or infectious diseases (e.g. TbL or cat scratch disease [18]) or concurrent systemic lupus erythematosus (SLE). A recent study [19] reported 12% KFD patients had a history of SLE. A comparison of KFD with some related disorders is shown in Table 2, listing different characteristics for each of the disorders.

Table 2 A comparison of KFD with some lymphadenitis diseases

HNL Histiocytic necrotizing lymphadenitis, NHL Non-Hodgkin’s Lymphoma, TbL Tuberculous lymphadenitis, CSD Cat-scratch disease, SLE Systemic lupus erythematosus

Table 2 shows that fever exists in all these listed disorders, so cannot be used to distinguish KFD from others. However, detailed temperature charts may be helpful. For instance, KFD patients, generally, show an irregular fever pattern while patients with non-Hodgkin’s lymphoma (NHL) have relapsing fever and those with TbL experience intermittent fever. Although pain is felt in some of the listed disorders, but not always complained of by the patients. The sensation of pain is rather subjective and thus cannot be used for differential diagnosis. The self-limiting factor is well noteworthy during the management of the symptoms, however, it is no practical use in terms of diagnosis.

Although histopathological features are not always the same among all these disorders, they do display certain characteristics useful for diagnosis. KFD and NHL share certain histopathological features, such as proliferation of immunoblasts and plasmacytoid dendritic cells at the edges of necrotic foci [20]. Immuno-staining would be helpful as the positivity of histiocytes for myeloperoxidase can be used to exclude T-cell lymphomas and can offer useful clues regarding infectious agents. For instance, the positivity of PPD test can certainly consolidate the diagnosis of tuberculosis while the finding of Bartonella henselae by Warthin–Starry stain would almost certainly confirm the case for CSD (as illustrated in Fig. 2). As to systemic lupus erythematosus (SLE) lymphadenopathy which is the hardest one to differentiate from KFD, the detection of hematoxylin bodies should add further support to the diagnosis of SLE over KFD.

Fig. 2

A flow chart for identifying KFD (Kikuchi-Fujimoto Disease) from other forms of cervical lymphadenitis. WS Stain: Warthin-Starry stain; PPD test: Purified protein derivative test; ANA: Anti-nuclear antibody; MDT-FC: Molecular diagnostic test and flow cytometry; MPO/CD68: myeloperoxidase/cluster of differentiation 68 protein. CSD: Cat-scratch disease; TbL: Tuberculous lymphadenitis; SLE: Systemic lupus erythematosus; NHL: Non-Hodgkin’s Lymphoma. KFD: Kikuchi-Fujimoto disease

Clearly, the diagnosis of KFD can be difficult and its differential diagnosis is more demanding. To aid medical practitioners, in particular, non-specialists to identify this rare disorder, a diagnostic flow chat is proposed in Fig. 2. Once a cervical lymphadenopathy is presented, appropriate medical assessments should be carried out. Physical examinations and imaging techniques can be used to rule out certain forms of lymphadenitis (e.g. CSD and TbL). With further laboratory tests, after excluding serious lymph node diseases such as SLE and NHL, KFD can be confirmed, treated and managed.

Treatment and management

Clinically, patients with unexplained fever should be carefully examined and closely monitored regarding any change with lymph nodes. If no improvement is observed in a week or so after the treatment with antibiotics, medical professionals should consider the possibility of KFD by conducting a lymph node biopsy to determine pathological features. Once KFD is confirmed and malignant lymphoma or other lymphatic diseases (such as TbL or CSD) are ruled out, appropriate steps are taken to facilitate the relief of the symptoms.

KFD is a subacute disease, mostly lasting 1 to 3 months, but some persisting for up to 1 year [8]. There is no universally agreed treatment plan as each case could be somehow different. The primary treatment of KFD is to manage the disease by supporting the patient mentally and physically to speed-up the relief of the symptoms. Table 1 lists some successful treatments to relieve the KFD symptoms. Antibiotics are not effective, however, their use in this case [13] is to avoid potential bacterial infections. The use of hormone-related drugs can relieve the symptoms and shorten the course of the disease. Prednisone was used as an effective treatment for pregnant women [9]. Generally, KFD is a benign and self-limiting disorder, so a short inpatient stay with symptomatic treatment (as in our case) generally suffice. However, for patients with significant systemic symptoms (e.g. multiple organ systems failure or immune system dysfunction), appropriate drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), hormones and immunosuppressants should be seriously considered to manage the symptoms while further specific diagnosis are to be carried out.

In summary, Kikuchi-Fujimoto disease is a rare disorder found mostly in young women of oriental origin with a slow spread to other ethnicities. Although benign and self-limiting in most cases, it can confuse medical professionals with other life-threatening diseases. Early and reliable diagnosis of the disease using imaging technologies and laboratory tests and appropriate management of the symptoms are uppermost to avoid misdiagnosis and mistreatment. The diagnostic flow chart illustrated in the paper should be helpful to medical professionals, particularly to non-specialists including oral health practitioners.

Availability of data and materials

The data used during the study are available from the corresponding author on reasonable request.



Cat-scratch disease


Histiocytic necrotizing lymphadenitis


Kikuchi-Fujimoto disease


Non-Hodgkin’s lymphoma


Systemic lupus erythematosus


Tuberculous lymphadenitis


  1. 1.

    Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia. Nippon Ketsueki Gakkai Zasshi. 1972;35:378–80.

    Google Scholar 

  2. 2.

    Fujimoto Y, Kozima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis. A new clinicopathological agent. Naika. 1972;20:920–7.

    Google Scholar 

  3. 3.

    Perry AM, Choi SM. Kikuchi-Fujimoto disease: A review. Arch Pathol Lab Med. 2018;142:1341–6.

    Article  Google Scholar 

  4. 4.

    Ramirez AL, Johnson J, Murr AH. Kikuchi-Fujimoto’s disease: an easily misdiagnosed clinical entity. Otolaryngol Head Neck Surg. 2001;125:651–3.

    Article  Google Scholar 

  5. 5.

    Lahma J, Arkoubi Z, Hejjouji R, Nitassi S, El Ayoubi A, Bencheikh R, et al. About a rare disease misdiagnosed as malignant lymphoma or tuberculosis: Kikuchi-Fujimoto’s disease. Pan Afr Med J. 2018;31:1–5.

    Google Scholar 

  6. 6.

    Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 2004;122:141–52.

    Article  Google Scholar 

  7. 7.

    Bogusz AM, Bhargava P. Recurrent histiocytic necrotizing lymphadenitis with a long latency in a patient with autoimmunity: a case report and review of literature. Int J Surg Pathol. 2013;21:287–96.

    Article  Google Scholar 

  8. 8.

    Lin H-C, Su C-Y, Huang C-C, Hwang C-F, Chien C-Y. Kikuchi’s disease: a review and analysis of 61 cases. Otolaryngol Head Neck Surg. 2003;128:650–3.

    Article  Google Scholar 

  9. 9.

    Altuntas F, Sari I, Canoz O, Yildiz O, Eser B, Cetin M, et al. Kikuchi-Fujimoto disease: a rare but important cause of fever and lymphadenopathy in pregnant women. Am J Hematol. 2006;81:118–20.

    Article  Google Scholar 

  10. 10.

    Kharoubi S. Kikuchi Fujimoto, one case report and review of the literature. Rev Laryngol Otol Rhinol (Bord). 2008;136:125–8.

    Google Scholar 

  11. 11.

    Md. Mamun Ali Biswas RP. Kikuchi’s Disease in a Young Female—a Case Report. J Gen Pract. 2013;01:1–2.

    Article  Google Scholar 

  12. 12.

    Lame C-A, Loum B, Fall A-K, Cucherousset J, Ndiaye A-R. Kikuchi-Fujimoto disease, a rare cause of lymphadenopathy in Africa. Description of the first case in Senegal and review of the literature. Eur Ann Otorhinolaryngol Head Neck Dis. 2017;134:347–9.

    Article  Google Scholar 

  13. 13.

    Humphreys S, Oikonomou KG, Ward N, Aye M. Kikuchi disease: the great Masquerador - a case report and review of the literature. Med Case Reports. 2018;04:1–4.

    Article  Google Scholar 

  14. 14.

    Dalugama C, Gawarammana IB. Fever with lymphadenopathy - Kikuchi Fujimoto disease, a great masquerader: a case report. J Med Case Rep. 2017;11:1–4.

    Article  Google Scholar 

  15. 15.

    Escudier A, Courbage S, Meignin V, Abbou S, Sauvion S, Houlier M, et al. Kikuchi-Fujimoto disease mimicking malignant lymphoma in adolescents. Arch Pediatr. 2017;24:471–5.

    Article  Google Scholar 

  16. 16.

    Pileri S, Kikuchi M, Helbron D, Lennert K. Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch A Pathol Anat Histol. 1982;395:257–71.

    Article  Google Scholar 

  17. 17.

    Erhamamci S, Reyhan M, Kocer NE. Kikuchi-Fujimoto disease as a rare cause of benign lymphadenopathy and 18F-FDG PET/CT findings. Hell J Nucl Med. 2014;17:41–4.

    PubMed  Google Scholar 

  18. 18.

    Shin OR, Kim YR. Ban T hyun, Lim T, Han TH, Kim SY, et al. a case report of seronegative cat scratch disease, emphasizing the histopathologic point of view. Diagn Pathol. 2014;9:14–7.

    Article  Google Scholar 

  19. 19.

    Dumas G, Prendki V, Haroche J, Amoura Z, Cacoub P, Galicier L, et al. Kikuchi-fujimoto disease: Retrospective study of 91 cases and review of the literature. Med (United States). 2014;93:372–82.

    Google Scholar 

  20. 20.

    Menasce LP, Banerjee SS, Edmondson D, Harris M. Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): continuing diagnostic difficulties. Histopathology. 1998;33:248–54.

    Article  Google Scholar 

Download references


The authors would like to thank Prof. Jianqi Huang for his invaluable guidance on the project.


Not applicable.

Author information




SX was responsible for the literature search and drafted the manuscript, which was checked and revised by WS and JL. All authors reviewed and approved the final manuscript.

Corresponding author

Correspondence to Shenjie Xu.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Written informed consent for the publication of potentially identifying information was obtained from the patient.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Xu, S., Sun, W. & Liu, J. Kikuchi-Fujimoto disease: a case report and the evaluation of diagnostic procedures. BMC Oral Health 19, 223 (2019).

Download citation


  • Kikuchi-Fujimoto disease
  • Histiocytic necrotizing lymphadenitis
  • Diagnosis
  • Rare disease