Skip to main content

Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review

Abstract

Background

Erosion is one of the most common and basic lesions of oral mucosal diseases. Long-term refractory oral erosions, induced by autoimmune blistering diseases, infectious diseases, malignant diseases, and some rare conditions, may substantially reduce the quality of life of patients or even constitute a life-threatening condition, resulting in a clinical dilemma regarding the accurate diagnosis and precise management of these diseases. As a special type of malignant lymphoma, most lesions of follicular lymphoma (FL) in the oral mucosa present as masses or swelling of the oral mucosa, while emerging novel presentations lead to intractable diagnoses. Hence, diagnostic algorithms for such diseases are clinically required. 

Case presentation

A 55-year-old female patient presented to the clinic with long-lasting oral mucosal erosions and proliferative lesions. Blood tests, pathological examinations of oral lesions including haematoxylin–eosin (HE) staining, and direct immunofluorescence precluded all of the potential diagnoses described previously. Unexpectedly, positron emission tomography/computed tomography (PET/CT) and abdominal CT of the patient revealed a dense mass in the retroperitoneal area, and the final diagnosis of the retroperitoneal mass was FL. After three courses of chemotherapy conducted by the haematologist, the erosion and proliferative lesions in the patient's oral mucosa had significantly improved. HE and immunohistochemical staining results of intraoral lesions also confirmed it as oral FL. The successful diagnosis of FL in this case is of great clinical significance, as the oral and abdominal FL were treated in a timely manner to avoid unfavourable outcomes.

Conclusions

To the best of our knowledge, this is the first case of FL that exhibited widespread erosions interspersed with proliferative lesions. Clinicians should be aware of oral FL or seek systemic factors in the presence of similar refractory oral erosions when treatment is non-responsive and the diagnosis is intractable.

Peer Review reports

Background

Oral mucosal diseases are characterised by their high incidence and wide extent of involvement. For example, the prevalence of recurrent aphthous ulcer (RAU) ranges from 5 to 25% [1], and the associated Behcet’s disease might involve other body sites besides the oral mucosa [2]; thus, oral mucosal lesions may serve as an indicator of systemic diseases. Erosions or ulcers are common manifestations and basic lesions of oral mucosal diseases, with erosions histologically presenting as partial defects of the mucosal epithelium and ulcers as defects of the entire epithelial layer. Oral mucosal diseases such as oral lymphoma may manifest as erosions and ulcers [3]. Long-lasting erosions or ulcers may lead to severe distress and a significant decrease in quality of life, and in some cases, may even be life-threatening. For instance, long-term RAU or erosion poses a substantial threat to the quality of life of patients by causing difficulties with daily food intake or weight loss due to severe pain, repeated seeking of medical advice, and compelled consumption of various types of medicine including steroids, immunosuppressants, and even biologics such as intravenous immunoglobulins, thereby inducing serious physical and psychological pressure [4,5,6]. In addition, recalcitrant and complicated oral ulceration or erosions might represent a non-specific sign of malignancies with poor prognosis; for example, a one-month large palatal ulceration resistant to routine treatment was ultimately diagnosed as a presentation of NK/T-cell lymphoma, which has aggressive behavior and a poor outcome [7].

Apart from these common aetiologies contributing to oral erosions, such as oral lichen planus (OLP), a small proportion of persistent oral erosions may be oral manifestations of systemic diseases or other factors. In recent years, oral medicine clinicians and pathologists have faced emerging challenges owing to refractory and complicated oral erosions. First, regular inquiry of medical history and oral examination are insufficient to obtain the actual diagnosis of some challenging oral erosions. Second, the definite diagnosis of some non-specific oral signs may require biopsy, which must include normal-appearing tissue and have adequate depth in addition to diseased tissue, after which haematoxylin–eosin (HE), direct immunofluorescence (DIF), and immunohistochemistry (IHC) might be required to reveal the actual disease. Thus, the accuracy of the whole process is largely dependent on the experience of dental clinicians and oral pathologists. Third, besides the detection of biopsied lesions, some adjuvant examinations are recommended to identify systemic factors responsible for the oral erosions, encompassing computed tomography (CT), ultrasonography, blood testing, whole exome sequencing, and so forth. Finally, for refractory oral erosions that cannot be diagnosed through the aforementioned measures, multi-disciplinary team consultation, diagnostic treatment, and further biopsy may be required to achieve an adequate diagnosis [3, 7,8,9].

A large number of oral mucosal diseases can be characterised by oral mucosal erosion, including oral allergic diseases [10], oral infectious diseases such as tuberculosis (TB) [3], pemphigus/pemphigoid [11], paraneoplastic autoimmune multiorgan syndrome (PAMS) [12], oral potentially-malignant disorders (OPMD) represented by OLP [13], oral malignancies including oral squamous cell carcinoma (OSCC) [14], and genetic diseases such as dyskeratosis congenita [8] (Table 1). These diseases may be distinguished from each other based on various features, such as the clinical duration and medical history, and by engaging diagnostic approaches, including examination of biopsied tissue and systemic adjuvant examination.

Table 1 Differential diagnoses of long-lasting oral erosive lesions based on existing literatures

We recently reported a woman with multiple refractory and scattered oral erosions accompanied by several proliferative and nodule-like lesions who had failed to respond to conventional treatment regimens (low-dose oral prednisone with dexamethasone mouthwash) and was finally diagnosed with oral manifestations associated with abdominal follicular lymphoma (FL) after a multidisciplinary consultation. FL is a lymphoid tissue systemic malignancy that exhibits germinal center B B-cell differentiation, and a small proportion of patients with FL might have poor outcomes [31]. Non-Hodgkin’s lymphomas (NHL) is a special type of lymphoma which frequently involves the head and neck region, and about 20–25% of NHL are diagnosed as FL [31]. Orally, FL typically presents as masses or swelling of the oral mucosa, which is a non-specific presentation among oral mucosal diseases, thus triggering difficulties and complexities in diagnosis [32]. The final diagnosis of this case was made through a combination of the clinical manifestations, thorough medical history enquiry, radiographic examination, multi-disciplinary cooperation, and pathological findings, exemplifying the diagnostic logistics of such complicated cases. To the best of our knowledge, this is the first case report of secondary FL presenting as widespread erosive and proliferative lesions in the oral mucosa, which might serve as a significant reminder in our future clinical practice.

Case presentation

A 55-year-old woman presented to our oral medicine clinic with refractory and recurrent erosions of the oral mucosa persisting for more than 2 years. Her condition had gradually worsened over the past 6 months, with almost no healing period for the oral erosions. The patient complained of severe and obvious pain after eating irritating food. Upon clinical inspection, a region of erosion with a surface area of 40 mm × 20 mm was observed on the dorsum of the tongue, interspersed with several proliferative or nodule-like lesions with diameters ranging from 4 to 6 mm. The height of nodules was about 5 mm above the mucosal level, which was palpated and considered to be of moderate texture (Fig. 1A). Linear or reticular white striae accompanied by erosions and hyperaemia were observed on the right angle of the mouth, inner mucosa of both lips, bilateral tongue margins, and the lower part of the buccal mucosa (Fig. 1B, C, and D). The whole gingiva was hyperaemic and eroded along with shallow vesicles. The Nikolsky sign was positive, and the tongue was flexible and soft, which is the same for typical oral mucosa. Overall, periodontal hygiene was poor. In addition, enlarged lymph nodes were palpated in both mandibular regions, and the lymph nodes in the left mandibular region were relatively fixed without pain upon touching. A history of hypertension and a surgery for total hysterectomy were recorded upon medical history enquiry, and no drug allergy was revealed.

Fig. 1
figure 1

Oral mucosal manifestations of the patient. Widespread erosive lesions on the dorsum of tongue, interspersed with several mucosal proliferative or nodule-like lesions (A). Linear or reticular white striae with erosions and hyperemia could be observed on bilateral tongue margins (B), right angle of the mouth (C), and the lower part of right and left buccal mucosa (C and D). Black arrows: proliferative lesions with erosive surface. Blue arrows: reticular white striae. White arrows: erosions. All images were captured at the resolution of 300 dpi

In terms of potential diagnosis, given the atypically widespread and refractory erosions on the oral mucosa, autoimmune blistering diseases, special infections such as human immunodeficiency virus (HIV) and syphilis, OLP, or malignant lesions, came up as the initial impression based on our clinical experience. Next, several examinations were suggested to achieve the diagnosis, including routine blood tests, glucose tests, biochemical tests, bullous disease antibodies against Dsg1, Dsg3, and Bp180, and testing for HIV and syphilis; negative findings were indicated in these tests. Furthermore, chest computed tomography (CT), abdominal ultrasonography, and biopsy of the inner mucosal lesions of the right upper lip were performed.

Meanwhile, the patient required medication during the process of receiving further tests. This course included 30 mg of prednisone per day for one week, 50 mg of thalidomide per day for 10 days and 0.1 mg/mL dexamethasone mouthwash; however, no significant recovery of the oral erosions and proliferative lesions was observed at the revisit, which emphasized the complexity of the disease and the potential systemic nature. For the biopsy, the inner-side mucosa of the right upper lip was selected because of the co-existence of erosion and white striae, which was not visibly present on the tongue. After HE staining, nodular aggregation of lymphocytes and plasma cells was observed in the subepithelial connective tissue and around the blood vessels under a microscope (Fig. 2A). The DIF test for diagnosing bullous disease showed negative results for IgA, IgG, IgM, and C3. In addition, chest CT was negative. However, positron emission tomography/computed tomography (PET/CT) of the patient, which was further suggested, provided a surprising clue. Specifically, the inspection showed increased metabolism in the salivary glands, an enlarged liver and spleen, and multiple hypermetabolic lymph nodes throughout the body. In addition, significantly thickened soft tissue was observed in the retroperitoneal area on abdominal ultrasonography, which encapsulated the abdominal aorta and mesenteric vessels, and an abundant blood supply was observed. All the above signs indicate haematologic disease in the retroperitoneal area. After visiting the haematology department, pathological examination of the patient's retroperitoneal mass revealed FL grade I-II and stage IV, and the patient was categorised into the intermediate-risk group, with the FL international prognostic index (FLIPI) score defined as 2. In order to investigate whether the intraoral lesion was related to lymphoma in the abdomen, the tissue sample from the upper lip mucosa was further stained by IHC, which showed follicular-like structures presenting as CD20 ( +) and B-cell lymphoma 2 (BCL-2) ( +), while the staining for CD10, CD5, and CD3 was negative, and CD21, CD23, and follicular dendritic cells (FDC) were positive (Fig. 2B-D). Thus, in light of the masses in the retroperitoneal area and HE together with IHC results of the oral tissue, the diagnosis of oral involvement by FL was finally made upon multidisciplinary discussion.

Fig. 2
figure 2

Pathological examination of the oral lesion. A HE staining of the right upper lip mucosa showed nodular aggregation of lymphocytes and plasma cells in the subepithelial connective tissue and around the blood vessels. B-D IHC result of the right upper lip mucosa showed follicular-like structures presenting as CD20 ( +), BCL-2 ( +), CD21 ( +), respectively. Black arrow: nodular aggregation of lymphocytes. All stained sections were imaged using Aperio Versa (Leica, Germany) at 100 × and 200 × magnification, and the images of stained slides were acquired at the resolution of 300 dpi. Abbreviations: HE: hematoxylin–eosin; IHC: immunohistochemistry; BCL-2: B-cell lymphoma-2

The patient was then referred to haematology department for further treatment of FL, and 0.1 mg/mL dexamethasone together with 2% sodium bicarbonate mouthwash was recommended for topical treatment of oral lesions. After meticulous evaluation by a haematologist, the patient was treated with a rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen as follows: rituximab 500 mg D0, vinorelbine 30 mg D1, pirarubicin 60 mg D1, cyclophosphamide 1 g D1, hydrogenated prednisone 40 mg D1, D5. Over three courses of chemotherapy, the intraoral lesions improved significantly, the nodule-like lesions on the dorsum of the tongue disappeared, and the oral erosions were also controlled. The patient was then recommended routine visits to the haematology clinic every 2 months, and no further recurrence of oral lesions was observed in the follow-up visits until May 2022 (the third year after the onset of disease) (Fig. 3).

Fig. 3
figure 3

Recent follow-up imaging of the patient’s dorsum of tongue shows significant remission of the erosions and proliferative lesions after undergoing standardized chemotherapy against the follicular lymphoma. The image was captured at the resolution of 300 dpi

Discussion and conclusions

Here, we report a case of long-lasting refractory erosions in the oral mucosa for more than 2 years, which was finally diagnosed as oral manifestations of FL. Although the diagnosis process had consumed tremendous time and effort, the patient received appropriate treatment.

As shown in Table 1, there are several common diseases in which long-term oral erosion might present as the main manifestation, including autoimmune blistering diseases such as pemphigus vulgaris and pemphigoid, acquired immune deficiency syndrome (AIDS), syphilis, OPMD such as OLP, and oral malignant lesions (Table 1). Autoimmune blistering diseases may present with bullous lesions in the oral mucosa, or manifest as large areas of irregular erosive and hyperaemic lesions following the rupture of the bulla [11, 15], the diagnosis of which is mainly dependent on HE and DIF results of lesions [16, 17]. To diagnose AIDS and syphilis, which may also present with non-specific oral erosions, blood tests for specific antibodies may be recommended [19, 21]. In terms of OPMD, the intraoral manifestations of OLP generally include symmetrical white striae interspersed with irregular erosions [23, 24]. Discoid lupus erythematosus may be characterised by erosions surrounded by radial white striae, commonly seen in the lower lip [26]. Oral leucoplakia, or oral erythroplakia, is primarily characterised by white or scarlet patches accompanied by persistent erosions, and histological examination is essential for the ultimate diagnosis of OPMD [25, 33]. In addition, oral malignant lesions, predominantly represented by OSCC, tend to present as localized ulcers with a firm texture on their margins upon palpation. The tongue is the most frequently involved site for these ulcers [14]. Based on the features of the pathological examination and blood test results, all of the above diagnoses could be excluded for this patient.

Additionally, some relatively rare diseases may mimic the form of multiple intraoral persistent erosions, including paraneoplastic pemphigus (PNP) or PAMS [9], oral infections such as TB [22], haematopoietic and lymphoid neoplasms including Langerhans cell histiocytosis (LCH) [29], genetic diseases represented by dyskeratosis congenita [8], and pyostomatitis vegetans (PSV) [34]. PNP, also known as PAMS, is a lethal autoimmune disease associated with tumours such as thymoma. Because multiple organs may be involved, the term PAMS has been proposed to fully reflect the clinical manifestations and immunopathological features of the disease [9, 18, 35]. Clinically, PAMS manifests as erosions or bulla of the skin, and mucous membranes might be demonstrated [12]. In line with pemphigus, the diagnosis of PAMS also relies on HE and DIF [12, 36]. Therefore, a diagnosis of PAMS was excluded. Oral TB can also manifest as recalcitrant ulcers or erosions with irregular margins, for which typical Langerhans giant cells viewed under the microscope and the presence of TB DNA upon quantitative polymerase chain reaction (qPCR) are the dominant features [3, 22]; therefore, oral TB was eliminated from this case. Haematopoietic and lymphoid malignancies containing LCH might also be characterised by erosions [30]. HE, IHC, and blood tests are important clues for diagnosis. Additionally, genetic diseases such as dyskeratosis congenita can also show similar features [8], for which whole-exome sequencing is an indispensable diagnostic marker, in addition to biopsy of the lesion. Moreover, PSV, as a relatively specific sign of inflammatory bowel disease (IBD), can also present as proliferative pustular lesions and subsequent erosions in the oral mucosa [27], the diagnosis of which largely depends on clinical presentation, peripheral eosinophilia, and histological characteristics [28]. Notably, proliferative lesions displaying nodule-like or granular-like forms might be observed in the erosive lesions of oral diseases such as oral TB [22], syphilis [20, 37], pemphigus vegetans [38], lymphoma [39], OSCC [40], and PSV [41]; therefore, these diseases cannot be ignored as potential diagnoses when oral erosions are accompanied by proliferative lesions.

Based on the features of the aforementioned diseases and the systemic findings, the oral presentations of the patient and differential diagnosis were made, and the ultimate conclusion was oral manifestations of FL, one of the most frequent NHL. In Western countries, FL accounts for approximately 5% of all haematologic neoplasms and about 20–25% of all newly diagnosed NHL [31]. Up to 40% of NHL were identified at extranodal sites, of which the head and neck region is the second most involved site of extra-nodal lymphomas [42]. However, primary lymphomas of the oral cavity are very rare, accounting for only 3% of all lymphomas in the general population [43]. According to a study by Barone S et al., the most commonly involved sites are in the soft tissues of oral cavity, with an incidence rate presenting as 38.4%, 19.2%, and 11.5% for buccal mucosa, tongue and gingiva [44]. As for the clinical appearance, lymphoma occurring in the gingiva, buccal mucosa, and palate usually manifests as ulceration (Table 2) [39, 45,46,47,48,49,50,51,52,53,54,55,56], while that of FL has been discussed above, and masses or nodular lesions may be observed or palpated under the mucosa of the palate, buccal, and tongue [39, 45, 50, 51, 57,58,59,60]. Swelling of the lip, palate, gingiva, or buccal mucosa may serve as alternative oral signs of lymphoma [61,62,63,64]. Meanwhile, accompanying symptoms such as enlargement of multiple superficial lymph nodes in the head and neck region and mucosal necrosis have also been reported [47]. To the best of our knowledge, this is the first report of oral manifestations of FL exhibiting widespread erosion interspersed with proliferative lesions in the oral mucosa. However, it seems difficult to judge whether the initial site of manifestation of the FL was in the oral mucosa or in the retroperitoneal area, based on the medical history of this case.

Table 2 Summarized oral manifestations of lymphomas reported in previous literatures

The pathogenesis of FL that leads to oral mucosal erosion and proliferative lesions is unknown. However, this process may be associated with the tumour immune microenvironment. In FL, the tumour microenvironment is one of the main contributors to tumour cell survival and proliferation. These important components of the microenvironment, such as follicular germinal centers, helper T cells, macrophages, and FDCs, play crucial roles in the formation of oral FL lesions [65]. In FL with poor prognosis, the functional genes of FDC were relatively overexpressed, and the helper T cells were functionally active, producing various cytokines such as IL-2, IL-12, and IFN-γ [66]. Thus, the abnormal activity of these immune cells and overexpression of cytokines may be responsible for the onset of oral mucosal lesions.

Based on the diagnostic process of this particular case and the logistics of differential diagnosis, we have summarised a flowchart of the diagnostic algorithm for patients with refractory oral erosions (Fig. 4), thus ensuring a fast and accurate diagnosis for patients presenting in oral medicine clinics.

Fig. 4
figure 4

Diagnostic algorithms for diseases characterized by refractory erosion of the oral mucosa proposed by the authors of this work. Abbreviations: HIV: human immunodeficiency virus; HE: hematoxylin–eosin; OPMD: oral potentially malignant disorders; OLP: oral lichen planus; OLK: oral leukoplakia; OE: oral erythroplakia; DLE: discoid lupus erythematosus; DIF: direct immunofluorescence; CT: computed tomography; PAMS: paraneoplastic autoimmune multiorgan syndrome; PNP: paraneoplastic pemphigus; PSV: pyostomatitis vegetans; OSCC: oral squamous cell carcinoma; qPCR: quantitative polymerase chain reaction; TB: tuberculosis; LCH: Langerhans cell histiocytosis; IHC: immunohistochemistry; FL: follicular lymphoma

The clinical manifestations of intraoral FL are mostly masses or swelling of the oral mucosa [32]. This case serves as the initial report of FL presenting as scattered erosions and proliferative lesions in the oral mucosa. Upon receiving patients with widespread and refractory oral mucosal erosions, the common diagnosis of OLP, autoimmune bullous disease, HIV, and syphilis should be initially considered, and PAMS, oral TB, LCH, genetic diseases, and PSV should also be evaluated. If all these are excluded, accompanied by the ineffectiveness of the conventional treatment, clinicians should be aware of systemic malignancies such as FL. 

Availability of data and materials

Not applicable.

Abbreviations

AIDS:

Acquired immune deficiency syndrome

BCL-2:

B-cell lymphoma 2

CT:

Computed tomography

DIF:

Direct immunofluorescence

DLE:

Discoid lupus erythematosus

FDC:

Follicular dendritic cell

FL:

Follicular lymphoma

FLIPI:

Follicular lymphoma international prognostic index

HE:

Hematoxylin–eosin

HIV:

Human immunodeficiency virus

IBD:

Inflammatory bowel disease

IHC:

Immunohistochemistry

LCH:

Langerhans cell histiocytosis

NHL:

Non-Hodgkin’s lymphomas

OE:

Oral erythroplakia

OLK:

Oral leukoplakia

OLP:

Oral lichen planus

OPMD:

Oral potentially malignant disorders

OSCC:

Oral squamous cell carcinoma

PAMS:

Paraneoplastic autoimmune multiorgan syndrome

PET/CT:

Positron emission tomography/computed tomography

PNP:

Paraneoplastic pemphigus

PSV:

Pyostomatitis vegetans

qPCR:

Quantitative polymerase chain reaction

RAU:

Recurrent aphthous ulcer

R-CHOP:

Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone

TB:

Tuberculosis

References

  1. Slebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review. Arch Immunol Ther Exp (Warsz). 2014;62(3):205–15.

    Article  Google Scholar 

  2. Dzhus MB, Karasevska TA, Tsaralunga VM, Yurchenko AV, Ivashkivsky OI. Behçet’s disease with intestinal involvement: case-based review. Rheumatol Int. 2022;42(9):1653–60.

    Article  PubMed  Google Scholar 

  3. Zeng X, Jin X, Zhong L, Zhou G, Zhong M, Wang W, Fan Y, Liu Q, Qi X, Guan X, et al. Difficult and complicated oral ulceration: an expert consensus guideline for diagnosis. Int J Oral Sci. 2022;14(1):28.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Ryu HJ, Seo MR, Choi HJ, Baek HJ. Infliximab for refractory oral ulcers. Am J Otolaryngol. 2014;35(5):664–8.

    Article  PubMed  Google Scholar 

  5. Liu D, Zhang T, Zhou H, Meng Y, Wu C, Sun Y, Xu Y, Deng X, Wang H, Jiang L. Role of biologics in refractory recurrent aphthous stomatitis. J Oral Pathol Med. 2022;51(8):694–701.

    Article  PubMed  Google Scholar 

  6. Bender A, Fix C, Eubel V, Eming R, Pollmann R, Schmidt T, Hertl M. Adjuvant high-dose intravenous immunoglobulins for recalcitrant erosive oral lichen planus: mixed clinical responses. Eur J Dermatol : EJD. 2018;28(4):496–501.

    Article  PubMed  Google Scholar 

  7. Meng W, Zhou Y, Zhang H, Jiang L, Wang Z, Li X, Zhou H, Chen Q, Zeng X. Nasal-type NK/T-cell lymphoma with palatal ulcer as the earliest clinical manifestation: a case report with literature review. Pathol Oncol Res. 2010;16(1):133–7.

    Article  PubMed  Google Scholar 

  8. Zhang X, Wang J, Wang F, Jin X, Zhou Y, Dan H, Zeng X. Extensive erosion instead of leukoplakia can be the oral manifestation of dyskeratosis congenita. Oral Dis. 2019;25(3):919–21.

    Article  PubMed  Google Scholar 

  9. Solimani F, Maglie R, Pollmann R, Schmidt T, Schmidt A, Ishii N, Tackenberg B, Kirschbaum A, Didona D, Pickert J, et al. Thymoma-Associated Paraneoplastic Autoimmune Multiorgan Syndrome-From Pemphigus to Lichenoid Dermatitis. Front Immunol. 2019;10:1413.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Teoh L, Moses G, McCullough MJ. A review and guide to drug-associated oral adverse effects-Oral mucosal and lichenoid reactions. Part 2. J Oral Pathol Med. 2019;48(7):637–46.

    Article  PubMed  Google Scholar 

  11. Kneisel A, Hertl M. Autoimmune bullous skin diseases Part 1: Clinical manifestations. J Dtsch Dermatol Ges: JDDG. 2011;9(10):844–56; quiz 857.

    PubMed  Google Scholar 

  12. Kim JH, Kim SC. Paraneoplastic Pemphigus: Paraneoplastic Autoimmune Disease of the Skin and Mucosa. Front Immunol. 2019;10:1259.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A. Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management. J Formos Med Assoc. 2018;117(9):756–65.

    Article  PubMed  Google Scholar 

  14. Fitzpatrick SG, Cohen DM, Clark AN. Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review. Head Neck Pathol. 2019;13(1):91–102.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Egami S, Yamagami J, Amagai M. Autoimmune bullous skin diseases, pemphigus and pemphigoid. J Allergy Clin Immunol. 2020;145(4):1031–47.

    Article  PubMed  Google Scholar 

  16. Montagnon CM, Lehman JS, Murrell DF, Camilleri MJ, Tolkachjov SN. Subepithelial autoimmune bullous dermatoses disease activity assessment and therapy. J Am Acad Dermatol. 2021;85(1):18–27.

    Article  PubMed  Google Scholar 

  17. Schmidt E, Kasperkiewicz M, Joly P. Pemphigus. Lancet (London, England). 2019;394(10201):882–94.

    Article  Google Scholar 

  18. Frew JW, Murrell DF. Paraneoplastic pemphigus (paraneoplastic autoimmune multiorgan syndrome): clinical presentations and pathogenesis. Dermatol Clin. 2011;29(3):419–25.

    Article  PubMed  Google Scholar 

  19. Nishijima T, Kawana K, Fukasawa I, Ishikawa N, Taylor MM, Mikamo H, Kato K, Kitawaki J, Fujii T. Effectiveness and Tolerability of Oral Amoxicillin in Pregnant Women with Active Syphilis, Japan, 2010–2018. Emerg Infect Dis. 2020;26(6):1192–200.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Thakrar P, Aclimandos W, Goldmeier D, Setterfield JF. Oral ulcers as a presentation of secondary syphilis. Clin Exp Dermatol. 2018;43(8):868–75.

    Article  PubMed  Google Scholar 

  21. Patton L. Progress in understanding oral health and HIV/AIDS. Oral Dis. 2014;20(3):223–5.

    Article  PubMed  Google Scholar 

  22. Kakisi OK, Kechagia AS, Kakisis IK, Rafailidis PI, Falagas ME. Tuberculosis of the oral cavity: a systematic review. Eur J Oral Sci. 2010;118(2):103–9.

    Article  PubMed  Google Scholar 

  23. Alrashdan MS, Cirillo N, McCullough M. Oral lichen planus: a literature review and update. Arch Dermatol Res. 2016;308(8):539–51.

    Article  PubMed  Google Scholar 

  24. Olson MA, Rogers RS 3rd, Bruce AJ. Oral lichen planus. Clin Dermatol. 2016;34(4):495–504.

    Article  PubMed  Google Scholar 

  25. Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, et al. Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer. Oral Dis. 2021;27(8):1862–80.

    Article  PubMed  Google Scholar 

  26. Herzum A, Gasparini G, Cozzani E, Burlando M, Parodi A. Atypical and Rare Forms of Cutaneous Lupus Erythematosus: The Importance of the Diagnosis for the Best Management of Patients. Dermatology (Basel, Switzerland). 2022;238(2):195–204.

    Article  Google Scholar 

  27. Philpot HC, Elewski BE, Banwell JG, Gramlich T. Pyostomatitis vegetans and primary sclerosing cholangitis: markers of inflammatory bowel disease. Gastroenterology. 1992;103(2):668–74.

    Article  PubMed  Google Scholar 

  28. Bardasi G, Romagnoli A, Foschini MP, Mantovani A, Alvisi P. Pyostomatitis vegetans in a pediatric patient with ulcerative colitis: case report of a rare pediatric inflammatory bowel disease extraintestinal manifestation and review of the literature. Eur J Gastroenterol Hepatol. 2020;32(7):889–92.

    Article  PubMed  Google Scholar 

  29. Monsereenusorn C, Rodriguez-Galindo C. Clinical Characteristics and Treatment of Langerhans Cell Histiocytosis. Hematol Oncol Clin North Am. 2015;29(5):853–73.

    Article  PubMed  Google Scholar 

  30. Rizzoli A, Giancristoforo S, Haass C, De Vito R, Gaspari S, Scapillati E, Diociaiuti A, El Hachem M. Congenital self-healing reticulohistiocytosis in a newborn: unusual oral and cutaneous manifestations. Ital J Pediatr. 2021;47(1):135.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J. Follicular lymphoma. Nature Rev Dis Primers. 2019;5(1):83.

    Article  Google Scholar 

  32. Wagner VP, Rodrigues-Fernandes CI, Carvalho MVR, Dos Santos JN, Barra MB, Hunter KD, Aguirre-Urizar JM, van Heerden WFP, Vargas PA, Fonseca FP, et al. Mantle cell lymphoma, malt lymphoma, small lymphocytic lymphoma, and follicular lymphoma of the oral cavity: An update. J Oral Pathol Med. 2021;50(6):622–30.

    Article  PubMed  Google Scholar 

  33. Messadi DV. Diagnostic aids for detection of oral precancerous conditions. Int J Oral Sci. 2013;5(2):59–65.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Muhvić-Urek M, Tomac-Stojmenović M, Mijandrušić-Sinčić B. Oral pathology in inflammatory bowel disease. World J Gastroenterol. 2016;22(25):5655–67.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Paolino G, Didona D, Magliulo G, Iannella G, Didona B, Mercuri SR, Moliterni E, Donati M, Ciofalo A, Granata G, et al. Paraneoplastic Pemphigus: Insight into the Autoimmune Pathogenesis, Clinical Features and Therapy. Int J Mol Sci. 2017;18(12):2532.

    Article  PubMed Central  Google Scholar 

  36. Kridin K. Pemphigus group: overview, epidemiology, mortality, and comorbidities. Immunol Res. 2018;66(2):255–70.

    Article  PubMed  Google Scholar 

  37. Tuddenham S, Hamill MM, Ghanem KG. Diagnosis and Treatment of Sexually Transmitted Infections: A Review. JAMA. 2022;327(2):161–72.

    Article  PubMed  Google Scholar 

  38. Ruocco V, Ruocco E, Caccavale S, Gambardella A, Lo SA. Pemphigus vegetans of the folds (intertriginous areas). Clin Dermatol. 2015;33(4):471–6.

    Article  PubMed  Google Scholar 

  39. de Andrade BAB, Fontes MD, Roza A, Vargas PA, Agostini M, Canedo NHS, Ramos DD, Morais JC, Milito CB, Romañach MJ. Anaplastic Large Cell Lymphoma with Oral Manifestation: A Series of Four Cases and Literature Review. Head Neck Pathol. 2020;14(4):991–1000.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Saleh A, Kong YH, Vengu N, Badrudeen H, Zain RB, Cheong SC. Dentists’ perception of the role they play in early detection of oral cancer. Asian Pac J Cancer Prev. 2014;15(1):229–37.

    Article  PubMed  Google Scholar 

  41. Kitayama A, Misago N, Okawa T, Iwakiri R, Narisawa Y. Pyodermatitis-pyostomatitis vegetans after subtotal colectomy for ulcerative colitis. J Dermatol. 2010;37(8):714–7.

    Article  PubMed  Google Scholar 

  42. Vega F, Lin P, Medeiros LJ. Extranodal lymphomas of the head and neck. Ann Diagn Pathol. 2005;9(6):340–50.

    Article  PubMed  Google Scholar 

  43. Silva TD, Ferreira CB, Leite GB, de Menezes Pontes JR, Antunes HS. Oral manifestations of lymphoma: a systematic review. Ecancermedicalscience. 2016;10:665.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Barone S, Buffone C, Ferrillo M, Pasqua F, Parrotta S, Salviati M, Bennardo F, Antonelli A. Oral Malignant Non-Hodgkin Lymphoma: A Retrospective Single-Center Study. Int J Environ Res Public Health. 2022;19(5):2605.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Coskunses FM, Cilasun Ü, Celik Topcu P, Tokuc B. Primary diffuse large B-cell lymphoma of the mandible: A case report. Gerodontology. 2020;37(3):307–11.

    Article  PubMed  Google Scholar 

  46. Booken N, Heck M, Peitsch WK, Goerdt S, Klemke CD. Ulcerated nodules on the oral mucosa and fingers: lymphomatoid papulosis, type A. Acta Derm Venereol. 2013;93(2):250–1.

    Article  PubMed  Google Scholar 

  47. Batta N, Shukla M, Pandey M. Natural course of diffuse large B cell lymphoma-a manifestation in buccal mucosa. World J Surg Oncol. 2019;17(1):219.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Kämmerer PW, Schiegnitz E, Hansen T, Draenert GF, Kuffner HD, Klein MO. Multiple primary enoral soft tissue manifestations of a Hodgkin lymphoma–case report and literature review. Oral Maxillofac Surg. 2013;17(1):53–7.

    Article  PubMed  Google Scholar 

  49. Niscola P, Palombi M, Fratoni S, Trawinska MM, Scaramucci L, Ales M, Tendas A, Cupelli L, Perrotti A, de Fabritiis P. Primary MALT lymphoma of the upper lip mucosa: an exceptionally rare localisation. Int J Hematol. 2009;89(1):130–1.

    Article  PubMed  Google Scholar 

  50. Wain EM, Setterfield J, Judge MR, Harper JI, Pemberton MN, Russell-Jones R. Mycosis fungoides involving the oral mucosa in a child. Clin Exp Dermatol. 2003;28(5):499–501.

    Article  PubMed  Google Scholar 

  51. Hata T, Aikoh T, Hirokawa M, Hosoda M. Mycosis fungoides with involvement of the oral mucosa. Int J Oral Maxillofac Surg. 1998;27(2):127–8.

    Article  PubMed  Google Scholar 

  52. Vicente A, Martí RM, Martín E, Estrach T, Herrero C, Mascaró JM. Mycosis fungoides with oral involvement. Int J Dermatol. 1991;30(12):864–6.

    Article  PubMed  Google Scholar 

  53. Chuong R, Martof AB, Fechner RE. Oral mucosal presentation of lymphoma: report of case. J Am Dent Assoc (1939). 1984;108(2):196–9.

    Article  Google Scholar 

  54. Yokobayashi Y, Nakajima T, Fikushima M, Ishiki T. Non-Hodgkin’s lymphoma of the gingiva. A case report. Int J Oral Surg. 1981;10(5):359–62.

    Article  PubMed  Google Scholar 

  55. Campeanu AT, Dumea E, Rus M, Fodor C, Ionescu AC, Mocanu E, Botnarciuc M, Dumitru IM. A Rare Case of Plasmablastic Lymphoma in a Patient with HIV and SARS-CoV-2 Infections. Current oncology (Toronto, Ont). 2022;29(3):1537–43.

    Article  Google Scholar 

  56. Lyu X, Guan X. Gingival Ulceration. N Engl J Med. 2021;385(11): e33.

    Article  PubMed  Google Scholar 

  57. Hafian H, Schvartz H, Patey M, Quinquenel A. Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report. BMC Oral Health. 2021;21(1):597.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Yu W, Park C, Shimel B. Oral manifestations and clinical progression of a rare double-hit B-cell lymphoma: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;130(2):e38–43.

    Article  PubMed  Google Scholar 

  59. Kamat M, Datar U, Kanitkar S, Byakodi S. Intraoral HIV-associated Burkitt’s lymphoma: a rare case report with special emphasis on differential diagnosis. J Korean Assoc Oral Maxillofac Surg. 2019;45(4):225–9.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Marcucci M, Marcucci G, Cordeiro MS, León JE, Araujo JP, de Oliveira JX, Santos KCP. Mantle cell lymphoma: involvement of nodal and extranodal sites in the head and neck, with multifocal oral lesions. Autops Case Rep. 2017;7(3):26–31.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Frei M, Dubach P, Reichart PA, Schmitt AM, Mueller-Garamvölgyi E, Bornstein MM. Diffuse swelling of the buccal mucosa and palate as first and only manifestation of an extranodal non-Hodgkin “double-hit” lymphoma: report of a case. Oral Maxillofac Surg. 2012;16(1):69–74.

    Article  PubMed  Google Scholar 

  62. Zanakis SN, Kambas I, Gourlas PG. A non-Hodgkin’s lymphoma in the buccal mucosa. A case report. Oral Surg Oral Med Oral Pathol. 1992;74(3):340–2.

    Article  PubMed  Google Scholar 

  63. Mignogna MD, Fortuna G, Falleti J, Leuci S. Gastric diffuse large B-cell lymphoma (DLBCL) exhibiting oral acanthosis nigricans and tripe palms. Dig Liver Dis. 2009;41(10):766–8.

    Article  PubMed  Google Scholar 

  64. Patil K, Mahima VG, Srikanth HS. Extranodal non-Hodgkin’s lymphoma of the gingiva in an HIV seropositive patient. Indian J Sex Transm Dis AIDS. 2010;31(2):112–5.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan WC, Fisher RI, Braziel RM, Rimsza LM, Grogan TM, et al. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med. 2004;351(21):2159–69.

    Article  PubMed  Google Scholar 

  66. Vyth-Dreese FA, Boot H, Dellemijn TA, Majoor DM, Oomen LC, Laman JD, Van Meurs M, De Weger RA, De Jong D. Localization in situ of costimulatory molecules and cytokines in B-cell non-Hodgkin’s lymphoma. Immunology. 1998;94(4):580–6.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We would like to thank the pathological assistance from all staffs at the Department of Oral Pathology in West China Hospital of Stomatology from Sichuan University.

Funding

This work is supported by National Natural Science Foundation of China (81902782, 82002888, 81730030), Research Funding from West China School/Hospital of Stomatology Sichuan University(No.RCDWJS2022-16), the CAMS Innovation Fund for Medical Sciences(CIFMS, 2019-I2M-5–004), the 14th special grant from China Postdoctoral Science Foundation (2021T140484) and the 69th general grant from China Postdoctoral Science Foundation (2021M692267). All of these funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

Author information

Authors and Affiliations

Authors

Contributions

YW was mainly responsible for drafting and organization of the work, YZ collated the literature data and participated in the draft preparation, CL conducted the literature search and took part in the revision of main text, YX organized the revised Fig. 4 and assisted in the revision of the main text, SJ was responsible for collecting the pathological information of patient and participated in the revision of new tables, YJ and YQ assisted in the revision of the work, XL made contributions to the conceptional design and substantively revised the work, QC provided suggestions to the conceptional design of the work and revised the work. All authors have approved the final manuscript.

Corresponding authors

Correspondence to Xiaobo Luo or Qianming Chen.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Written informed consent was obtained from the patient for publication of this case study. A copy of the written consent is available for review by the editor of this journal.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wu, Y., Zhang, Y., Li, C. et al. Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review. BMC Oral Health 22, 514 (2022). https://doi.org/10.1186/s12903-022-02567-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12903-022-02567-7

Keywords

  • Follicular lymphoma
  • Erosive and proliferative lesions
  • Oral manifestation
  • Case report